Document Type
Article
Publication Date
October 2007
Abstract
Endocrine signaling via nuclear receptors (NRs) is known to play an important role in normal physiology as well as in human tumor progression. Hormones regulate gene expression by altering local chromatin structure and, thereby, accessibility of transcriptional co-regulators to DNA. Recently it has been shown that non-histone proteins involved in hormone signaling, such as nuclear receptors and NR co-activators, are regulated by acetylation, resulting in their altered transcriptional activity. NAD-dependent protein deacetylases, the sirtuins (Sir2-related enzymes), directly modify NRs. Because sirtuins have been shown to regulate tumor cellular growth, aging, metabolic signaling and endocrine hormone signaling, they might play a role in cancer progression. This review focuses on the role of acetylation and the sirtuins in nuclear hormone receptor signaling.
Recommended Citation
Whittle, James R.; Powell, Michael J.; Popov, Vladimir M.; Shirley, L. Andrew; Wang, Chenguang; and Pestell, Richard G., "Sirtuins, nuclear hormone receptor acetylation and transcriptional regulation" (2007). Department of Cancer Biology Faculty Papers. Paper 13.
https://jdc.jefferson.edu/cbfp/13
Comments
This article has been peer reviewed. It is the authors' final version prior to publication in Trends in Endocrinology and Metabolism 18(9):356-364. The published version is available at http://dx.doi.org/10.1016/j.tem.2007.07.007; copyright © 2007 by Elsevier Ltd.