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This article has been peer reviewed. It is the authors' final version prior to publication in Nature Chemical Biology 6, 795 - 796 October 18, 2010 The published version is available at DOI: 10.1038/nchembio.459. Copyright © Nature Publishing Group.


Aminoacylation of tRNA is the cellular process for providing aminoacyl donors for the ribosome synthesis of polypeptides. New research highlights an unexpected structural overlap between enzymes involved in this process and those involved in the biosynthesis of cyclodipeptides, an important class of bioactive molecules.

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