Document Type
Article
Publication Date
12-2021
Abstract
Reactive granulomatous dermatitis (RGD) is a rare dermatosis with a variety of cutaneous manifestations unified by a dermal granulomatous infiltrate on histology. Rheumatoid arthritis and autoimmune disease are classic associations, but an increasing number of cases have been attributed to covert malignancy. Only 41 cases of paraneoplastic RGD have been documented to our knowledge and we present an additional case that manifested eight months prior to the diagnosis of ovarian cancer and clinically mimicked morphea. Histopathologic examination identifying palisaded CD68+ cells and collagen degeneration are helpful in diagnosing this entity which may mimic a host of other cutaneous processes, including metastatic disease. Cancer-directed therapies have been successful in clearing paraneoplastic RGD with or without the addition of corticosteroids, as RGD severity may be driven by the underlying malignancy. This case highlights the importance of utilizing histopathology to confirm the diagnosis given its nonspecific clinical findings, as well as the importance of considering malignancy and metastatic disease in patients diagnosed with RGD regardless of their cancer history.
Recommended Citation
Sherban, Alexander; Cha, Jisun; and Jones, Elizabeth, "Reactive granulomatous dermatitis associated with ovarian cancer and a review of its role as a harbinger for malignancy" (2021). Department of Dermatology and Cutaneous Biology Faculty Papers. Paper 162.
https://jdc.jefferson.edu/dcbfp/162
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Language
English
Comments
This is the final published version of the article from the Dermatology Online Journal, Volume 27, Issue 12, 2021
The article can also be found on the journal's website: https://doi.org/10.5070/D3271256704
Copyright. The Authors.
Publication made possible in part by support from the Jefferson Open Access Fund