ProQuest ETD Collection - Thomas Jefferson University
This collection contains Thomas Jefferson University theses and dissertations from an automatic ProQuest feed. Records in this collection contain an abstract of the thesis/dissertation and a link out to ProQuest. Note: Full-text access to theses/dissertations via ProQuest is available for the Jefferson community.
Dissertations & Theses from 2025
Baqai, Usman (2025) Identifying the Novel Effectors of Oncogenic GNAQ/11 and BAP1-Deficiency in Uveal Melanoma
Dissertations & Theses from 2024
Barton, Joshua R (2024) Regulation of the Gut-Brain Axis by Guanylyl Cyclase C
Benavides, Nathalia (2024) Investigating Mechanisms of T Cell Activation Through Lipid Modulation and Pediatric Immune Dysregulation Disorders
Gandhi, Hema (2024) An Exploration and Confirmation of the Measurement of Healthcare Experiences of Children With Autism: Analysis of the 2019 and 2020 National Survey of Children’s Health
Geonnotti, Gabrielle (2024) Evaluating the Impact of Obstetrical Unit Closures on Severe Maternal Morbidity in Pennsylvania
Hill, Brianna Leigh (2024) Dsg2-Regulated miRNA and lncRNA Dynamics in Wound Healing and Tumor Development
Karliner, Jordyn (2024) Investigating the Molecular Mechanisms of Neurite Loss in Spinal and Bulbar Muscular Atrophy
Lisberg, Allison (2024) Identifying the Mechanism Behind the Role of the AR N/C Interaction in SBMA
McGettigan, Shannon Eileen (2024) The Homeostasis of IgM Secreting Cells in Skin and Lymphoid Tissues and the Role of Secreted IgM in Modulating Il-10+ B Cells
Vukovic, Ivana (2024) Non-Redundant Roles for the Human mRNA Decapping Cofactor Paralogs DCP1a and DCP1b
Dissertations & Theses from 2023
Aimino, Michael A (2023) Synaptic Development in Different Olfactory Neuron Classes Uses Distinct Temporal and Activity-Related Programs
Babalola, Olufemi (2023) Quantifying Patient Preferences for Treatments for Refractory Chronic Spontaneous Urticaria
Basta, Morgan D (2023) The Role of Post-Replicative Chromatin Structure in the Initiation and Progression of Fibrosis
Borgen, Irene (2023) Patient and Provider Satisfaction and Provider Intent to Use Virtual Video Technology for Medical and Surgical Visits in an Urban Ambulatory Setting During and in Peri-COVID-19 Era
Byrne, Matthew Daniel (2023) Interactions Between Genetics, Protein, and Inflammation in Modeling Synucleinopathies
Chen, Carolyn Ge (2023) Autophagic Degradation of Hyaluronan Synthase 2: A Novel Mechanism to Regulate Angiogenesis in Breast Cancer
Crittendon, Denine R (2023) Identification of Conceptual Domains Associated with Normalized Structural Racism in Healthcare Delivery that Contribute to Quality of Care Disparities Between Patients Racialized as Non-Hispanic Black/African American and Non-Hispanic White
DePew, Alison T (2023) Presynaptic LRP4 Directs Synapse Development and Cytoskeletal Organization at the Drosophila Neuromuscular Junction
DiCarlo, Melissa A (2023) Identifying and Mapping Barriers and Facilitators to Urban Trail Use: A Qualitative Geographic Information Systems Study
Flickinger, John C. (2023) Guanylyl Cyclase C Vaccines for Secondary Prevention of Metastatic Colorectal Cancer
Freeland, Catherine (2023) Strategies for Improving Hepatitis B Birth Dose in Nigeria
Haines, Adam (2023) Chlamydia trachomatis Coordinates Distinct Cytoskeletal Elements to Regulate Its Virulence
Hwang, Daniel (2023) CSF-1 Maintains Pathogenic but Not Homeostatic Myeloid Cells in the Central Nervous System During Autoimmune Neuroinflammation
Isguven, Selin (2023) Ultrasound-Controlled Drug Delivery for Application in Spinal Surgical Infections
Johnston, Shira N (2023) The Role of HIF-2α in the Intervertebral Disc
Kanzinger, Carrie (2023) Emergency Room Frequent Users: Leveraging Healthcare Behavioral and Predictive Analytic Frameworks to Create Operationally Effective Predictive Models in a Care Management Setting
Laspata, Natalie (2023) Investigating the Role of Poly (ADP-Ribose) Polymerase 1 (PARP1) in the Prevention of R-Loop-Mediated Genomic Instability
Montoya, Brian (2023) Studies on the Role of Necroptosis Proteins RIPK3 and MLKL in Resistance to Viral Infection and on the Role of CD8 T-Cells Induced by mRNA-LNP Vaccines in Protection from SARS-CoV-2 in Mice
Nelson, Andrew Tyler (2023) Determining the Role of Glucose Hypometabolism as a Modifier of C9orf72-ALS/FTD: Potential Mechanisms and Downstream Consequences
Rappaport, Jeffrey (2023) APC-β-Catenin-TCF Signaling Silences the GUCY2C Tumor Suppressor Axis in Colorectal Cancer
Rimal, Abhimannyu (2023) ISC10, a Developmentally Regulated Inhibitor of Non-Canonical MAPK Signaling
Scher, Gabrielle (2023) Development of Rhabdoviral-Based Crimean-Congo Hemorrhagic Fever Virus Vaccines
Yankowski, Catherine (2023) Formulation of the Rabies Virus Vaccine Vector Against Emerging Viruses
Young, Michael Philip (2023) IP3R Knockout Cell Models: Studies on Structure/Function and Cell Physiology
Dissertations & Theses from 2022
Barnhart, Benjamin (2022) Partial Hepatectomy as a Model of Liver Regeneration: Network-Based Profiles
Blanchard, Jeremy J (2022) Modeling Medicare for All in the United States
Brecher, Alison C (2022) Patient Perceptions of Medical Stigma Related to Smoking: Development of a Patient-Reported Experience Measure
Cao, Qingqing (2022) The Role of Type VII Collagen in Mediating Extracellular Matrix Protein Secretion in Recessive Dystrophic Epidermolysis Bullosa
Cherlin, Tess Amber (2022) Identifying, Characterizing, and Exploring the Profiles of Ribosomal RNA Fragments (rRFs) and Their Implications for Personalized Medicine Contexts
Cosma, Gabriela Ligia (2022) Protein Trafficking and Unchaperoned Translation During a Viral Infection Determine Antigen Processing Outcomes for MHC Class I Direct Presentation
Doll, Steven Gardner (2022) Recognition of the TDP-43 Nuclear Localization Signal by Importin α1/β
Domingo Vidal, Marina (2022) Metabolic Compartmentalization as a Driver of Head and Neck Squamous Cell Carcinoma Aggressiveness
Kavin, Michelle (2022) Assessment of Functional Disability in Osteoarthritis Patients with and without Diabetes Mellitus
Langbein, Lauren E (2022) Regulation of the Type I Interferon Pathway by Cancer Genes in Clear Cell Renal Cell Carcinoma
Lapadula, Dominic J (2022) Direct Inhibition of Oncogenic Gq/11 in Uveal Melanoma
Molotsky, Elana (2022) The Impact of Androgen Receptor Polyglutamine Expansion on the Motor Unit in SBMA: NMJ Pathology, Motor Unit Vulnerability, and Neurofilament Dysregulation
Randolph, Clinita (2022) The Influence of Membrane Localization on Constitutively Active Gαq Signaling
Renna, Stephanie A (2022) Protease-Activated Receptor 4 and Its Contribution to Immune Thrombotic Thrombocytopenia Disorders
Roche, Megan Elizabeth (2022) Translocase of the Outer Mitochondrial Membrane 20 (TOMM20) and TP53 Inducible Glycolysis and Apoptosis Regulator (TIGAR)) Drive Metabolic Reprogramming in Cancer
Saeidian, Amir Hossein (2022) Investigating the Molecular Genetics and Viral Repertoire of Patients with Epidermodysplasia verruciformis
Schapiro, Hannah M (2022) Dissecting How Interactions at the Apex of HIV-1 Env Modulate Epitope Exposure at the Distant Base of the Glycoprotein
Shaik, Noor F (2022) The Role of Platelets in Remote Organ Injury and Infection After Stroke
Varney, Matthew J (2022) G Protein-Coupled Receptor Kinase 6 (GRK6) Regulation of Insulin Processing and Secretion
Zhao, Neil (2022) Reducing Staphylococcus Aureus Burden in Synovial Fluid
Dissertations & Theses from 2021
Agostini, Lebaron C (2021) Targeting Poly (ADP) Ribose Glycohydrolase as a Combinatorial Strategy to Enhance DNA Damage in Gastrointestinal Cancers
Brown, Eric V (2021) Differential Activation of Pain Circuitry Neuron Populations in Spinal Cord Injury Induced Neuropathic Pain
Brown, Samantha Zimmer (2021) Beyond Transcription: Studying Human Antigen R (HuR/ELAVL1) and Its Role in Post-Transcriptionally Regulating the Pancreatic Cancer-Driver, Yes-Associated Protein 1 (YAP1)
Charsar, Brittany Ann (2021) Respiratory Axon Plasticity Drives Recovery of Diaphragm Function After Spinal Cord Injury
Diecidue, Robert J (2021) Comparing Treatment Effectiveness and Patient-Reported Outcomes of Four Treatment Alternatives for Obstructive Sleep Apnea
Dylgjeri, Emanuela (2021) DNA-PKcs: Novel Roles and Therapeutic Targeting in Prostate Cancer
Farkas, Marina (2021) Elucidating Mechanisms Mediating Genome Recognition and Cell Fate Determination by p53
Fleming, Sarah (2021) Fibroblast Growth Factor Receptor Status and Advanced Bladder Cancer Progression: a Retrospective Study
Florio, Tyler J (2021) Mechanisms and Regulation of Nf-κB Nuclear Import Through Importin α Isoforms
Gorth, Deborah J (2021) The Role of TNFα and IL-1β in Intervertebral Disc Disease and Health
Haber, Alex Owen (2021) Pre-Clinical Investigations of the Second-Generation Polymeric Fluoropyrimidine, ARAC-FdUMP[10] (CF10), for the Treatment of Gastrointestinal Cancers
Heinsinger, Nicolette M (2021) Modulating EphBs in the Dorsal Horn Attenuates Neuropathic Pain After Cervical Spinal Cord Injury
Heng, Vibol (2021) Neurobiological and Behavioral Characterization of Adult Male and Female Mice in Prolonged Social Isolation
Hodge, Rachel (2021) Human Sex-Specific Synaptic Adhesion Proteins NLGN4X and NLGN4Y Regulate the Dual Innervation of Dendritic Spines
Ippolito, Michael (2021) Selective Activation of G Protein Signaling through the β2ar via Novel and Redefined Small Molecule Ligands
Kolb, Alexus D (2021) Osteoclastogenesis and Factors Produced by the Bone Extracellular Matrix Are Altered by Educated Osteoblasts in a Bone-Tumor Mimetic Microenvironment
Mandigo, Amy Catherine (2021) E2F1 and Androgen Receptor Dysregulation Drives RB-Deficient Cancer Progression
Mayes-Hopfinger, Lindsey Gail (2021) Identifying WNK1 as a Negative Regulator of NLRP3 Inflammasome Activation and Pyroptosis
McCurdy, Rebekah Jo (2021) Implementation of a Screening Guideline for and Multidsciplinary Clinic Care of Pregnant Women with Underlying Cardiac Disease in an Urban Academic Healthcare System
Moss, Alison Rachel (2021) Central and Peripheral Transcriptomic Networks Driving Cardiovascular Control
Nguyen, Mai (2021) Optimizing MEK Inhibitors in NRAS Mutant Melanoma - Overcoming Resistance and Combination Strategies
O'Sullivan, Sean (2021) The Effect of Alcohol and Opioid Withdrawal on Single-Cell Glia and Neuronal Gene Expression in the Visceral Emotional Neuraxis
Parrish, Austin (2021) Systems-Level Analysis of Regulatory Networks Involved in Alcoholic Liver Disease
Rosenbaum, Sheera (2021) The Role of Lineage-specific Transcription Factors in Regulating Anti-tumor Immune Responses in Melanoma
Sarfallah, Azadeh (2021) Mechanism of Transcription Initiation and Primer Generation at the Mitochondrial Origin of Replication, OriL
Sulon, Sarah M (2021) Regulation of G Protein-Coupled Receptor Kinase 5 by Calmodulin
Swanson, Nicholas A (2021) The Architecture of a Prototypical Bacterial Virus DNA-Ejectosome
Verdone, Brandie Morris (2021) Understanding the Consequences of Dipeptide Repeat Protein Formation in C9orf72-Als/Ftd
Washburn, Halley Rebecca (2021) Molecular Mechanisms of the EphB-NMD Receptor Extracellular Interaction
Dissertations & Theses from 2020
Fisher, Christine Rettew (2020) Development and Characterization of a Broadly Protective Lyssavirus Vaccine
Javed, Elham (2020) Intermediate Filaments in Bladder Smooth Muscle Dysfunction
Kurup, Drishya (2020) Development of a Zika Virus Vaccine
Merkel, Lori Damiano (2020) An Implementation Science Perspective on the Effectiveness of Primary Care Teams
Muqeem, Tanziyah (2020) The Role of Kv3.4 Channels in the Neurotransmission of Pain
Patel, Pravin (2020) Role of ASK1 in Platelet Activation and Immune-Induced Thrombocytopenia and Thrombosis
Pattison, Amanda (2020) Reactivating the GUCY2C Signaling Axis for Colorectal Cancer Chemoprevention
Rasouli, Javad (2020) ThG Cells: A Distinct T Helper Cell Subset with Lineage Characteristics
Satchell, Marlon D (2020) Using the Medical Expenditure Panel Survey to Explore the Association between High Healthcare Utilization and Behavioral Health Diagnoses in a Pediatric Population with Chronic Disease
Stotesbury, Colby (2020) Defects of the Innate Immune System Contribute to Age-related Susceptibility to Mousepox
Vido, Michael J (2020) Mechanisms Underlying RAF Inhibitor Resistance by BRAF Splice Variants in Melanoma
Yang, Elaine (2020) Mechanisms of Voltage-Gated Na+ Channel Inhibition by Propofol
Youssefian, Leila (2020) Investigating the Molecular Genetics of Patients with Ichthyoses/Mendelian Disorders of Cornification (MeDOC)
Dissertations & Theses from 2019
Arnold, Frederick Jay (2019) Altered Trafficking and Post-translational Modifications of the Polyglutamine-Expanded Androgen Receptor Contribute to Toxicity in Spinal and Bulbar Muscular Atrophy
Bisetto, Sara (2019) New Insights into the Lactate Shuttle: Lesson Learned from the MCT4 Knock Out Mouse
Choi, Hyowon (2019) The Role of Autophagy and Primary Cilia in the Nucleus Pulposus
Davis, Benjamin M (2019) Ifit2 in the Innate Immune Response to Rabies Virus
DeRita, Rachel Marianna (2019) The Signaling Axis of β1 integrins in Prostate Cancer Extracellular Vesicle Biology
Gennaro, Victoria J (2019) Defining the MYC Transcriptional Regulatory Network in Human Cancer
Gubbiotti, Maria Alexandria (2019) A Novel Role for Decorin in Autophagy and Metabolism
Hurst, Stephen J (2019) Calcium Regulation of the Mitochondrial Permeability Transition Pore during Ischemia Reperfusion Injury of the Heart
Keshwara, Rohan B (2019) Development of a Rabies-Vectored Marburg Virus Vaccine and Elucidation of a Potential Mechanism of Protection
Logan, Caitlin M (2019) Impact of the Loss of N-Cadherin or Microtubules on Lens Development and Immune Surveillance
Marin, Diego (2019) Biomarkers in Reproductive Medicine: Toward Selecting the Best IVF Embryo for Transfer
McAvoy, Kevin James (2019) Non-cell Autonomous Toxicity in Motor Neuron Disease: Evidence and Mechanisms of Astrocyte-Driven Neurotoxicity in FUS-ALS
McCann, Jennifer Jones (2019) Mechanisms and Impact of DNA Repair Dysfunction in Prostate Cancer
Rogers, Corey L (2019) Identifying GSDME/DFNA5 as a Multifaceted Regulator of the Apoptotic Program
Rosenblum, Lauren Taylor (2019) Alternative Pathway of EAAT2-Mediated Toxicity in Amyotrophic Lateral Sclerosis
Salem, Israa (2019) Cancer Cell-Monocyte Communication Mediated by Small Extracellular Vesicles
Sanchez, Ileine (2019) Novel Strategies for Combatting Acquired Resistance to Combined BRAF and MEK Inhibition in Mutant BRAF Melanomas
Schultz, Christopher William (2019) Targeting Therapeutically Relevant Vulnerabilities Induced by Pancreatic Ductal Adenocarcinoma Genetics and Microenvironment
Silagi, Elizabeth S (2019) Insights into Glycolytic Metabolism and pH Homeostasis in the Hypoxic Intervertebral Disc
Stanek, Timothy J (2019) Characterizing the Role of Epigenetic Regulator USP22 in Human Cancer
Swarup, Aditi (2019) Deletion of GLUT1 from Ocular Epithelium Leads to Cataract Formation and Photoreceptor Degeneration in Mice
Urban, Mark William (2019) Targeted Restoration of Respiratory Neural Circuitry following Cervical Spinal Cord Injury
Wilski, Nicole A (2019) Murine Cytomegalovirus Promotes Anti-tumor Immunity in a Melanoma Model by Recruiting Macrophages and Inducing Inflammation through STING Signaling
Dissertations & Theses from 2018
Abraham, Tara (2018) Targeting Mechanisms of GUCY2C-specific Tolerance for Cancer Immunotherapy
Atanasova, Velina S (2018) Novel Therapeutic Approaches for Recessive Dystrophic Epidermolysis Bullosa
De Dominici, Marco (2018) Transcriptional Targets Mediating the MYB Addiction of Ph+ Acute Lymphoblastic Leukemia
Doyle, Laura A (2018) Defining the Landscape of Radiation Oncology Accreditation in the United States
Garcia, Samantha A (2018) Long-term Protection against a Pathogenic Wild-Type RABV CNS Challenge and the Establishment of Tissue Resident Long-Lived Effector Cells during Immunization
German, Eileen M (2018) Effects of the Care Transition Intervention in the PCMH on Heart Failure 30 Day Readmissions
Gorky, Jonathan (2018) The Emergence of Cardioprotection from the Brain-Gut-Heart Network
Harrison, Amy S (2018) Performance Metrics in Radiation Oncology: Benchmarking Practice and Future Planning
Henderson, Nathan T (2018) Trans-synaptic Coordination of Synapse Development and Plasticity: A Focus on Ephrin-B3 and PSD-95
Ho Wei, Lan (2018) Uncovering the Landscape of Noncanonical Hedgehog Signaling
Kornuszko-Story, Margaret A (2018) Functional Status in Hospitalized Senior Patients: Measurement, Prediction Models, and Cost-Saving Opportunities
Kostuk, Eric Wildon (2018) Which Dopamine Neurons Live or Die in Parkinson's Disease: A Balancing Act Between Protective Astrocytes and Deleterious Microglia
Masire, Phatsimo (2018) Insurance Status and Hepatocellular Carcinoma Staging, Treatment and Survival: A SEER Database Analysis
Merlino, Dante J (2018) Two Distinct GUCY2C Neuronal Pathways in the Hypothalamus and Midbrain
Overmiller, Andrew (2018) Dsg2 Enhances Oncogenic Cellular Signaling in an Autocrine and Paracrine Manner
Payton, Colleen Anne (2018) An Examination of Large Employer Workplace Lactation Support: Organizational Support and Employee Perceptions
Telonis, Aristeidis G (2018) Computational and Systems Biology Studies of Human Trna Fragments and Micro RNA Isoforms and Their Involvement in Race Disparities in Triple-Negative Breast Cancer
Westergard, Thomas Raymond Stefeson (2018) Dipeptide Repeat Proteins Associated with C9orf72 ALS/FTD: Understanding How They Are Made and How They Potentiate Disease
Whitley, Michael (2018) The Effect of the PAR4 Ala120Thr Variant on the Platelet Thrombin Response, Receptor Desensitization, and Platelet Antagonists
Dissertations & Theses from 2017
Ahn, Koree Wee (2017) Dissecting the Complex Mechanisms Behind the Combinatorial Activities of HIV-1 Entry Inhibitors
Chand, Saswati (2017) HuR regulates Poly ADP Ribose Glycohydrolase: Implications for PARP inhibitor efficacy in pancreatic ductal adenocarcinoma cells
Eisemann, Travis (2017) Structural Analysis of Tankyrase-1 Regulation and Binding Partner Interaction
Gubernick, Ruth S (2017) Evaluating Family-Centered Care in Florida's Pediatric Medical Home Demonstration Project
Johnson, Zariel I (2017) Novel Roles of Transcription Factor TonEBP in Nucleus Pulposus Cells of the Intervertebral Disc
Khasnis, Mukta Dilip (2017) Dissecting Receptor-Induced Activation of HIV-1 Env
Lytle, Andrew G (2017) Infection and Activation of Immune Cells by Rabies Virus-Based Vaccines
McNair, Christopher M (2017) Androgen Receptor and Cell Cycle Interplay in Cancer: Mechanisms and Implications
Myers, Carey Jeanne (2017) Combining Thoracic Irradiation and An Anti-PD-1 Antibody Decreases Survival Through Increased T Cell Infiltration into Cardiac and Lung Tissue
Noronha Antony, Anil (2017) The contribution of dynamic regulation of mitochondrial calcium uptake to liver pathophysiology
Oran, Amanda R (2017) Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer
Quinn, Michael (2017) Memory CD8+ T Cells Remain Functional throughout an Ongoing Persistent Infection: Implications for Antigen-Specific Immune Reconstitution and Boosting
Singh, Amrita (2017) Exosome-Mediated Transfer of Integrins Promotes Cell-Cell Communication in Prostate Cancer
Tandon, Mayank (2017) The Immune-Epithelial Interaction in the Pathogenesis of Primary Sjögren's Syndrome
Vu, Ha Linh (2017) Mutant NRAS and RAC1 signaling in melanoma
You, Jason C (2017) Epigenetic Regulation of Hippocampal Function and Cognition in Alzheimer's Disease
Zemel, Benjamin M (2017) Novel Modulation of a Dorsal Root Ganglion Potassium Channel by Calcineurin and Protein Kinase C
Dissertations & Theses from 2016
Anderson, Warren D (2016) Multi-scale analyses of molecular network dynamics underlying neuronal excitability, neuroinflammation, and organismal homeostasis
Berger, Tamar R (2016) Structural and Functional Features of the Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy
Blomain, Erik S (2016) Silencing of GUCY2C through loss of guanylin expression is a necessary step in colorectal tumorigenesis and therapeutic target for chemoprevention
Bongiorno, Emily K (2016) Therapeutic modulation of the tumor-promoting immune type 2 microenvironment in malignant glioma by the induction of a type 1 response to attenuated rabies virus
Chen, Dongying (2016) Roles of Fibronectin and Integrin α5 in Pharyngeal Arch Artery Morphogenesis
Cunningham, Amy Taylor (2016) Evaluation of the Jefferson Family Medicine Associates' Diabetes Information and Support for Your Health (DISH) Program
DeCicco, Danielle (2016) Dynamic microRNA networks in the brainstem underlie the development of hypertension
Dowling, John P (2016) Necroptotic and apoptotic signaling during development and immune homeostasis
Erkes, Dan A (2016) Exploiting Murine Cytomegalovirus as an Anti-Tumor Therapy and Model for Virus-Specific Tumor Infiltrating Lymphocytes
Fastenau, John Michael (2016) Use of mediation analysis to evaluate the role of adherence on the comparative effects of atypical antipsychotics in schizophrenia
Hoang, David Timothy (2016) Therapeutic Targeting of Stat5a/b in Advanced Prostate Cancer: Inhibition of Stat5a/b Suppresses Growth of Prostate Cancer through Mechanisms Dependent and Independent of Androgen Receptor
Hullmann, Jonathan E (2016) Protein-coupled receptor kinase 5 exacerbates cardiac pathology through activation of the nuclear factor of activated T cells pathway
Jin, Yuan-Yuan (2016) Developing microRNA therapeutics for triple negative breast cancer
Klayman, Lauren M (2016) Non-canonical G protein βγ signaling at the golgi
Ko, Ying-Hui (2016) Metabolic heterogeneity in breast cancer
Kraft, Crystal L (2016) Guanylyl cyclase C maintains integrity of intestinal stem cells through modulation of endoplasmic reticulum stress
Mogilyansky, Elena (2016) Post-transcriptional regulation of BRCA2 through interactions with miR-19a and mir-19b, two members of the miR-17/92 cluster
Monteith, Jessica A (2016) A rare DNA contact mutation in cancer confers p53 gain-of-function and alters binding specificity
Omerza, Gregory (2016) Regulation of Non-Canonical MAP Kinase Signaling
Quann, Kevin (2016) Cancer, Caveolin-1, and Non-Coding RNAs: Novel Insights into Tumor Biology
Rouleau, Lauren L (2016) The use of pharmacologic ascorbate in the treatment of hepatocellular carcinoma: mechanism of cytotoxicity and synergism with the multikinase inhibitor sorafenib
Schoepflin, Zachary (2016) Investigation of the HIF-PHD System in Nucleus Pulposus Cells of the Intervertebral Disc
Smith, Carmella Romeo (2016) HuR Contributes to the Therapeutic Resistance of Pancreatic Cancer
Tian, Xufan (2016) The functional roles of arrestin domain-containing protein 3 in regulating G protein-coupled receptor trafficking and signaling
Tio, Chong Wai (2016) Spatiotemporal Regulation of Non-Canonical MAPK Signaling
Torres, Annabel (2016) The Role of Paternally Expressed Gene 3 in Regulating Autophagy and Angiogenesis
Wen, Xinmei (2016) Identification of Pathogenic Determinants and Mechanisms of C9ORF72 linked ALS/FTD
Xiang, Bo (2016) Synergistic DNA + Adenovirus Prime-Boost Immunization in Metastatic Colorectal Cancer
Zhou, Honglei (2016) Systematic study of GPRC5A in the context of pancreatic ductal adenocarcinoma
Zhou, Yuhang (2016) MicroRNA-148a-3p and TULA-2 regulate platelet FcγRIIA signaling and heparininduced thrombocytopenia
Dissertations & Theses from 2015
Brennan-Crispi, Donna (2015) DSG2 synergizes with hedgehog signaling to promote skin tumor development
Carr, Richard (2015) Biasing G protein coupled receptor signaling using pepducins
Corbett, Brian F (2015) Network dysfunction and cognitive deficits in a mouse model of Alzheimer's disease
Eaton, Gregory J. (2015) Apoptosis Signal-Regulating Kinase 1 Modulates Endochondral Bone Formation and Osteoarthritis Progression
Fried, Nathan Thomas (2015) Adenosine and Migraine
Goodwin, Jonathan F (2015) Androgen receptor and DNA damage response crosstalk: Mechanisms and impact on cancer progression
Helms, Michelle Carll (2015) Mitotic-dependent phosphorylation of leukemia-associated rhogef (LARG) by Cdk1
Jimbo, Masaya (2015) Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells
Kim, Gilbert W (2015) Targeting GUCY2C for anti-obesity pharmacotherapy Uroguanylin Replacement Opposes Obesity by Restoring Anorexigenic GUCY2C Signaling Silenced by Overnutrition-Induced Uroguanylin Deficiency
Kugel, Curtis H. (2015) Adaptive and acquired responses of mutant braf melanomas to RAF/MEK inhibitors
Magee, Michael S (2015) Guanylyl Cyclase C-Targeted CAR-T Cell Therapy for the Treatment of Metastatic Colorectal Cancer
Pumroy, Ruth (2015) Regulation of the classical nuclear import pathway through variation in the structure and function of importin α isoforms
Riccio, Amanda A (2015) Poly(ADP-ribose) polymerase 2 (PARP-2) mechanism of DNA damage recognition and allosteric activation
Smith, Corinne J (2015) Hematogenous maintenance of memory inflation and continuous production of mucosal resident T cells during murine cytomegalovirus (MCMV) infection
Talati, Pooja G (2015) Mechanisms of prostate cancer metastasis induced by Stat5a/b signaling
Wesolowski, Jordan (2015) Bacteria use distinct mechanisms to inhibit SNARE-mediated membrane fusion
Wong, Eric B (2015) The role of SLAM family receptors in germinal center-mediated autoimmunity
Dissertations & Theses from 2014
Augello, Michael A (2014) Function of the Cyclin D1b oncogene in cancer progression: Mechanisms and implications
Barkhouse, Darryll (2014) Expression of interferon gamma by recombinant rabies virus strongly attenuates virus pathogenicity and enhances safety and efficacy of post-exposure treatment vectors
Black, Kathryn L (2014) Epigenetic Inheritance of Chromatin Structure during Replication and Mitosis
Correnti, Jason M (2014) Adiponectin in alcoholic liver disease and liver regeneration
Dastgheyb, Sana (2014) Staphylococcus aureus in the synovial environment: Supporting long-term survival and insensitivity to antibiotics
Goodenough, Elliot (2014) Proteomic insights into mhc class i antigen processing and presentation
Hollingsworth, Kristen (2014) The influence of the risk evaluation mitigation strategy on erythropoieses stiulating agent use in medicare patients with breast and lung cancers with chemotherapy induced anemia
Jablonski, Michael R (2014) Alterations in drug efflux at the blood-spinal cord barrier in amyotrophic lateral sclerosis
Kia, Azadeh Tehrani (2014) Characteristics of FUS-Mediated Toxicity in Amyotrophic Lateral Sclerosis
Neill, Thomas (2014) Decorin induces tumor cell mitophagy via mitostatin as the molecular basis for the suppression of angiogenesis
Retson, Tara A (2014) The interactions of alcohol, sex, and stress
Ronzone, Erik (2014) Insight into the mechanism of IncA, a type III secreted effector protein in Chlamydia trachomatis
Steblyanko, Maria A (2014) Role of integrin receptors in cytotoxic lymphocyte function
Zboray, Lori J (2014) Using cell and animal models to understand pathogenic mechanisms in spinal and bulbar muscular atrophy
Dissertations & Theses from 2013
Balasubramaniam, Sucharitha (2013) BAF57 Deregulation Orchestrates Novel Oncogenic Signaling and Prostate Cancer Progression
Barber, Annika F (2013) Modulation of voltage-gated potassium and sodium channels by halogenated general anesthetics: Structural and biophysical insights into the mechanisms of action
Basile, Kevin Joseph (2013) Examining mechanisms of RAF inhibitor resistance in mutant BRAF melanoma
Basu, Subhasree (2013) Signaling pathways crucial in differentiation initiation and terminal differentiation during lens development
Bonne-Annee, Sandra (2013) Strongyloides stercoralis - Immunological basis for susceptibility and resistance in mice and humans
Bryant, Kelly (2013) Exploring the Role of Caveolin1 Upregulation in the Prostate
Cullimore, Melissa (2013) Establishing a role for IL-27 in the amelioration of MS and EAE
Fineberg, Jeffrey D (2013) Elucidation of auto-regulatory mechanisms in voltage-gated potassium channels
Foran, Emily (2013) Implication of a sumoylated c-terminal fragment of the astroglial glutamate transporter, EAAT2 in the non-cell autonomous mechanisms of amyotrophic lateral sclerosis pathogenesis
Goodman, Chelain Rae (2013) Induction of a therapy-resistant cytokeratin 5-positive cell population by 3-ketosteroids in luminal breast cancer
Guarino, Nicole (2013) Studies of mitochondrial dysfunction in mutant SOD1-mediated ALS and therapeutic implications
Halkidis, Konstantine (2013) Structural changes in HIV-1 Env that promote viral membrane fusion
Heine, Erin M (2013) The role and timing of aberrant polyglutamine-expanded androgen receptor proteolysis in cell models of spinal and bulbar muscular atrophy
Huegel, Julianne (2013) Heparan sulfate-dependent mechanisms of normal and pathological skeletogenesis
Jaremko, Kellie Marie (2013) Identifying novel targets in opioid addiction: Pre-clinical and clinical studies
Lawrence, Tessa M (2013) Innate immune recognition of rabies virus: Defining the role of the inflammasome and interferon stimulated genes
Martz, Matthew K (2013) Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in mitosis and required for the proper completion of abscission
Nikbakht, Neda (2013) Influence of BLyS on Peripheral B Lymphocyte Tolerance
Ritter, David M (2013) Kv3.4 channel function and modulation in nociceptors: Novel insights into the pathophysiology of neuropathic pain
Sanders, Jeffrey Michael (2013) Physics-Based Modeling of Engineered Biopolymers for Monitoring Gene Expression in Disease
Sato, Takahiro (2013) Prolactin-Jak-Stat Signaling Pathways in Breast Cancer
Sussman, Robyn T (2013) The epigenetic modifier Usp22 regulates the transition of embryonic stem cells from self-renewal to differentiation via transcriptional repression of SOX2
Tran, Cassie M (2013) Regulation and Function of CCN2 in the Intervertebral Disc: A Critical Anabolic Factor in Nucleus Pulposus Cells
Vagnozzi, Ronald J (2013) Cardiac Troponin I-interacting Kinase (TNNI3K/CARK) Adversely Regulates Injury, Cell Death and Oxidative Stress in the Ischemic Heart
Wanjalla, Celestine N (2013) Rabies virus-based HIV-1 vaccine vector: impact of antigen presenting cells and immunostimulatory molecules
Whinston, Elizabeth Rogers (2013) Non-Canonical MAP Kinase Signaling and Meiotic Development in Saccharomyces cerevisiae
Dissertations & Theses from 2012
Abel, Ethan Vincent (2012) The role of FOXD3 in melanoma and response to RAF/MEK inhibitors
Conde, Angela (2012) Cyclophilin A, dynein light chain 3, and HIV-1 capsid: Defining elements of host-pathogen interactions and roles in viral replication
Danilo, Christiane (2012) Impact of Cholesterol and Lipoproteins on Breast Cancer
Dickinson, Gregory S (2012) Determining the role of Toll-like receptors in innate and adaptive immune responses to Borrelia hermsii and other antigenic targets of T cell-independent humoral immunity
Dippold, Rachael P (2012) Adaptation to ethanol dysregulates hepatic miRNA expression and alters the dynamic response of miRNAs during liver regeneration
Donaldson, Joshua Michael (2012) Improving the efficacy and side effect profile of therapeutic antibodies
Gold, Jessica I (2012) G Protein-Coupled Receptor Kinase 5 is a Novel Requirement for Maladpative Cardiac Remodeling and Heart Failure
Gomme, Emily A (2012) Harnessing the power of recombinant rabies viruses to make safer vaccines and study viral clearance from the brain
Juliana, Christine A (2012) Characterization of the NLRP3 Inflammasome: Inhibitors, Activators, and Priming
Kidd, Sarah K (2012) Protection of Dopaminergic Cells From 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/ 1-methyl-4-phenylpyridinium Toxicity by Histone Deacetylase Inhibitors
Rivadeneira, Dayana B (2012) Novel roles of the RB-pathway in human cancers: Modifying disease progression and establishing new therapeutic opportunities
Robinson, Tara M (2012) Nonclassical antigen processing and the implications for autoimmunity and infection
Schiewer, Matthew J (2012) AR, cell cycle, and DDR: Mechanisms and impact on cancer progression
Shah, Supriya (2012) Gene-environment Interactions and Novel Therapeutic Interventions in Prostate Cancer
Swope, David (2012) The Role of Plakoglobin and β-catenin in Mechano-Electrical Coupling of the Heart
Trimmer, Casey (2012) New Insights into the Molecular and Cellular Functions of Caveolin-1 in Skin Cancer
Valentino, Michael A (2012) An Intestinal Prouroguanylin-Hypothalamic GUCY2C Axis Mediates Nutrient-Induced Satiety
Watkins, Aubrey (2012) The role of Akt isoforms in BCR-ABL induced chronic myeloid leukemia
Wixted, Josephine Fox (2012) Understanding the many facets of RET/PTC oncogene activity in thyroid carcinoma: Transformation, inflammation, and antigenicity
Dissertations & Theses from 2011
Bourgo, Ryan J (2011) The impact of RB deficiency on hepatocyte biology and tumorigenesis
Carpenter, Richard L (2011) Arsenic-Induced Cell Transformation and Angiogenesis Requires NADPH Oxidase Isoform 2-Derived Reactive Oxygen Species
Colombo, Matthew J (2011) Analysis of B1b lymphocyte-mediated protective immunity
Comber, Joseph D (2011) MHC class II restricted processing of endogenous antigens during viral infection
Dean, Jeffry L. (2011) Therapeutic CDK4/6 inhibition in breast cancer and the importance of reestablishing cell cycle control through RB activation
Gibbons, Ahmara Vivian (2011) Epithelial-specific programming of the microenvironment by guanylyl cyclase C regulates intestinal architecture
Jensen, Deborah Anne (2011) The Effects of Expression of Thermolabile R789C and R992C Collagen II Mutants on Cell Behavior and Extracellular Matrix Structure and Function
Joshi, Amita (2011) A Comparative Analysis of Human T Cell Responses To Adenoviral Early And Late Proteins
Ketonis, Constantinos (2011) Antibiotic Modification of Native Grafts: Improving upon nature's scaffolds
Maxwell, Christina R (2011) Characterization of a rat model of chronic headache
Neely, Robert John (2011) Mechanisms of Ret/PTC 3-induced pro-inflammatory signaling
Phani, Sudarshan (2011) Gene expression studies of the VTA in an animal model of Parkinson's disease and the emergence of gremlin as a dopaminergic neuroprotective factor
Remakus, Sanda S (2011) Mechanisms of memory CD8+ T cell protection from an acute lethal viral disease
Roth, Jacquelyn Jinan (2011) Insertional Mutagenesis as a Tool for Identifying and Characterizing Novel Candidate Cancer Genes
Yersak, Jill M (2011) The 11S proteasomal activator REGγ Impacts polyglutamine-expanded androgen receptor aggregation and toxicity in cell models of spinal and bulbar muscular atrophy
Dissertations & Theses from 2010
Ahmed, Noreen T (2010) Regulation of middle meiotic gene expression by the Sum1 repressor in Saccharomyces cerevisiae
Brown, Timothy B (2010) In vivo analysis of cell-autonomous versus non-cell-autonomous contributions to neuronal dysfunction in disorders of the basal ganglia
Castellini, Meryl A (2010) DNA mismatch repair in Plasmodium falciparum: A potential mechanism for accelerated drug resistance
Coffey, Francis J (2010) Antigen-Driven B Cell Differentiation and Mechanisms of Peripheral Tolerance During the T Cell-Dependent Immune Response
Faul, Elizabeth J (2010) A comprehensive analysis of interferon-beta's role in shaping the immunogenicity and pathogenicity of rabies virus: Development of a novel vaccine vector
Lin, Jieru Egeria (2010) GUCY2C Opposes Premalignant Transformation in Intestine by Regulating PTEN-PI3K/AKT Signaling
McIlhenny, Stephen Edward (2010) The use of adult adipose-derived stem cells in the creation of a tissue engineered vascular bypass graft
Metzler-Wilson, Kristen (2010) S100A1 competes with calmodulin for calmodulin binding proteins, CaV1.2 and SK2 channels
Michal, Allison M (2010) Novel roles of GRKs and arrestins in cell cycle regulation and breast cancer
Pavlides, Stephanos (2010) Caveolin-1 in Human Disease: The Roles of Caveolin-1 in Cancer and Atherosclerosis
Popov, Vladimir M (2010) The Cell Fate Determination Factor DACH1 In Breast Cancer
Rosenberg, Stephen M (2010) Analysis of the function of FADD in hematopoietic stem cells, lineage development and hematopoietic function
Ryder, Amy (2010) Stat5 transcription factors in human breast cancer: Prognosis, tamoxifen response prediction and gene regulation
Shin, Marcus (2010) Regulation of meiotic development in Saccharomyces cerevisiae by the meiosis-specific Ime2 protein kinase
Siglin, Amanda E (2010) Biophysical and in vivo characterization of the dynein-dynactin interaction; implications for multiple modes of regulation
Silver, Hannah (2010) Multiple Genome Stability Roles for SIZ-dependent Sumoylation in Saccharomyces cerevisiae
Smolock, Amanda R (2010) The roles of calpain and protein kinase C in type 1 diabetic vascular dysfunction
Testa, James S. (2010) Elucidation of MHC class II-restricted antigen processing pathways using influenza virus epitopes
Turner, Kevin R (2010) Type I collagen-integrin interactions in angiogenesis
Waldron, Todd J (2010) A role for Myb in BCR-ABL(p190)-induced leukemogenesis: Regulation of Arf suppression through transcriptional activation of BMI1
Dissertations & Theses from 2009
Ambrose-Lanci, Lisa M (2009) Influence of opioid and estrogen systems on cocaine withdrawal in females
Banini, Bubu Ama (2009) Upregulation of fetal hemoglobin in adult-derived erythroid progenitors
Gallagher-Colombo, Shannon (2009) Multifunctional roles of lactate transporters in wound healing and metastasis
Heo, Soyoung (2009) Exploring p53 protein -protein interactions as targets for chemotherapy
Hu, Rong (2009) F -box proteins and co-factors of SCF E3 ubiquitin ligases in melanoma
Kahle, Kristen M (2009) Kinetics of HIV-1 Fusion Inhibition: Implications for Viral Resistance and the Design of Improved Fusion Inhibitors
Kern, Ronald C (2009) Novel insights into arrestin mediated receptor trafficking
Matullo, Christine (2009) Double trouble: How simultaneous immune challenges can result in CNS disease
Moore, Michael (2009) Regulation of the transcriptional repressor Sum1 by the meiosis-specific kinase Ime2 in Saccharomyces cerevisiae
O'Connell, Amy E (2009) Neutrophils and macrophages in the immune response to parasitic helminths
Shuda, Kristy (2009) Molecular basis of aneuploidy: Functions of the aurora kinases, Rad51c, and CREB binding protein in female meiosis
Woulfe, Kathleen Camille (2009) Deletion of GSK-3β in vivo: Revealing the role of this signal integrator in cardiomyocyte hypertrophy and proliferation
Zahm, Adam M (2009) Induction of the osteocytic phenotype: The influence of oxygen on bone cell maturation and survival
Zoeller, Jason Joseph (2009) Perlecan coordinates developmental angiogenesis
Zuzga, David S (2009) Guanylyl cyclase C remodels metastatic architecture through vasodilator-stimulated phosphoprotein
Dissertations & Theses from 2008
Appel, Michael Jay (2008) Approaches toward the investigation of T cell specificities and antigenic determinants in an MHC-matched mouse GVHD model
Beal, Allison M (2008) T cell-mediated cytotoxicity: Understanding the mechanism of effective delivery of a poison pill
Busillo, John M. (2008) Characterizing the Dynamics and Functional Role of Site-Specific Phosphorylation of G Protein-Coupled Receptors
Castorino, John Joseph (2008) Functional dissection of the c-myc mRNA coding region instability determinant
Champagne, Kelly (2008) Structure, folding and engineering of 5-helix, a designed HIV-1 entry inhibitor
Chen, Yingying (2008) Prostaglandin D2 differentially regulates functions of human NK cell subsets through distinct receptors
Crouthamel, Marykate (2008) Role of a polybasic motif in plasma membrane targeting and signaling of G protein α subunits
DeGeorge, Brent Robert (2008) Investigating the role of the adenylyl cyclase inhibitory G protein alpha subunit (Gαi2) in dysfunctional myocardium
Dougherty, Kevin Joseph (2008) A novel integral voltage sensor-interacting protein: Shedding light on the gating mechanisms of somatodendritic Kv channels
Johnston, Danika M (2008) A new mechanism for transcriptional regulation by nuclear hormone receptors during Drosophila development
Kerr, Bethany Amber (2008) The roles of the Rho GTPase protein Rac-1 in cell morphology and function during chondrocyte maturation
Lazarus, Michelle Denise (2008) A New Model For Hemoglobin ingestion and transport by the Human Intraerythrocytic Malaria Parasite, Plasmodium falciparum
Leonard, Michelle (2008) N-cadherin junction formation drives lens fiber cell differentiation and morphogenesis
Martini, Jeffrey S (2008) Uncovering G protein-coupled receptor kinase-5 as a novel histone deacetylase kinase
Pulmanausahakul, Rojjanaporn (2008) Pathogenicity determinants of rabies virus and their function in the pathogenesis of rabies
Ratanadilok Na Phuket, Thanawath (2008) Expression of Kv4 channels in dorsal root ganglion neurons: Major determinants of the A-type potassium current
Riley, Kristen Marie (2008) Regulation of apoptosis by p53 and the ecdysone receptor co-activator TRR in Drosophila
Roy, Anirban (2008) Immune evasion by silver-haired bat rabies virus and implications for treatment
Rudoy, Carla Ann (2008) Targeting Adrenergic Receptors in the Treatment of Cocaine Withdrawal-Related Anxiety
Waselus, Maria (2008) Regulation of the dorsal raphe nucleus serotonin system by the stress related peptide corticotropin-releasing factor
Dissertations & Theses from 2007
Cesarone, Gregory V (2007) Insulin receptor substrate 1, a novel oncogene target in breast cancer
Grabocka, Elda (2007) RGS-RhoGEFs: Interactions with G proteins and identification of novel subcellular locations and function
Pao, Christina S (2007) Mechanism of G protein-coupled receptor kinase binding and activation by G protein-coupled receptors
Phares, Timothy W (2007) Mechanism of immune clearance of virus from the central nervous system in the absence of disease
Pratt, Craig Herbert (2007) Transcriptional regulatory network analysis of retinal pigment epithelial cells during epithelial-mesenchymal transformations
Pufnock, Jeffrey S (2007) The immunological effects of a thyroid oncogene on tumor progression
Schug, Zachary Tiberius (2007) Inter-domain Associations and Gating of the Inositol 1,4,5-trisphosphate Receptor
Tan, Gene S (2007) The Dynein Light Chain 8 Binding Motif of Rabies Virus Phosphoprotein Promotes Efficient Viral Transcription
Terkhorn, Shawn Patrick (2007) Hypoxia inducible factor and prolyl hydroxylase regulation of growth plate function
Dissertations & Theses from 2006
Boland, Genevieve Marie (2006) Molecular characterization of adult human mesenchymal stem cell differentiation: The role of Wnt signaling
Bucaro, Michael A (2006) Bone cell survival in microgravity: The effects of vector -averaged gravity on the osteoblast
Casta, Louis John (2006) Function of the structure-specific metallonuclease flap endonuclease-1 in the Plasmodium falciparum DNA base excision repair pathway
Charbonneau, Nicole Rene (2006) Expression and interactions of hMLH3 in DNA repair
Elliott, Aaron Matthew (2006) The function of CREB -binding protein in germline development
Evans, Stella R (2006) The CLCA family of calcium-activated chloride channels and roles in the eye
Franke, Aaron S (2006) Myosin crossbridge kinetics and the mechanism of catch: Single turnover of myosin-bound ADP in catch muscle
McKenna, Philip M (2006) Characterization and immunogenicity of recombinant rhabdoviral vaccine vectors expressing HIV-1 and SIV envelope proteins
Milano, Shawn K (2006) Arrestin-2: Structure and function
Palmitessa, Aimee (2006) In vivo characterization of Caenorhabditis elegans arrestin
Planey, Sonia Lobo (2006) Steroid receptors and lymphoma cell apoptosis
Plesa, Gabriela (2006) The effect of antigen dose and viral cytopathicity on CD8 T cell responses
Schindler, Karen (2006) Regulation of the meiosis-specific Ime2 protein kinase in Saccharomyces cerevisiae
Smith, Mary Ellen (2006) Rabies virus as an immunostimulatory carrier molecule for vaccination against anthrax
Steger, H. Kirby (2006) Kinetic restriction of HIV-1 entry inhibition
Weber, Gregory F (2006) Survival and apoptotic-related signaling pathways regulate lens cell differentiation
Wolfe, Henry R (2006) Design, synthesis and analysis of ligands for guanylyl cyclase C
Dissertations & Theses from 2005
Anderson, David William (2005) The interactions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment and age with ganglioside therapy on the nigrostriatal dopamine system
Bungard, David (2005) Molecular-genetic analysis of the role of the RSC chromatin remodeling complex during sporulation in Saccharomyces cerevisiae
Datto, Jeffrey P (2005) Inhibiting glutamate excitotoxicity in spinal cord injury
Drakas, Robert A (2005) Identification of proteins associated with IRS-1using a newly developed tandem affinity purification technique
Duffy, Kevin T (2005) Perturbation of oncogenic orthologs in zebrafish
Karpinich, Natalie Olena (2005) The functions of the proteins Bax and Bid in apoptosis
Kerepesi, Laura A (2005) Innate and adaptive immune-mediated resistance to larval Strongyloides stercoralis
Lubbe, Wilhelm Johannes (2005) Guanylyl cyclase C activity inhibits colorectal carcinoma cell metastatic seeding of the lung by a matrix metalloproteinase-9-dependent mechanism
O'Brien, Christopher Joseph (2005) Characterization of a mouse model of spinal and bulbar muscular atrophy and biochemical analysis of neuronal intranuclear inclusions
Owens, Nafeesa Hadiyah Hunt (2005) Nuclear and mitochondrial regulation of cellular differentiation: Roles of serum response factor and tumor suppressor p53
Simsek, Ender (2005) The role of alpha-glucosidase mediated N-linked glycan processing in the secretion and degradation of hepatitis B virus envelope proteins
Smith, Sheryl T (2005) Function of the TAC1 histone modification complex, in Drosophila
Takida, Satoshi (2005) Lipid modifications and membrane trafficking of G protein alphabetagamma subunits and beta5RGS7
Zook, Matthew B (2005) Immunological implications of recoding: Significance and utility of the CD8+ T cell response to epitopes produced as a result of ribosomal frameshifting
Dissertations & Theses from 2004
Abdollahi, Touraj (2004) The effects of TRAIL and interleukin-8 on survival in ovarian cancer
Coleman, Cynthia Marie (2004) Role of growth/differentiation factor 5 in embryonic limb cartilage development
Crumm, Sara E (2004) Energy metabolism in the regenerating rat liver following partial hepatectomy: Rapid changes in adenine nucleotides and AMP -activated protein kinase signaling
Day, Peter William (2004) Characterization of the interaction between Galphaq and GRK2
DiGuglielmo, Matthew DiPasquantonio (2004) Tissue-specific transcriptional regulation of guanylyl cyclase C expression: Relation to intestinal epithelial cell dynamics
Goodrich, Adrienne J (2004) Construction of a novel self-inactivating gene activating vector: Splicing and non-encapsidation of vector RNA
Guo, Yin (2004) Studies on the role of mitochondria in the regulation of cell death
Jones, Stephen Charles (2004) The immunobiology of graft-versus-host disease across a minor histocompatibility antigen barrier
Li, Wan-Ju (2004) A biodegradable, three-dimensional nanofibrous scaffold for cartilage tissue engineering: Fabrication, characterization, and applications
Loza, Matthew J (2004) The common functional maturation pathway of natural killer and T cells
Martin, Eric Santos (2004) Genetic and molecular characterization of the BCSC-1 candidate tumor suppressor gene
Ottey, Michelle A (2004) The FHIT tumor suppressor gene: A functional role in apoptosis and cell cycle response
Razmara, Marjaneh (2004) Ice and card containing proteins: Dancing between life and death
Ruiz-Stewart, Inez (2004) Adenine nucleotide regulation of soluble guanylyl cyclase: Coupling nitric oxide signaling to cell metabolism
Stalker, Timothy J (2004) A novel role for the calcium-dependent protease calpain in the vascular dysfunction of hyperglycemia and diabetes
Sweeney, Shawn M (2004) Mechanisms of collagen I-endothelial cell interactions during the tube-formation phase of angiogenesis
Tewari, Mona K (2004) Processing of exogenous and endogenous influenza virus glycoproteins for MHC class II restricted presentation
Tomkowicz, Brian E (2004) Transformation by the human herpesvirus-8 oncoprotein, Kaposin
Tungaturthi, Parithosh K (2004) HIV-1 Vpr: Implications in AIDS Pathogenesis
Dissertations & Theses from 2003
Boehning, Darren (2003) Structure-function relationships in inositol 1,4,5-trisphosphate receptor calcium channels
Booth, Gregory M (2003) Acute hyperglycemia stimulates leukocyte-endothelium interactions in vivo: Role of nitric oxide and p-selectin
Caterson, Edward J (2003) Human bone marrow-derived progenitor cells for cartilage tissue engineering
Cheung, Mitchell (2003) The identification and characterization of candidate genes for Tourette and bipolar disorders
Cifarelli, Christopher Paul (2003) Characterization and functional analysis of N-cadherin ectodomain shedding during retinal development
Desai, Anup M (2003) Glutamate receptors in the striatum and recovery from experimental Parkinsonism
Emlet, David R (2003) Novel functions of individual epidermal growth factor receptor autophosphorylation sites in receptor regulation and signal transduction
Kim, You-Me (2003) Regulation of Arrestins in G Protein-Coupled Receptor Signal Transduction Pathways
Schiffman, Jonathan S (2003) Expression and function of cadherins in normal and pathological retina
Silverman, Karen A (2003) Identification and analysis of colorectal cancer susceptibility genes in the Apcmin mouse model
Tili, Esmerina (2003) The role of Akt in T cell development and function
Dissertations & Theses from 2002
Alexander, Peter G (2002) The role of paraxis in somitogenesis and carbon monoxide-induced axial skeletal teratogenesis
Beck, Edward J (2002) Modulation of A-type potassium channel inactivation gating: Structural switches and novel subunits
Foley, Heather Dawn (2002) Rhabdovirus-based vectors as an HIV-1 vaccine
Kazerounian, Shideh (2002) Periplakin, an autoantigen in paraneoplastic pemphigus and pemphigus foliaceus, an intermediate filament-binding protein, and a component of the insoluble structures of epidermal keratinocytes
Kazerounian, Shiva (2002) Integration of cyclic GMP and calcium signaling
Krisak, Lisa Ann (2002) Analysis of the role of cadherins in retinoblastoma tumor cell adhesion and growth
McGettigan, James P. (2002) Cellular immune responses against HIV-1 proteins expressed by a highly attenuated rabies-virus-based vaccine vector
Naso, Michael Francis (2002) Transcriptional regulation and developmental expression of collagen type VII in keratinocytes
Nesti, Leon J (2002) Identification and functional characterization of a novel TGF-β1 activated calcium signaling pathway in human osteoblasts
Patterson, Anthony Edward (2002) Graft-versus-myeloid leukemia responses in murine bone marrow transplantations
Schaber, Michael (2002) The dynamic expression and activation of Smk1 during sporulation in Saccharomyces cerevisiae requires a Cdc28-independent activity of Cak1
Stubbs, Matthew (2002) The E2F1 Transcription Factor, the ZF87 Transcription Factor, and the Control of Cell Cycle Transit
Dissertations & Theses from 2001
Cortese, Stacey Christine (2001) The role of the epidermal growth factor receptor in the growth and differentiation of the retinal pigment epithelium
DeLise, Anthony Michael (2001) N-cadherin mediated cell -cell interactions during cellular condensation and chondrogenesis in embryonic chick limb development
Fei, Peiwen (2001) Role of WIP1 in WTP53-induced G2/M arrest
McAleer, Mary Frances (2001) The role of metallothionein in apoptosis of human trophoblastic cells
Park, Jason (2001) Tissue-specific expression of guanylyl cyclase C is regulated by the caudal-related homeodomain protein CDX2
Walker, Janice Lynn (2001) Examination of the regulatory roles of α6 integrin in lens cell differentiation
Dissertations & Theses from 2000
Ansari, Sameer Ahmad (2000) HIV-1 TAT-mediated transcription through TAR RNA: Role of YB-1 and cell cycle regulated NF-kB in glial cells
Halak, Brian Keith (2000) The role of interleukin-10 in immune escape by a murine transitional cell carcinoma
Woodward, Wendy Ann (2000) Regulation of embryonic limb mesenchymal chondrogenesis: Cell adhesion and Wnt signaling
Dissertations & Theses from 1999
Antonyak, Marc A (1999) Elevated JNK activation contributes to transformation and resistance to apoptosis in an in vitro model of transformation and in primary brain tumors
Carman, Christopher Vincent (1999) Characterization of novel G protein -coupled receptor kinase interactions and functions
Chepenik, Lara Gayle (1999) Mechanisms by which the cellular protein, Pur-alpha, and HIV-1 Tat mediate transcription of viral genes
Choi, Eugene Jinkyu (1999) Adhesion molecules mediate the ability of human polymorphonuclear neutrophils to proteolytically penetrate a basement membrane-like barrier
Edling, Andrea Elizabeth (1999) The effect of small molecular inhibitors of CD4 on experimental allergic encephalomyelitis
Goodman, Oscar Baylin (1999) Clathrin lattice assembly and adaptor recruitment in receptor-mediated endocytosis
Gradia, Scott David (1999) Signaling human mismatch repair by the formation of a hMSH2 -hMSH6 sliding DNA clamp
Haltiwanger, Brett Maher (1999) Characterization of a DNA base excision repair pathway in the malaria parasite Plasmodium falciparum: From RIPs to repair
Jiang, An (1999) The construction and applications of cell -type -specific retroviral gene -transfer vectors derived from spleen necrosis virus: From in vitro to in vivo
Kang, Jason Jongho (1999) Apoptotic caspase activation in the yeast Saccharomyces cerevisiae
Kouba, David Jonathan (1999) Transcriptional regulation of the human alpha2(I) collagen (COL1A2) gene by tumor necrosis factor-alpha and interferon-gamma
Krupnick, Jason Garrett (1999) Molecular mechanisms of regulation of G protein-coupled receptor signaling by arrestins
Kundu, Mondira (1999) Mutual interactions between HIV-1 and the host cell cycle: Implications for the neuropathogenesis of ADC
Neary, Catherine Louise (1999) The role of the cytoskeleton in cell death
Reed, Charles Christopher (1999) Ligand recognition in mutant proteins
Safak, Mahmut (1999) A 23-base-pair sequence element and its role in JC virus gene transcription
Serio, Dawn Marie (1999) Novel HIV-1 therapeutic agents based on virion-targeted viral proteins
Shah, Asit K (1999) Effects of transforming growth factor beta-1 and bone morphogenetic protein-2 on osteoblasts at the bone-biomaterial interface
Steelman, Scott (1999) Members of the MEIS1 homeoprotein family are involved in binding the laminin B1 enhancer
Ukropec, Jon Alec (1999) Fluid shear stress-induced reorganization of adherens junctions in human endothelial cells
Wherry, Edward John (1999) The role of tripeptidyl peptidase II in MHC class I-restricted antigen processing and the effect of epitope density of CD8(+) T cell priming
Dissertations & Theses from 1998
Bach, Tami Lee (1998) Identification of a novel interaction between the N-terminal domain of fibrin and VE-cadherin: Its role in angiogenesis
Bennett, Ian Moore (1998) Natural killer cell differentiation
Chianese-Bullock, Kimberly A (1998) Two MHC class II-restricted epitopes are processed in distinct endocytic compartments as a result of the acid-induced structural changes in a viral glycoprotein
Garcia, Ramon John (1998) Activation mechanisms of phospholipase D; an ethanol-metabolizing enzyme
Handler, Melissa (1998) Expression of the heparan sulfate proteoglycan perlecan during murine embryogenesis and tumorigenesis
Hershberger, Marcia E (1998) Placental 54 kDa Ca(2+) binding protein: Regulation of expression and function in trophoblast differentiation and calcium homeostasis
Howard-Claudio, Candace Michelle (1998) The effects ofRB2/p130 on tumorigenesis
Jerng, Henry Hungtao (1998) Mechanism of inactivation in brain potassium channels: Molecular gates and shutters
Lawe, Deirdre C (1998) The molecular and cellular characterization of Nck, an SH2/SH3 adaptor protein, in signal transduction
Lucas, Kimberly Anne (1998) Pathways of lipopolysaccharide-induced prostaglandin E(2) production in human microvascular endothelial cells
MacLachlan, Timothy Kenneth (1998) Characterization of thePITALRE/CDK9 and PISSLREcdc2-related kinases
Mendrola, Jeannine M (1998) Characterization of the receptor protein tyrosine phosphatase gamma gene product
Nossuli, Tareck Omar (1998) Effects of peroxynitrite, a reactive oxygen species, in myocardial reperfusion injury
Phiel, Christopher Jon (1998) Elucidation of the mechanism and pathways promoting intestinal smooth muscle cell differentiation
Rencic, Adrienne (1998) Molecular models for studying CNS associated tumors and dysmyelination
Taddeo, Frank J (1998) A comparative study of the modes of activation of protein kinase C
Trelka, Darin Patrick (1998) The ins and outs of macromolecular transport in malaria-infected erythrocytes
Veneziale, Robert William (1998) Organization of beta(1) integrin and N-cadherin mediated adhesion complexes during lens cell differentiation
Wagner, Marisa (1998) Genetic analysis of a mitogen-activated protein kinase required for spore morphogenesis in Saccharomyces cerevisiae
Wubah, Judith Afedua (1998) A model forp53 gene-teratogen interaction in early mouse embryos
Xu, Shi-Qiong (1998) Purification and identification of a growth factor that sustains the growth of fibroblasts null for the IGF-I receptor
Dissertations & Theses from 1997
Brigandi, Richard A (1997) Antibody- and complement-mediated immunity to infective and autoinfective third stage larvae of Strongyloides stercoralis
Chen, Paul Chih-Hsueh (1997) Structural and functional analysis of the two human tumor necrosis factor receptors
Choksi, Swati (1997) Structure-based designed CD8 peptide analogs inhibit both in vitro and in vivo CD8(+) T cell responses
Denker, Andrew Evan (1997) Chondrogenic activity of transforming growth factor-beta(1) and bone morphogenetic protein-2 on multipotential mesenchymal cells
Deshmane, Sujata Praful (1997) Mechanisms underlying receptor-effector coupling of guanylyl cyclase C
Engelhard, Andrew G (1997) The role of the B-myb gene in differentiation
Evanko, Daniel Stephen (1997) Characterization of the human beta(1)-adrenergic receptor gene and its transcriptional regulation
Finnegan, Alysia Argeson (1997) Molecular characterization of the hypervariable yellow(A(hvy)) allele at the murine agouti locus and investigation of factors influencing phenotypic variability
Gersh, Meryl Hope (1997) The phenotypic mapping of the cat-like cry observed in the cri-du-chat syndrome and molecular characterization of the proposed critical region
Haas, Andrew Robert (1997) Chondrogenic induction by bone morphogenetic protein-2: Involvement of N-cadherin-associated functions
Hall, James Perry (1997) Investigations into mitogen-activated protein (MAP) kinase signal transduction pathways in Saccharomyces cerevisiae
Jena, Nilamani (1997) Structure-function analysis of BCL2(alpha) and characterization of BMP-7 null mice
Koblish, Michael (1997) Development of a murine model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) susceptibility for quantitative trait locus mapping
Koch, Ute (1997) Inhibition of bone marrow and skin graft rejection by a synthetic CD4-CDR3 peptide analog in murine transplantation models
Limardo, Maria Isabel (1997) Molecular genetics of the 180-kDa bullous pemphigoid antigen (BPAG2/COL17A1), a transmembrane protein of the basement membrane zone of the stratifying squamous epithelia
Loudon, Robert Peter (1997) Expression and characterization of the G protein-coupled receptor kinase GRK6
MacPhee-Pellini, Melina (1997) Secretory phospholipase A2: A candidate for the MOM1 locus, a major modifier of APC(Min)-induced intestinal neoplasia
Marini, Joseph C (1997) A CD4-CDER3 peptide analog inhibits both primary and secondary CD4T cell responses in experimental allergic encephalomyelitis
Martinez, Robert Vincent P (1997) Cloning and characterization of the DR-nm23 gene and its associated product, a novel member of thenm23 gene family
Moskow, John Joseph (1997) Identification and characterization of Meis1, a common site of viral integration involved in murine myeloid leukemia
Parkinson, Scott James (1997) Adenine nucleotide regulation of receptor guanylyl cyclases: Application to interrupt Escherichia coli heat-stable entertoxin-dependent signalling mediating secretory diarrhea
Raj, Ganesh Venkataram (1997) The molecular pathogenesis of demyelination and CNS tumors induced by the neurotropic papovavirus, JCV
Sang, Nianli (1997) Characterization of the transcriptional regulatory functions of the transforming region of the adenovirus E1A oncoprotein
Sell, Leslie Jean (1997) The molecular characterization of chromosome 18 abnormalities associated with specific phenotypes
Slavinsky, Christopher W (1997) Characterization and analysis of the murine cartilage oligomeric matrix protein (COMP) gene
Strathdee, Gordon Ronald (1997) Molecular and cytogenetic analysis of the 18q-syndrome
Thiyagarajan, Manimekalai Mohanasundari (1997) Characterization of Ustilago maydis topoisomerase I: Purification, cloning, biochemical and kinetic analysis
Victoria, Teresa (1997) Molecular characterization of the canine model for globoid cell leukodystrophy (Krabbe disease) and study of the effects of human polymorphisms on the activity of murine galactocerebrosidase
Yuan, Constance Miao-Leng (1997) The human COL1A1/COL2A1 chimeric gene in transgenic mice: Analysis of themRNA expression and the apparent inhibition of translation from the construct
Dissertations & Theses from 1996
Abdullah, Fizan (1996) mob-1: A novel mediator of ARDS
Basu, Soumitra (1996) Cellular pharmacology of oligonucleotide analogs
Berger, B.S., Marc Adam Thomas Jefferson University (1996) Role of Immunodominant T Cell Responses to Minor Histocompatibility Antigens in a Mouse Model of Graft-Versus-Host Disease
Berger, Marc Adam (1996) Role of immunodominant T cell responses to minor histocompatibility antigens in a mouse model of graft-versus-host disease
Bullock, Timothy Nicholas James (1996) MHC class I-restricted cryptic epitopes: Their production and immunogenicity
Chen, Nancie Nien-Tsyr (1996) Identification and characterization of cellular proteins regulating transcription of human neurotropic virus, JCV
Connelly, Patrick Raymond (1996) Retinoid signaling and cell cycle regulation during murine palate development
Dutta, Seema (1996) Chromatin associated proteins of Ustilago maydis
Earley, James Joseph (1996) High-throughput DNA sequence analysis for thr investigation of genetic diseases by the candidate gene approach
Hazel, Betsy Ann (1996) Hydroquinone, a major bone marrow metabolite of benzene, induces granulopoiesis in a mouse model: Possible role in benzene-induced acute myelogenous leukemia
Hill, Jason Eric (1996) Partial analysis of sequences expressed by human osteoblasts in vitro using differential display-PCR (DD-PCR)
Jordan, Kelly Lynn (1996) Structural and functional analysis of domains within the E2F1 transcription factor
Kastury, Veera Kumar (1996) Cloning and characterization of loci surrounding the familial renal cell carcinoma t(3;8) translocation break point
Kauh, Eunkyung Ann (1996) Isolation and characterization of suppressors of camptothecin toxicity in Saccharomyces cerevisiae
Kennedy, Susan Heather (1996) Differential regulation of collagenase and type I collagen gene expression by basic fibroblast growth factor in human smooth muscle cells
Lee, Mimi Meihui (1996) Biochemical and functional analysis of N-cadherin phosphorylation in embryonic chick tissues
Megonigal, Maureen D (1996) Mutant DNA topoisomerase I-induced lethality in Saccharomyces cerevisiae
Mylet, Johanna C (1996) The role of RAD1 in repeat-mediated double strand break repair of variable number tandem repeats (VNTRs) in Saccharomyces cerevisiae
Pastor-Soler, Nuria Maria (1996) Metachromatic leukodystrophy among the Navajo Indians: A study of the arylsulfatase A gene mutations present in this population
Reardon, Brian James (1996) The molecular and genetic characterization of the DAT1 gene product of Saccharomyces cerevisiae
Rock, Matthew James (1996) Molecular genetic analysis of N-cadherin structure and function
Rotman, Harris Laeb (1996) Protective immunity to larval Strongyloides stercoralis in a mouse model
Ryan, Robert Frederick (1996) Zinc finger proteins: A study of linker region importance, DNA, and RNA binding characteristics
Silos, Stephanie A (1996) Transcriptional regulation of epidermal-specific cell adhesion molecules
Suri, Dorothy E (1996) Modulation of expression of human urokinase-type plasminogen activator by HTLV-1 protein tax, spermine and glipizide
Swantek, Jennifer Lynn (1996) IGF-I receptor signaling in mammalian cell growth and transformation
Weaver, Eric James (1996) A molecular and genetic analysis of variable number tandem repeat (VNTR) recombination in Saccharomyces cerevisiae
Yang, Naibo (1996) Voltage-activated gating of sodium channels
Dissertations & Theses from 1995
Lee, Sharon Sunmi (1995) In vivo gene therapy: Using a recombinant vaccinia virus as a cytokine gene delivery system to localized murine tumors
Vandenberg, Philipp (1995) Cloning and characterization of the murinecol11a2 gene, itscDNA, and its functional analysis in transgenic mice
Dissertations & Theses from 1994
Davenpeck, Kelly Lyn (1994) Role of P-selectin and nitric oxide in leukocyte-endothelial interaction in the rat mesenteric microcirculation
Liddell, Rebecca Ann (1994) Analysis of isoactin gene expression during normal and abnormal gastrointestinal smooth muscle development
Pastorino, John Gaetano (1994) Mitochondrial deenergization and the subsequent formation of the permeability transition are critical to hypoxic cell killing
Dissertations & Theses from 1992
Dorer, Douglas R (1992) A genetic and molecular analysis of the Triplo-lethal locus of Drosophila melanogaster
Dissertations & Theses from 1990
Hathaway, Charles Briggs (1990) Sources and control of release of plasma catecholamines in the American eel, Anguilla rostrata (Teleostei)
Dissertations & Theses from 1989
Bower, David B (1989) In vitro effects of sera from stressed rats on growth parameters of normal and transformed rat cells
Dissertations & Theses from 1987
FRITCH, DEAN FRANCIS (1987) THE EFFECTS OF HYDROCORTISONE ON FOS, MYC AND RAS EXPRESSION IN IMR-90 FIBROBLASTS
Dissertations & Theses from 1984
PER, STEVEN ROBERT (1984) PURIFICATION OF ANTIGEN-ANTIBODY COMPLEXES FROM SELECTED SPECIES BY STAPHYLOCOCCAL PROTEIN A
TSAY, BEELEIN LIN (1984) REGULATION OF MURINE RESPONSES TO THE KNOWN SEQUENCE POLYMER POLY (L-TYROSINE- L-GLUTAMIC ACID- L-ALANINE-GLYCINE)
Dissertations & Theses from 1983
ELLIS, JOHN SIDNEY (1983) SYNTHESIS, CHARACTERIZATION AND IMMUNOLOGICAL STUDIES OF SIX KNOWN-SEQUENCE POLYMERS CONTAINING TYROSINE, GLUTAMIC ACID, ALANINE, AND GLYCINE
