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This article has been peer reviewed. It was published in: Journal of mammary gland biology and neoplasia.

Volume 17, Issue 1, March 2012, Pages 59-64.

The published version is available at DOI: 10.1007/s10911-012-9246-4. Copyright © Springer.


Small non-coding RNAs include siRNA, miRNA, piRNA and snoRNA. The involvement of miRNAs in the regulation of mammary gland tumorigenesis has been widely studied while the role for other small non-coding RNAs remains unclear. Here we summarize the involvement of miRNA in breast cancer onset and progression through regulating the cell cycle and cellular proliferation. The regulation of breast cancer stem cells and tumor regeneration by miRNA is reviewed. In addition, the emerging evidence demonstrating the involvement of piRNA and snoRNA in breast cancer is briefly described.

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