Selected Works of Barry J. Goldstein, MD, PhD, FACE

My major research interests include:

1. Mechanisms and regulation of insulin receptor signal transduction.
2. Protein-tyrosine phosphatases and the regulation of hormone action.
3. Pathophysiology of insulin-resistant disease states including obesity and Type 2 diabetes mellitus.
4. Mechanisms of the complications of diabetes, including vascular signaling by adiponectin.

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• Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo
• Insulin degradation by adipose tissue. Studies at several levels of cellular organization
• Molecular cloning and expression of a unique receptor-like protein-tyrosine-phosphatase in the leucocyte-common-antigen-related phosphatase family
• The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H₂0₂ and plays an integral role in insulin signal transduction
• Uptake of branched-chain alpha-keto acids in Bacillus subtilis