Authors

Clotilde Théry, Institut Curie
Kenneth W. Witwer, The Johns Hopkins University School of Medicine
Elena Aikawa, Brigham and Women’s Hospital; Harvard Medical School
Maria Jose Alcaraz, University of Valencia
Johnathon D. Anderson, University of California, Davis
Ramaroson Andriantsitohaina, Université d ’ Angers
Anna Antoniou, German Centre for Neurodegenerative Diseases; University Hospital Bonn
Tanina Arab, Université de Lille
Fabienne Archer, University of Lyon,
Georgia K. Atkiin-Smith, La Trobe University
D. Craig Ayre, Atlantic Cancer Research Institute; Mount Allison University
Jean-Marie Bach, Université Bretagne Loire,
Daniel Bachurski, University of Cologne
Hossein Baharvand, Royan Institute for Stem Cell Biology and Technology; University of Science and Culture, ACEC
Leonora Balaj, Massachusetts General Hospital
Shawn Baldacchino, University of Malta
Natalie N. Bauer, University of South Alabama
Amy A. Baxter, La Trobe University
Mary Bebawy, University of Technology Sydney,
Carla Beckham, University of Rochester
Apolonija Bedina Zavec, National Institute of Chemistry, Ljubljana, Slovenia
Abderrahim Benmoussa, Université Laval
Anna C. Berardi, Ospedale Santo Spirito
Paolo Bergese, CSGI - Research Center for Colloids and Nanoscience; INSTM - National Interuniversity Consortium of Materials Science and Technology; University of Brescia
Ewa Bielska, University of Birmingham
Cherie Blenkiron, University of Auckland
Sylwia Bobis-Wozowicz, Jagiellonian University Cracow
Eric Boilard, Université Laval
Wilfrid Boireau, FEMTO-ST Institute
Antonella Bongiovanni, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR) of Italy
Francesc E. Borràs, Germans Trias i Pujol Research Institute; Germans Trias i Pujol University Hospital; Universitat Autònoma de Barcelona
Steffi Bosch, Université Bretagne Loire
Chantal M. Boulanger, INSERM UMR-S 970; Université Paris Descartes
Xandra Breakefield, Harvard Medical School
Andrew M. Breglio, Icahn School of Medicine at Mount Sinai; National Institutes of Health
Meadhbh Á. Brennan, Harvard University; Université de Nantes
David R. Brigstock, Nationwide Children’s Hospital; The Ohio State University
Alain Brisson, CNRS-Université de Bordeaux
Marike L.D. Broekman, Haaglanden Medical Center; Leiden University Medical Center; Massachusetts General Hospital
Jacqueline F. Bromberg, Memorial Sloan Kettering Cancer Center; Weill Cornell Medicine
Paulina Bryl-Górecka, Lund University
Shilpa Buch, University of Nebraska Medical Center
Amy H. Buck, University of Edinburgh
Dylan Burger, Kidney Research Centre; Ottawa Hospital Research Institute; University of Ottawa
Sara Busatto, Mayo Clinic; University of Brescia
Dominik Buschmann, Technical University of Munich
Benedetta Bussolati, University of Torino
Edit I. Buzás, MTA-SE Immuno-Proteogenomics Research Groups; Semmelweis University
James Bryan Byrd, The University Of Michigan
Giovanni Camussi, University of Torino
David R.F. Carter, Oxford Brookes University
Sarah Caruso, La Trobe University
Lawrence W. Chamley, University of Auckland
Yu-Ting Chang, National Taiwan University Hospital
Chichen Chen, National Tsing Hua University
Shuai Chen, Leibniz Institute for Farm Animal Biology
Lesley Cheng, La Trobe University
Andrew R. Chin, Cedars-Sinai Medical Center
Aled Clayton, Cardiff University
Stefano P. Clerici, UNICAMP, Institute of Biology, Campinas, Brazil
Alex Cocks, Cardiff University
Emanuele Cocucci, The Ohio State University
Robert J. Coffey, Vanderbilt University Medical Center
Anabela Cordeiro-da-Silva, University of Porto
Yvonne Couch, University of Oxford
Frank A.W. Coumans, Academic Medical Centre of the University of Amsterdam
Beth Coyle, The University of Nottingham
Rossella Crescitelli, University of Gothenburg
Miria Ferreira Criado, University of São Paulo
Crislyn D’ Souza-Schorey, University of Notre Dame
Saumya Das, Massachusetts General Hospital
Amrita Datta Chaudhuri, The Johns Hopkins University School of Medicine
Paola de Candia, IRCCS MultiMedica, Milan
Eliezer F. De Santana Junior, The Sociedade Beneficente Israelita Brasileira Albert Einstein,
Olivier De Wever, Cancer Research Institute Ghent; Ghent University
Hernando A. del Portillo, Institució Catalana de Recerca i Estudis Avançats (ICREA); Institut d ’ Investigació Germans Trias i Pujol (IGTP); ISGlobal, Hospital Clínic - Universitat de Barcelona
Tanguy Demaret, Université Catholique de Louvain
Sarah Deville, Universiteit Hasselt; Vlaamse Instelling voor Technologisch Onderzoek (VITO)
Andrew Devitt, Aston University
Bert Dhondt, Cancer Research Institute Ghent; Ghent University Hospital; Ghent University
Dolores Di Vizio, Cedars-Sinai Medical Center
Lothar C. Dieterich, ETH Zurich, Institute of Pharmaceutical Sciences
Vincenza Dolo, University of L ’ Aquila
Ana Paula Dominguez Rubio, Universidad de Buenos Aires
Massimo Dominici, TPM of Mirandola; University of Modena and Reggio Emilia
Mauricio R. Dourado, University of Campinas; University of Oulu
Tom A.P Driedonks, Utrecht University
Filipe V. Duarte, Exogenus Therapeutics, Cantanhede
Heather M. Duncan, McGill University
Ramon M. Eichenberger, James Cook University
Karin Ekström, University of Gothenburg
Samir El Andaloussi, Evox Therapeutics Limited; Karolinska Institute
Celine Elie-Caille, FEMTO-ST Institute
Uta Erdbrügger, University of Virginia Health System
Juan M. Falcón-Pérez, CIC bioGUNE, CIBEReh; IKERBASQUE Research Science Foundation
Farah Fatima, University of São Paulo
Jason E. Fish, Toronto General Hospital Research Institute; University of Toronto
Miguel Flores-Bellver, University of Colorado
András Försönits, Semmelweis University
Annie Frelet-Barrand, FEMTO-ST Institute
Fabia Fricke, German Cancer Research Center (DKFZ); University Hospital Heidelberg
Gregor Fuhrmann, Helmholtz-Centre for Infection Research; Helmholtz-Institute for Pharmaceutical Research Saarland; Saarland University
Susanne Gabrielsson, Karolinska Institute
Ana Gámez-Valero, Germans Trias i Pujol Research Institute (IGTP); Universitat Autònoma de Barcelona
Chris Gardiner, University College London
Kathrin Gärtner, Helmholtz Center Munich German Research Center for Environmental Health
Raphael Gaudin, INSERM U1110; Université de Strasbourg
Yong Song Gho, POSTECH (Pohang University of Science and Technology)
Bernd Giebel, University Hospital Essen, University Duisburg-Essen
Caroline Gilbert, Université Laval
Mario Gimona, Paracelsus Medical University
Ilaria Giusti, University of L ’ Aquila
Deborah C.I. Goberdhan, University of Oxford
André Görgens, Evox Therapeutics Limited; Karolinska Institute; University Hospital Essen, University Duisburg-Essen
Sharon M. Gorski, BC Cancer, Canada ’ s Michael Smith Genome Sciences Centre; Simon Fraser University
David W. Greening, La Trobe University
Julia Christina Gross, University Medical Center Göttingen
Alice Gualerzi, IRCCS Fondazione Don Carlo Gnocchi
Gopal N. Gupta, Loyola University Chicago
Dakota Gustafson, University of Toronto
Aase Handberg, Aalborg University Hospital; Aalborg University
Reka A. Haraszti, University of Massachusetts Medical School
Paul Harrison, University of Birmingham
Hargita Hegyesi, Semmelweis University
An Hendrix, Cancer Research Institute Ghent; Ghent University,
Andrew F. Hill, La Trobe University
Fred H. Hochberg, Scintillon Institute, La Jolla; University of California, San Diego
Karl F. Hoffmann, Aberystwyth University
Beth Holder, Imperial College London; MRC The Gambia
Harry Holthofer, University Clinic Eppendorf
Baharak Hosseinkhani, Hasselt University
Guoku Hu, University of Nebraska Medical Center
Yiyao Huang, Nanfang Hospital, Southern Medical University; The Johns Hopkins University School of Medicine
Veronica Huber, Fondazione IRCCS Istituto Nazionale dei Tumor
Stuart Hunt, The University of Sheffield
Ahmed Gamal-Eldin Ibrahim, Cedars-Sinai Medical Center
Tsuneya Ikezu, Boston University School of Medicine
Jameel M. Inal, University of Hertfordshire
Mustafa Isin, Istanbul University Oncology
Alena Ivanova, German Cancer Research Center (DKFZ)
Hannah K. Jackson, The University of Nottingham
Soren Jacobsen, Copenhagen Lupus and Vasculitis Clinic; University of Copenhagen
Steven M. Jay, University of Maryland at College Park
Muthuvel Jayachandran, Mayo Clinic
Guido Jenster, Department of Urology, Rotterdam
Lanzhou Jiang, La Trobe University
Suzanne M. Johnson, University of Manchester
Jennifer C. Jones, National Institutes of Health
Ambrose Jong, Children’s Hospital of Los Angeles; University of Southern California Keck School of Medicine
Tijana Jovanovic-Talisman, City of Hope Comprehensive Cancer Center, Beckman Research Institute
Stephanie Jung, German Research Center for Environmental Health
Raghu Kalluri, University of Texas MD Anderson Cancer Cente
Shin-ichi Kano, The Johns Hopkins University School of Medicine
Sukhbir Kaur, National Institutes of Health, National Cancer Institute
Yumi Kawamura, National Cancer Center Research Institute, Tokyo; University of Tsukuba
Evan T. Keller, The University of Michigan
Delaram Khamari, Semmelweis University
Elena Khomyakova, École Normale Supérieure; Federal Research and Clinical Center of Physical-Chemical Medicine, Moscow
Anastasia Khvorova, University of Massachusetts Medical School
Peter Kierulf, Oslo University Hospital
Kwang Pyo Kim, Kyung Hee University
Thomas Kislinger, Princess Margaret Cancer Centre; University of Toronto
Mikael Klingeborn, Duke University
David J. Klinke II, West Virginia University
Miroslaw Kornek, German Armed Forces Central Hospital; Saarland University Medical Center
Maja M. Kosanović, University of Belgrade
Árpád Ferenc Kovács, Semmelweis University
Eva-Maria Krämer-Albers, University of Mainz
Susanne Krasemann, University Medical Center Hamburg-Eppendorf
Mirja Krause, Hudson Institute of Medical Research, Melbourne
Igor V. Kurochkin, Central Research Laboratories, Sysmex Co., Kobe, Japan
Gina D. Kusuma, Hudson Institute of Medical Research; Monash University
Sören Kuypers, Hasselt University
Saara Laitinen, Finnish Red Cross Blood Service
Scott M. Langevin, Cincinnati Cancer Center; University of Cincinnati College of Medicine
Lucia R. Languino, Thomas Jefferson UniversityFollow
Joanne Lannigan, University of Virginia
Cecilia Lässer, University of Gothenburg
Louise C. Laurent, University of California, San Diego
Gregory Lavieu, Institut Curie
Elisa Lázaro-Ibáñez, AstraZeneca, Discovery Sciences, IMED Biotech Unit, Gothenburg
Soazig Le Lay, Université d ’ Angers
Myung-Shin Lee, Eulji University
Yi Xin Fiona Lee, Genome Institute of Singapore,
Debora S. Lemos, Federal University of Paraná
Metka Lenassi, University of Ljubljana
Aleksandra Leszczynska, University of California, San Diego
Isaac T.S. Li, University of British Columbia Okanagan
Ke Liao, University of Nebraska Medical Center
Sten F. Libregts, University of Cambridge School of Clinical Medicine
Erzsebet Ligeti, Semmelweis University
Rebecca Lim, Hudson Institute of Medical Research; Monash University
Sai Kiang Lim, Institute of Medical Biology (IMB)
Aija Linē, Latvian Biomedical Research and Study Centre
Karen Linnemannstöns, University Medical Center Göttingen
Alicia Llorente, Oslo University Hospital-The Norwegian Radium Hospital
Catherine A. Lombard, Université Catholique de Louvain
Magdalena J. Lorenowicz, Utrecht University
Ákos M. Lörincz, Semmelweis University
Jan Lötvall, University of Gothenburg
Jason Lovett, Stellenbosch University
Michelle C. Lowry, Trinity College Dublin
Xavier Loyer, NSERM UMR-S 970; Université Paris Descartes
Quan Lu, Harvard University
Barbara Lukomska, Mossakowski Medical Research Centre
Taral R. Lunavat, University of Bergen
Sybren L.N. Maas, Utrecht University
Harmeet Malhi, Mayo Clinic
Antonio Marcilla, Universitat de València
Jacopo Mariani, Università degli Studi di Milano
Javier Mariscal, Cedars-Sinai Medical Center
Elena S. Martens-Uzunova, Department of Urology, Rotterdam
Lorena Martin-Jaular, Institut Curie
M. Carmen Martinez, Université d ’ Angers
Vilma Regina Martins, A.C.Camargo Cancer Center, São Paulo
Mathilde Mathieu, Institut Curie
Suresh Mathivanan, La Trobe University
Marco Maugeri, University of Gothenburg
Lynda K. McGinnis, University of Southern California, Los Angeles
Mark J. McVey, SickKids Hospital, Toronto; University of Toronto
David G. Meckes, Jr., Florida State University College of Medicine
Katie L. Meehan, University of Western Australia
Inge Mertens, University of Antwerp; Vlaamse Instelling voor Technologisch Onderzoek (VITO)
Valentina R. Minciacchi, Georg-Speyer-Haus Institute for Tumor Biology and Experimental Therapy
Andreas Möller, QIMR Berghofer Medical Research Institute
Malene Møller Jørgensen, Aalborg University Hospital; EVSEARCH.D
Aizea Morales-Kastresana, National Institutes of Health, National Cancer Institute,
Jess Morhayim, Erasmus MC, Rotterdam
François Mullier, Namur Thrombosis and Hemostasis Center (NTHC); Université Catholique de Louvain
Maurizio Muraca, University of Padova
Luca Musante, University of Virginia Health System
Veronika Mussack, Technical University of Munich
Dillon C. Muth, The Johns Hopkins University School of Medicine
Kathryn H. Myburgh, Stellenbosch University
Tanbir Najrana, Brown University
Muhammad Nawaz, University of Gothenburg
Irina Nazarenko, German Cancer Consortium (DKTK); Medical Center - University of Freiburg
Peter Nejsum, Aarhus University
Christian Neri, Sorbonne Université
Tommaso Neri, University of Pisa
Rienk Nieuwland, Academic Medical Centre of the University of Amsterdam
Leonardo Nimrichter, Universidade Federal do Rio de Janeiro
John P. Nolan, Scintillon Institute, La Jolla,
Esther N.M. Nolte-’ t Hoen, Utrecht University
Nicole Noren Hooten, National Institutes of Health, National Institute on Aging,
Lorraine O’Driscoll, Trinity College Dublin
Tina O’Grady, University of Liège
Ana O’Loghlen, Queen Mary University of London
Takahiro Ochiya, National Cancer Center Research Institute, Division of Molecular and Cellular Medicine, Tokyo
Martin Olivier, McGill University
Alberto Ortiz, IIS-Fundacion Jimenez Diaz-UAM; Spanish Kidney Research Network, REDINREN; Universidad Autónoma de Madrid
Luis A. Ortiz, University of Pittsburgh
Xabier Osteikoetxea, AstraZeneca, Discovery Sciences, IMED Biotech Unit, Cambridge
Ole Ostegaard, Statens Serum Institut; University of Copenhagen
Matias Ostrowski, University of Buenos Aires
Jaesung Park, POSTECH (Pohang University of Science and Technology)
D. Michiel Pegtel, Amsterdam University Medical Centers
Hector Peinado, Spanish National Cancer Research Center (CNIO)
Francesca Perut, IRCCS - Istituto Ortopedico Rizzo
Michael W. Pfaffl, Technical University of Munich
Donald G. Phinney, The Scripps Research Institute-Scripps Florida
Bartijn C.H. Pieters, Radboud University Medical Center
Ryan C. Pink, Oxford Brookes University
David S. Pisetsky, Duke University Medical Center; Durham VAMC
Elke Pogge von Strandmann
Iva Polakovicova, Philipps University Marburg
Ivan K.H. Poon, La Trobe University
Bonita H. Powell, The Johns Hopkins University School of Medicine
Ilaria Prada, NR Institute of Neuroscience
Lynn Pulliam, University of California, San Francisco; Veterans Affairs Medical Center, San Francisco
Peter Quesenberry, The Warren Alpert Medical School of Brown University
Annalisa Radeghieri, CSGI - Research Center for Colloids and Nanoscience; University of Brescia
Robert L. Raffai, Department of Veterans Affairs, San Francisco; University of California, San Francisco
Stefania Raimondo, University of Palermo
Janusz Rak, McGill University
Marcel I. Ramirez, Instituto Oswaldo Cruz; INSTM - National Interuniversity Consortium of Materials Science and Technology
Graça Raposo, Institut Curie
Morsi S. Rayyan, University of Michigan Medical School
Neta Regev-Rudzki, Weizmann Institute of Science
Fran L. Ricklefs, University Medical Center Hamburg-Eppendorf
Paul D. Robbins, University of Minnesota Medical School
David D. Roberts, National Institutes of Health, National Cancer Institute
Silvia C. Rodrigues, CNC, Coimbra; Exogenus Therapeutics, Cantanhede, Portugal
Eva Rohde, Paracelsus Medical University; Spinal Cord Injury & Tissue Regeneration Center Salzburg
Sophie Rome, University of Lyon
Kasper M.A. Rouschop, Maastricht University
Aurelia Rughetti, Sapienza University of Rome
Ashley E. Russell, West Virginia University
Paula Saá, American Red Cross
Susmita Sahoo, Icahn School of Medicine at Mount Sinai
Edison Salas-Huenuleo, Advanced Center for Chronic Diseases, Santiago; University of Chile
Catherine Sánchez, Clínica las Condes
Julie A. Saugstad, Oregon Health & Science University
Meike J. Saul, Technische Universität Darmstadt
Raymond M. Schiffelers, University Medical Center Utrecht
Raphael Schneider, University of Toronto
Tine Hiorth Schøyen, The Johns Hopkins University School of Medicine
Aaron Scott, University of Bristol
Eriomina Shahaj, Fondazione IRCCS Istituto Nazionale dei Tumor
Shivani Sharma, University of California, Davis; University of California, Los Angeles
Olga Shatnyeva, AstraZeneca, Discovery Sciences, IMED Biotech Unit, Gothenburg
Faezeh Shekari, Royan Institute for Stem Cell Biology and Technology
Ganesh Vilas Shelke, University of Gothenburg
Ashok K. Shetty, Olin E. Teague Veterans’ Medical Center; Texas A&M University College of Medicine
Kiyotaka Shiba, Cancer Institute of JFCR, Tokyo
Pia R-M Siljander, University of Helsinki
Andreia M. Silva, INEB - Instituto de Engenharia Biomédica; University of Porto
Agata Skowronek, Maria Sklodowska-Curie Institute
Orman L. Snyder II, Kansas State University
Rodrigo Pedro Soares, René Rachou Institute/FIOCRUZ
Barbara W. Sódar, Semmelweis University
Carolina Soekmadji, QIMR Berghofer Medical Research Institute; The University of Queensland
Javier Sotillo, James Cook University
Philip D. Stahl, Washington University, Saint Louis
Willem Stoorvogel, Utrecht University
Shannon L. Stott, Harvard Medical School; Massachusetts General Cancer Center
Erwin F. Strasser, FAU Erlangen-Nuremberg
Simon Swift, University of Auckland
Hidetoshi Tahara, Hiroshima University
Muneesh Tewari, University of Michigan
Kate Timms, University of Manchester
Swasti Tiwari, Georgetown University; Sanjay Gandhi Postgraduate Institute of Medical Sciences
Rochelle Tixeira, La Trobe University
Mercedes Tkach, Institut Curie
Wei Seong Toh, National University of Singapore
Richard Tomasini, Aix Marseille University
Ana Claudia Torrecilhas, UNIFESP, Departamento de Ciências Farmacêuticas
Juan Pablo Tosar, Institut Pasteur de Montevideo; Universidad de la República, Faculty of Science
Vasilis Toxavidis, Beth Israel Deaconess Medical Center
Lorena Urbanelli, University of Perugia
Pieter Vader, University Medical Center Utrecht
Bas W.M. van Balkom, University Medical Center Utrecht
Susanne G. van der Grein, Utrecht University
Jan Van Deun, Cancer Research Institute Ghent; Ghent University
Martijn J.C. van Herwijnen, Utrecht University
Kendall van Keuren-Jensen, TGen, Neurogenomics Division, Phoenix
Guillaume van Niel, Center for Psychiatry and Neuroscience, INSERM U894
Martin E. van Royen, Erasmus MC, Erasmus Optical Imaging Centre
Andre J. van Wijnen, Mayo Clinic
M. Helena Vasconcelos, University of Porto
Ivan J. Vechetti Jr., University of Kentucky
Tiago D. Veit, Universidade Federal do Rio Grande do Sul
Laura J. Vella, The Florey Institute of Neuroscience and Mental Health, Melbourne; The University of Melbourne
Émilie Velot, UMR 7365 CNRS-Université de Lorraine
Frederik J. Verweij, Center for Psychiatry and Neuroscience, INSERM U894
Beate Vestad, Oslo University Hospital Rikshospitalet; Regional Research Network on Extracellular Vesicles, Oslo; University of Oslo
Jose L. Viñas, Kidney Research Centre; Ottawa Hospital Research Institute; University of Ottawa
Tamás Visnovitz, Semmelweis University
Krisztina V. Vukman, Semmelweis University
Jessica Wahlgren, University of Gothenburg
Dionysios C. Watson, Case Western Reserve University; University Hospitals Cleveland Medical Center
Marca H.M. Wauben, Utrecht University
Alissa Weaver, Vanderbilt University School of Medicine
Jason P. Webber, Cardiff University
Viktoria Weber, Danube University Krems
Ann M. Wehman, University of Würzburg
Daniel J. Weiss, The University of Vermont Medical Center
Joshua A. Welsh, National Institutes of Health, National Cancer Institute
Sebastian Wendt, University Hospital RWTH Aachen
Asa M. Wheelock, Karolinska Institute
Zoltán Wiener, Semmelweis University
Leonie Witte, University Medical Center Göttingen
Joy Wolfram, Chinese Academy of Science; Houston Methodist Research Institute; Mayo Clinic
Angeliki Xagorari, George Papanicolaou Hospital
Patricia Xander, Universidade Federal de São Paulo Campus Diadema
Jing Xu, BC Cancer, Canada ’ s Michael Smith Genome Sciences Centre; Simon Fraser University
Xiaomei Yan, Xiamen University
María Yáñez-Mó, Centro de Biología Molecular Severo Ochoa; Universidad Autónoma de Madrid
Hang Yin, Tsinghua University
Yuana Yuana, Technical University Eindhoven
Valentina Zappulli, University of Padova
Jana Zarubova, Institute of Physiology CAS, Czech Republic
Vytautas Žėkas, Vilnius University
Jian-ye Zhang, Guangzhou Medical University
Zezhou Zhao, The Johns Hopkins University School of Medicine
Lei Zheng, Nanfang Hospital, Southern Medical University
Alexander R. Zheutlin, University of Michigan
Antje M. Zickler, Karolinska Institute
Pascale Zimmermann, Aix-Marseille Université; Leuven University
Angela M. Zivkovic, University of California, Davis
Davide Zocco, Exosomics Siena SpA
Ewa K. Zuba-Surma, Jagiellonian University Cracow

Document Type

Article

Publication Date

1-1-2019

Comments

This article has been peer reviewed. It is the author’s final published version in Journal of Extracellular Vesicles, Volume 8, Issue 1, January 2019, Article number 1535750.

The published version is available at https://doi.org/10.1080/20013078.2018.1535750. Copyright © Théry et al.

Abstract

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points. © 2018, © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.

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Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

Language

English

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Oncology Commons

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