Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates.
Document Type Article
This article has been peer reviewed. It was published in: Nature Communications.
2021 Jan 20;12(1):484.
The published version is available at DOI: 10.1038/s41467-020-20783-z
Copyright © 2021, The Author(s).
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Abstract
The tumor suppressor p53 integrates stress response pathways by selectively engaging one of several potential transcriptomes, thereby triggering cell fate decisions (e.g., cell cycle arrest, apoptosis). Foundational to this process is the binding of tetrameric p53 to 20-bp response elements (REs) in the genome (RRRCWWGYYYN
