Health-related quality of life in the gender, race, and clinical experience trial.

Authors

Judith Feinberg, Department of Internal Medicine, University of Cincinnati College of MedicineFollow
Michael Saag, Division of Infectious Disease, Department of Medicine, University of Alabama at BirminghamFollow
Kathleen Squires, Division of Infectious Diseases and Environmental Medicine, Jefferson Medical College, Thomas Jefferson UniversityFollow
Judith Currier, avid Geffen School of Medicine, University of California, Los AngelesFollow
Robert Ryan, Medical Affairs Biometrics, Tibotec Inc.
Bruce Coate, Medical Affairs Biometrics, Tibotec Inc.
Joseph Mrus, Clinical Affairs, Tibotec TherapeuticsFollow

Document Type

Article

Publication Date

8-28-2011

Comments

This article has been peer reviewed. It was published in: AIDS Research and Treatment.

Volume 2011, 2011, Article number 349165.

The published version is available at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166720/. DOI: 10.1155/2011/349165.

Copyright © 2011 Judith Feinberg et al.

Abstract

Background. We report health-related QoL (HRQoL) from GRACE (Gender, Race, And Clinical Experience) study by sex and race over 48 weeks. Methods. 429 treatment-experienced adults (HIV-1 RNA ≥ 1000 copies/mL) received darunavir/ritonavir 600/100 mg twice daily plus an appropriate background regimen. QoL was measured by the Functional Assessment of HIV Infection (FAHI) questionnaire. Results. 67% women and 77% men, including 67.4% black, 76.0% Hispanic, and 73.8% white patients, completed the trial. Baseline total FAHI scores were similar between sexes and races. Total FAHI of the entire population improved by Week 4 (P < .05); near-maximum changes obtained by Week 12 were maintained through Week 48. Women and black patients demonstrated larger improvements in total FAHI versus men, and Hispanic and white patients, respectively. Conclusion. HRQoL improved in all sex and racial/ethnic groups. Sex-based and race-based differences in improvements in FAHI subscales may provide insight into subtle differences of HIV-1 and treatment on HRQoL in different populations.

Recommended Citation

Feinberg, Judith; Saag, Michael; Squires, Kathleen; Currier, Judith; Ryan, Robert; Coate, Bruce; and Mrus, Joseph, "Health-related quality of life in the gender, race, and clinical experience trial." (2011). Division of Infectious Diseases and Environmental Medicine Faculty Papers. Paper 4.
https://jdc.jefferson.edu/didem/4