Document Type
Article
Publication Date
9-18-2020
Abstract
The essential G1-cyclin, CCND1, is a collaborative nuclear oncogene that is frequently overexpressed in cancer. D-type cyclins bind and activate CDK4 and CDK6 thereby contributing to G1-S cell-cycle progression. In addition to the nucleus, herein cyclin D1 was also located in the cytoplasmic membrane. In contrast with the nuclear-localized form of cyclin D1 (cyclin D1NL), the cytoplasmic membrane-localized form of cyclin D1 (cyclin D1MEM) induced transwell migration and the velocity of cellular migration. The cyclin D1MEM was sufficient to induce G1-S cell-cycle progression, cellular proliferation, and colony formation. The cyclin D1MEM was sufficient to induce phosphorylation of the serine threonine kinase Akt (Ser473) and augmented extranuclear localized 17β-estradiol dendrimer conjugate (EDC)-mediated phosphorylation of Akt (Ser473). These studies suggest distinct subcellular compartments of cell cycle proteins may convey distinct functions.
Recommended Citation
Chen, Ke; Jiao, Xuanmao; Ashton, Anthony; Di Rocco, Agnese; Pestell, Timothy G; Sun, Yunguang; Zhao, Jun; Casimiro, Mathew C; Li, Zhiping; Lisanti, Michael P; McCue, Peter; Shen, Duanwen; Achilefu, Samuel; Rui, Hallgeir; and Pestell, Richard G, "The membrane-associated form of cyclin D1 enhances cellular invasion" (2020). Department of Cancer Biology Faculty Papers. Paper 169.
https://jdc.jefferson.edu/cbfp/169
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
32948740
Language
English
Comments
This article is the author’s final published version in Oncogenesis, Volume 9, Issue 9, September 2020, Article number 83.
The published version is available at https://doi.org/10.1038/s41389-020-00266-y. Copyright © Chen et al.