Influence of the menstrual cycle on the incidence of nausea and vomiting after laparoscopic gynecological surgery: a pilot study.

Authors

Tatjana Simurina, University of Zadar, General Hospital ZadarFollow
Boris Mraovic, Thomas Jefferson UniversityFollow
Neven Skitarelić, University of Zadar
Tatjana Andabaka, University of Zadar, General Hospital Zadar
Zdenko Sonicki, School of Public Health Andrija Štampar, University of ZagrebFollow

Document Type

Article

Publication Date

5-1-2012

Comments

This article has been peer reviewed. It is the authors' final version prior to publication in Journal of Clinical Anesthesia

Volume 24, Issue 3, May 2012, Pages 185-192.

The published version is available at DOI: 10.1016/j.jclinane.2011.07.011. Copyright © Elsevier Inc.

Abstract

STUDY OBJECTIVE: To investigate whether the phase of menstrual cycle influences the incidence of postoperative nausea and vomiting (PONV) in women undergoing general anesthesia for elective laparoscopic gynecological surgery.

DESIGN: Prospective, observational, blinded study.

SETTING: General hospital, Postanesthesia Care Unit, and gynecologic floor room.

PATIENTS: 111 ASA physical status 1 and 2 women, aged 18 to 53 years.

INTERVENTIONS: Patients were classified into three groups according to the phase of menstrual cycle at the time of anesthesia: Group F1: follicular phase (menstrual days 1-8; n = 34); Group O2: ovulatory phase (days 9-15; n = 40); and Group L3: luteal phase (days 16 to end of cycle; n = 37). Anesthetic, postoperative pain management, and antiemetic regimens were standardized.

MEASUREMENTS: Frequency of nausea, vomiting, or both were assessed for early (0-2 hrs). Late PONV (2-24 hrs) along with the use of rescue antiemetic, severity of nausea, and pain.

MAIN RESULTS: In the follicular (n = 34), ovulatory (n = 40) and luteal phase (n = 37) groups, the frequencies of PONV over 24 hours were 35%, 38%, and 14% (P = 0.04), respectively. This was due to differences in the early postoperative period where the frequencies were 21%, 25%, and 3% (P = 0.02), respectively, as frequencies were similar in the late period (15%, 20% and 14%, P = 0.71), respectively. Nausea scores, rescue antiemetic usage, pain scores, and opioid consumption were similar in the groups.

CONCLUSION: Patients in the luteal phase of their menstrual cycle may have a decreased risk of PONV after laparoscopic gynecological surgery in the early postoperative period.

Recommended Citation

Simurina, Tatjana; Mraovic, Boris; Skitarelić, Neven; Andabaka, Tatjana; and Sonicki, Zdenko, "Influence of the menstrual cycle on the incidence of nausea and vomiting after laparoscopic gynecological surgery: a pilot study." (2012). Department of Anesthesiology Faculty Papers. Paper 18.
https://jdc.jefferson.edu/anfp/18

PubMed ID

22459340