Dissecting the Daily Feeding Pattern: Peripheral CLOCK/CYCLE Generate the Feeding/Fasting Episodes and Neuronal Molecular Clocks Synchronize Them

Authors

Akiko Maruko, Thomas Jefferson University
Koichi M Iijima
Kanae Ando

Document Type

Article

Publication Date

10-6-2023

Comments

This article is the author's final published version in iScience, Volume 26, Issue 11, 2023, Article number 108164.

The published version is available at https://doi.org/10.1016/j.isci.2023.108164.

Copyright © 2023 The Authors

Abstract

A 24-h rhythm of feeding behavior, or synchronized feeding/fasting episodes during the day, is crucial for survival. Internal clocks and light input regulate rhythmic behaviors, but how they generate feeding rhythms is not fully understood. Here we aimed to dissect the molecular pathways that generate daily feeding patterns. By measuring the semidiurnal amount of food ingested by single flies, we demonstrate that the generation of feeding rhythms under light:dark conditions requires quasimodo (qsm) but not molecular clocks. Under constant darkness, rhythmic feeding patterns consist of two components: CLOCK (CLK) in digestive/metabolic tissues generating feeding/fasting episodes, and the molecular clock in neurons synchronizing them to subjective daytime. Although CLK is a part of the molecular clock, the generation of feeding/fasting episodes by CLK in metabolic tissues was independent of molecular clock machinery. Our results revealed novel functions of qsm and CLK in feeding rhythms in Drosophila.

Recommended Citation

Maruko, Akiko; Iijima, Koichi M; and Ando, Kanae, "Dissecting the Daily Feeding Pattern: Peripheral CLOCK/CYCLE Generate the Feeding/Fasting Episodes and Neuronal Molecular Clocks Synchronize Them" (2023). Department of Neuroscience Faculty Papers. Paper 81.
https://jdc.jefferson.edu/department_neuroscience/81

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Language

English