A novel combination of three codon inserts in the pol coding region of HIV-1 RNA was identified in a highly antiretroviral experienced study subject with HIV-1 infection. A one codon insert was observed in the protease region between codon 40 and 41 simultaneously with a two codon insert present in the reverse transcriptase region at codon 69.
Jordan, Parris S; Poon, Art; Eron, Joseph; Squires, Kathleen; Ignacio, Caroline; Richman, Douglas D; and Smith, Davey M, "A novel codon insert in protease of clade B HIV type 1." (2009). Division of Infectious Diseases and Environmental Medicine Faculty Papers. Paper 3.