Document Type
Article
Publication Date
11-17-2010
Abstract
Infections are a devastating complication of titanium alloy orthopedic implants. Current therapy includes antibiotic-impregnated bone cement and antibiotic-containing coatings. We hypothesized that daptomycin, a Gram-positive peptide antibiotic, could prevent bacterial colonization on titanium alloy surfaces if covalently bonded via a flexible, hydrophilic spacer. We designed and synthesized a series of daptomycin conjugates for bonding to the surface of 1.0 cm² Ti6Al4V foils through bisphosphonate groups, reaching a maximum yield of 180 pmol/cm². Daptomycin-bonded foils killed 53 ± 5% of a high challenge dose of 3 × 10⁵ cfu Staphylococcus aureus ATCC 29213.
Recommended Citation
Chen, Chang-Po and Wickstrom, Eric, "Self-protecting bactericidal titanium alloy surface formed by covalent bonding of daptomycin bisphosphonates." (2010). Department of Biochemistry and Molecular Biology Faculty Papers. Paper 22.
https://jdc.jefferson.edu/bmpfp/22
PubMed ID
20949909
Comments
This article has been peer reviewed. It is the authors' final version prior to publication in Bioconjugate Chemistry Volume 21, Issue 11, November 2010, Pages 1978-1986. The published version is available at DOI: 10.1021/bc100136e. Copyright © American Chemical Society