Use of mediation analysis to evaluate the role of adherence on the comparative effects of atypical antipsychotics in schizophrenia

John Michael Fastenau, Thomas Jefferson University

Abstract

Schizophrenia is a serious mental illness requiring lifelong treatment and antipsychotics are used to alleviate debilitating symptoms. Increasingly, payers are implementing formulary controls affecting access to these essential medications, though other barriers to use exist. While the comparative effects of antipsychotics have been assessed, findings from recently published meta-analyses and other study methodologies are inconsistent. Some suggested a benefit, others not, for long-acting injectable (LAI) over oral antipsychotics. The primary objective of this research was to measure the indirect effects of LAI and oral atypical antipsychotics on hospital re-admission, mediated through an adherence causal pathway. Mediation is an analytical approach to understand causal pathways and address important research questions regarding how interventions may transmit effects on outcomes. The use of mediation analysis for comparative effectiveness research (CER) is underutilized. (Abstract shortened by ProQuest.)

Subject Area

Mental health|Health sciences|Public health

Recommended Citation

Fastenau, John Michael, "Use of mediation analysis to evaluate the role of adherence on the comparative effects of atypical antipsychotics in schizophrenia" (2016). ETD Collection for Thomas Jefferson University. AAI10062295.
https://jdc.jefferson.edu/dissertations/AAI10062295

Share

COinS