The origin of protein backbone threading through a topological knot remains elusive. To understand the evolutionary origin of protein knots, in this issue of StructureKo et al. (2019) used circular permutation to untie a knotted protein. They showed that a domain-swapped dimer releases the knot and the associated high-energy state for substrate binding.
Yin, Sitao; Dhital, Brittiny; and Hou, Ya-Ming, "How to Untie a Protein Knot." (2019). Department of Biochemistry and Molecular Biology Faculty Papers. Paper 157.
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