Document Type
Article
Publication Date
10-14-2024
Abstract
Background: Pulmonary hypertension (PH) can lead to cardiac failure, thereby signif- icantly affecting life expectancy and quality of life. Due to inadequate disease surveillance and risk assessment, clinical challenges persist despite advances in diagnosis and treatment. We aimed to review the potential of high-sensitivity cardiac troponin (hs-cTn) as a biomarker for predicting outcomes in PH patients. Methods: A thorough examination of the PubMed and Google Scholar databases was conducted through March 2023. Studies involving adult PH patients and hsTn as a prognostic indicator of outcomes such as mortality, hospitalization, and disease progression were included, after screening their titles and abstracts. Two independent evaluators extracted data, with the quality assessed using the JBI critical appraisal tool. Results: This review uncovered eight studies that examined the prognostic value of hs-cTn in PH patients. Higher hs-cTn levels were associated with increased mortality and hospitalization rates, according to the studies. The severity of PH, cardiac dysfunction, right ventricular function, and systolic dysfunction were associated with hs-cTn. Multiple studies have demonstrated that hsTn has the potential to identify high-risk PH patients who could benefit from targeted therapies and increased clinical monitoring. Conclusions: This review suggests that hsTn may be a biomarker for PH risk stratification and prognosis. Across PH subtypes, elevated hsTn levels predict poor outcomes. However, large-scale prospective studies are needed to confirm hs-cTn’s function in diagnosing pulmonary hypertension and determine its potential value in treatment.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Ganipineni, Vijay Durga Pradeep; Jitta, Sahas Reddy; Gudiwada, Mohan Chandra Vinay Bharadwaj; Jasti, Jaswanth Rao; Janga, Chaitra; Merugu, Bhavyasri; Bandaru, Revanth Reddy; Puli, Srikanth; Venkata, Vikramaditya Samala; Vasavada, Advait; and Desai, Rupak, "High-Sensitivity Cardiac Troponin [hs-cTn] as a Valuable Biomarker for Pulmonary Hypertension Risk Stratification: A Contemporary Review of the Literature" (2024). Abington Jefferson Health Papers. Paper 111.
https://jdc.jefferson.edu/abingtonfp/111
PubMed ID
39451452
Comments
This article is the author's final published version in Healthcare (Switzerland), Volume 12, Issue 20, October 2024, Article number 2037.
The published version is available at https://doi.org/10.3390/healthcare12202037.
Copyright © 2024 by the authors