Low Absolute Risk of Thrombotic and Cardiovascular Events in Outpatient Pregnant Women with COVID-19
Document Type
Article
Publication Date
5-1-2024
Abstract
INTRODUCTION: Pregnancy may contribute to an excess risk of thrombotic or cardiovascular events. COVID-19 increases the risk of these events, although the risk is relatively limited among outpatients. We sought to determine whether outpatient pregnant women with COVID-19 are at a high risk for cardiovascular or thrombotic events.
MATERIALS & METHODS: We analyzed pregnant outpatients with COVID-19 from the multicenter CORONA-VTE-Network registry. The main study outcomes were a composite of adjudicated venous or arterial thrombotic events, and a composite of adjudicated cardiovascular events. Events were assessed 90 days after the COVID-19 diagnosis and reported for non-pregnant women ≤45 years, and for men ≤45 years, as points of reference.
RESULTS: Among 6585 outpatients, 169 were pregnant at diagnosis. By 90-day follow-up, two pregnant women during the third trimester had lower extremity venous thrombosis, one deep and one superficial vein thrombosis. The cumulative incidence of thrombotic events was 1.20 % (95 % confidence interval [CI]: 0.0 to 2.84 %). Respective rates were 0.47 % (95 % CI: 0.14 % to 0.79 %) among non-pregnant women, and 0.49 % (95 % CI: 0.06 % to 0.91 %) among men ≤45 years. No non-thrombotic cardiovascular events occurred in pregnant women. The rates of cardiovascular events were 0.53 % (95 % CI: 0.18 to 0.87) among non-pregnant women, and 0.68 % (95 % CI: 0.18 to 1.18) in men aged ≤45 years.
CONCLUSIONS: Thrombotic and cardiovascular events are rare among outpatients with COVID-19. Although a higher event rate among outpatient pregnant women cannot be excluded, the absolute event rates are low and do not warrant population-wide cardiovascular interventions to optimize outcomes.
Recommended Citation
Bikdeli, Behnood; Krishnathasan, Darsiya; Khairani, Candrika; Bejjani, Antoine; Davies, Julia; Porio, Nicole; Tristani, Anthony; Armero, Andre; Assi, Ali; Nauffal, Victor; Campia, Umberto; Almarzooq, Zaid; Wei, Eric; Ortiz-Rios, Marcos; Zuluaga-Sánchez, Valeria; Achanta, Aditya; Jesudasen, Sirus; Tiu, Bruce; Merli, Geno; Leiva, Orly; Fanikos, John; Grandone, Elvira; Sharma, Aditya; Rizzo, Samantha; Pfeferman, Mariana; Morrison, Ruth; Vishnevsky, Alec; Hsia, Judith; Nehler, Mark; Welker, James; Bonaca, Marc; Carroll, Brett; Goldhaber, Samuel; Lan, Zhou; and Piazza, Gregory, "Low Absolute Risk of Thrombotic and Cardiovascular Events in Outpatient Pregnant Women with COVID-19" (2024). Division of Cardiology Faculty Papers. Paper 150.
https://jdc.jefferson.edu/cardiologyfp/150
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Language
English
PubMed ID
38677791
Included in
Cardiology Commons, Female Urogenital Diseases and Pregnancy Complications Commons, Virus Diseases Commons
Comments
This article is the author's final published version in Thrombosis Research, Volume 237, May 2024, Pages 209 - 215.
The published version is available at https://doi.org/10.1016/j.thromres.2024.02.021.
Copyright © 2024 The Authors