How to Untie a Protein Knot.

Authors

Sitao Yin, Thomas Jefferson UniversityFollow
Brittiny Dhital, Thomas Jefferson UniversityFollow
Ya-Ming Hou, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

8-6-2019

Comments

This article has been peer reviewed. It is the authors' final version prior to publication in Structure, Volume 27, Issue 8, August 2019, Pages 1190-1191.

The published version is available at https://doi.org/10.1016/j.str.2019.07.008. Copyright © Elsevier

Abstract

The origin of protein backbone threading through a topological knot remains elusive. To understand the evolutionary origin of protein knots, in this issue of StructureKo et al. (2019) used circular permutation to untie a knotted protein. They showed that a domain-swapped dimer releases the knot and the associated high-energy state for substrate binding.

Recommended Citation

Yin, Sitao; Dhital, Brittiny; and Hou, Ya-Ming, "How to Untie a Protein Knot." (2019). Department of Biochemistry and Molecular Biology Faculty Papers. Paper 157.
https://jdc.jefferson.edu/bmpfp/157

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

PubMed ID

31390544

Language

English