Hypercalcemia related to ectopic vitamin D production from a dysgerminoma

Authors

Iqra Iqbal, Abington Jefferson HealthFollow
Muhammad Atique Alam Khan, Abington Jefferson HealthFollow
Puneet Dhillon, Abington Jefferson HealthFollow
Samavia Munir, Abington Jefferson HealthFollow
Dina Nabwani, Bayshore Medical Center

Files

Description

Introduction

While malignancy associated hypercalcemia is a common finding among 20% to 30% of adult patients with breast cancer, lung cancer and multiple myeloma, it happens in less than 5% of female genital tract malignancies. [1] The three most common mechanisms associated with hypercalcemia are: local osteolytic hypercalcemia, humoral hypercalcemia of malignancy (HHM) caused by the parathyroid hormone-related peptide (PTHrP), and other humoral factors including prostaglandin, tumor necrosis factor (TNF), osteoclast activating factor and transforming growth factor (TGF). PTHrP and 1, 25 dihydroxy vitamin D (1, 25 Vit D) have been reported as humoral factors for dysgermininoma. [2] Humoral hypercalcemia of malignancy (HHM) can be caused by ectopic paraneoplastic production of 1, 25 dihydroxy vitamin D due to hyperactivity of 1 alpha-hydroxylase enzyme.

Publication Date

10-26-2019

Keywords

hypercalcemia, dysgerminoma

Disciplines

Medicine and Health Sciences

Comments

Presented at the PA-ACP Southeastern Region Abstract and Doctor's Dilemma Competition

Recommended Citation

Iqbal, Iqra; Khan, Muhammad Atique Alam; Dhillon, Puneet; Munir, Samavia; and Nabwani, Dina, "Hypercalcemia related to ectopic vitamin D production from a dysgerminoma" (2019). Abington Jefferson Health Posters. 3.
https://jdc.jefferson.edu/abingtonposters/3