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Theses/Dissertations from 2005

Characterization of a mouse model of spinal and bulbar muscular atrophy and biochemical analysis of neuronal intranuclear inclusions., Christopher Joseph O'Brien

In vivo characterization of C. elegans arrestin, Aimee Palmitessa

The effect of antigen does and viral cytopathicity on CD8 T cell responses, Gabriela Plesa

Regulation of the meiosis-specific IME2 protein kinase in Saccharomyces cerevisiae, Karen Schindler

The role of alpha-glucosidase mediated N-linked glycan processing in the secretion and degredation of hepatitus B virus envelope proteins, Ender Simsek

Meis 1 at the boundary between life and death: the context of meis 1 expression can decide between survival and apoptosis, Peter J. Wermuth

The mechanism of psychosine-induced apoptosis and a role for insulin-like growth factor-1 protection in an oliodendrocyte progenitor cell line, Mariam Zaka

Theses/Dissertations from 2004

The effects of trail and interleukin-8 on survival in ovarian cancer, Touraj Abdollahi

Identification of sumo substrates in yeast, Gwendolyn R. Bylebyl

The drosophila trithorax-related protein: a dual-acting histone methyltransferase and nuclear receptor coactivator, Elizabeth Cho

Inhibiting glutamate excitotoxicity in spinal cord injury, Jeffrey P. Datto

Identification of proteins associated with IRS-1 using a newly developed tandem affinity prification technique, Robert A. Drakas

Construction of a novel self-inactivating gene activating vector-splicing and non-encapsidation of vector RNA, Adrienne J. Goodrich

The functions of the proteins BAX and BID in apoptosis, Natalie Olena Karpinich

Innate and adaptive immune-mediated resistance to larval Strongyloides stercoralis, Laura A. Kerepesi

A biodegradable, three-dimensional nanofibrous scaffold for cartilage tissue engineering: fabrication, characterization, and applications, Wan-ju Li

Effect of X-linked inhibitor of apoptosis protein on eye development in Drosophila melanogaster, Julie Nijemh

Hepatitis B virus surface and core antigen specific lymphocyte cytolytic and cytokine responses, and the effects of 5- (and 6-) carboxyfluorescein diacetate succinimidyl ester on lymphocyte function, Elizabeth G. Sweeney

Lipid modifications and membrane trafficking of G protein alpha-beta-gamma subunits and BETA{lcub}5{rcub} RGS7, Satoshi Takida

Processing of exogenous and endogenous influenza virus glycoproteins for MHC class II restricted presentation, Mona K. Tewari

Bioreactivity of orthopaedic implant wear particles: studies on the pathogenesis of wear-mediated osteolysis, Mark L. Wang

Theses/Dissertations from 2003

Acute hyperglycemia stimulates leukocyte-endothelium interactions in vivo: role of no and P-selectin, Gregory M. Booth

Characterization and functional analysis of N-cadherin ectodomain shedding during retinal development, Christopher Paul Cifarelli

The relationship between Pax-1 and N-cadherin during avian somitogenesis and chondrogenesis, Karen L. Clark

Characterization of the interaction between G alpha{lcub}q{rcub} and GRK2, Peter William Day

Role of arrestin binding in alpha 2-adrenergic receptor internalization and signaling, Jessica L. DeGraff

Studies on the role of mitochondria in the regulation of cell death, Yin Guo

The immunology of graft-versus-host disease across a minor histocompatability antigen barrier, Stephen Charles Jones

Periplakin, an autoantigen in paraneoplastic pemphigus and pemphigus foliaceus, an intermediate filament-binding protein, and a component of the insoluble structures of epidermal keratinocytes, Shideh Kazerounian

Integration of cyclic GMP and calcium signaling, Shiva Kazerounian

Genetics and molecular characterization of the BCSC-1 candidate tumor suppressor gene, Eric Santos Martin

The biophysical properties of mismatch and lesion recognition by hMS2-hMS3 and hMSH2-hMSH6, Anthony Mazurek

Charactrerization and immunogenicity of recombinant rhabdoviral vaccine vectors expressing HIV-1 and SIV envelope proteins, Philip M. McKenna

The FHIT tumor suppressor gene: a functional role in apoptosis and cell cycle response, Michelle A. Ottey

Tissue-specific expression of guanylyl cyclase C is regulated by the caudal-related homeodomain protein CDX2, Jason Park

ICE and CARD containing proteins dancing between life and death, Marjaneh Razmara

Adenine nucleotide regulation of soluble guanylyl cyclase: coupling nitric oxide signaling to cell metabolism, Inez Ruiz-Stewart

Expression and function of cadherins in normal and pathological retina, Jonathan S. Schiffman

Function of the TAC1 histone modification complex, in Drosophila, Sheryl T. Smith

A novel role for the calcium-dependent protease calpain in the vascular dysfunction of hyperglycemia and diabetes, Timothy J. Stalker

Mechanisms of collagen I-endothelial cell interactions during tube-formation phase of angiogenesis, Shawn M. Sweeney

The role of Akt in T cell development and function, Esmerina Tili

Characterizationof trabecular bone-derived mesenchymal progenitor cells: chondrogenic mechanisms and applications for cartilage tissue engineering, Richard Tuli

Immunolgical implications of recoding: significance and utility of the CD8+ T cell response to epitopes produced as a result of ribosomal frameshifting, Matthew B. Zook

Theses/Dissertations from 2002

The role of Paraxis in Somitogenesis and Carbon Monoxide-Induced Axial Skeletal Teratogenesis, Peter G. Alexander

The effects of ultraviolet radiation on elastin gene expression Douglas Bennett Brown., Douglas Bennett Brown

Role of growthdifferentiation factor 5 in embryonic limb cartilage development, Cynthia Marie Coleman

Energy metabolism in the regenerating rat liver following partial hepatectomy: rapid changes in adenine nucleotides and AMP-activated protein kinase signaling, Sara E. Crumm

Tissue-specific transcriptional regulation of guanylyl cyclase C expression: relation to intestinal epithelial cell dynamics, Matthew D. Di Guglielmo

Novel functions of individual epidermal growth factor receptor autophosphorylation sites in receptor regulation and signal transduction, David R. Emlet

Regulation of arrestins in G protein-coupled receptor signal transduction pathways, You-Me Kim

Analysis of the role of Cadherins in Retinoblastoma tumor cell adhesion and growth, Lisa Ann Krisak

The Common functional maturation pathway of natural killer and T Cells, Matthew J. Loza

Saccharomyces cerevisiae as a model for characterizing G protein-coupled receptor kinase and G protein interactions with receptors, Beth Noble

Dysregulation of Nuclear-Mitochondrial Integenomic control during ocular teratogeneis, Michael F. O'Hara

Graft-versus-myeloid leukemia responses in murine bone marrow transplantation, Anthony Edward Patterson

Steroid receptors and lymphoma cell apoptosis, Sonia Lobo Planey

The RETPTC3 Fusion Protein: An immunogenic oncoprotein in thyroid carcinoma, Daniel J. Powell

RETPTC3, A thyroid specific oncoprotein, induces proinflammatory cytokine expression and inflammation, John P. Russell

The dynamic expression and activation of Smk1 during sporulation in Saccharomyces cerevisiae requires a Cdc28-independent activity of Cak1, Michael Schaber

The E2F1 Transcription factor, the ZF87 Transcription factor, and the Control of Cell Cycle Transit, Matthew Stubbs

Transformation by the human herpesvirus-8 oncoprotein, kaposin, Brian E. Tomkowicz

Theses/Dissertations from 2001

Modulation of A-type potassium channel inactivation gating: structural switches and novel subunits, Edward J. Beck

Structure-function relationship in inositol 1,4,5-trisphosphate receptor Ca2+ channels Darren Boehning., Darren Boehning

Human bone marrow-derived progenitor cells for cartilage tissue engineering, Edward J. Caterson

The identification and characterization of candidate genes for tourette syndrome and bipolar disorder Mitchell Cheung., Mitchell Cheung

The role of the epidermal growth factor receptor in the growth and differentiation of the retinal pigment epithelium Stacey Christine Cortese., Stacey Christine Cortese

N-Cadherin mediated cell-cell interactions during cellular condensation and chondrogenesis in embryonic chick limb development Anthony M. DeLise., Anthony M. DeLise

Glutamate receptors in the striatum and recovery from experimental parkinsonism, Anup M. Desai

Role of WIP1 in WTP53-induced G2M arrest Peiwen Fei., Peiwen Fei

Rhabdovirus-based vectors as an HIV-1 vaccine Heather Dawn Foley., Heather Dawn Foley


Antisense and gene therapy approaches as an alternative to disulfiram for the treatment of alcohol abuse Eric M. Garver., Eric M. Garver

Molecular genetic approaches to study N-Cadherin function in the retina Yvette Nicole Hickman., Yvette Nicole Hickman

The role of metallothionein in apoptosis of human trophoblastic cells Mary Frances McAleer., Mary Frances McAleer

Transcriptional regulation and developmental expression of collagen type VII in keratinocytes Michael Francis Naso., Michael Francis Naso

The p-Azophenylarsonate response as a model to study peripheral B cell tolerance Evangelia Notidis., Evangelia Notidis

B-myb transgenic mice as a model to study B-Myb function in T cells Mark A. Powzaniuk., Mark A. Powzaniuk

Gamma aminobutyric acid and enkephalin neurotransmission in striatopallidal efferents: relationship to the expression of sensorimotor deficits in experimental parkinsonism Joseph Allen Schroeder., Joseph Allen Schroeder

Regulation of limb mesenchymal chondrogenesis by WNT family of signaling molecules and their putative frizzled receptors Ahmet Cevik Tufan., Ahmet Cevik Tufan

Structural and functional characterization of a novel gene, URG4, upregulated by hepatitis B virus encoded X protein Naciye Lale Satiroglu Tufan., Naciye Lale Satiroglu Tufan

Theses/Dissertations from 2000

Characterization and elimination of the residual HIV-1 virus through novel techniques, Aaron Geist

The role of interleukin-10 in immune escape by a murine transitional cell carcinoma, Brian Keith Halak

The role of interleukin 5 in innate versus adaptive immunity against strongyloides stercoralis in the mouse De'Broski R. Herbert., De'Broski R. Herbert

Cytotoxic T cell effector mechanisms of graft-versus-leukemia and graft-versus-host disease, Michael Harrison Hsieh

Ethanol consumption alters hepatitis B virus activity and associated liver disease in a novel transgenic SCID mouse model, Jonathan David Larkin

Identification and functional characterization of a novel TGF-B1 activated calcium signaling pathway in human osteoblasts, Leon J. Nesti

Regulation of embryonic limb mesenchymal chondrogenesis: cell adhesion and WNT signaling, Wendy A. Woodward

Theses/Dissertations from 1999

Elevated JNK activation contributes to transformation and resistance to apoptosis in an in vitro model of transformation and in primary brain tumors, Marc A. Antonyak

Characterization of the mechanism of fragility at the FHIT locus, Lori R. Berk

Characterization of novel G protein-coupled receptor kinase interactions and functions, Christopher V. Carman

Mechanisms by which the cellular protein, Pur-gas, and HIV-1 Tat mediate transcription of viral genes, Lara G. Chepenik

Adhesion molecules mediate the ability of human polymorphonuclear neutrophils to proteolytically penetrate a basement membrane-like barrier, Eugene J. Choi

The effect of small molecular inhibitors of CD4 on experimental allergic encephalomyelitis, Andrea E. Edling

Signaling human mismatch repair by the formation of a hMSH2-hMSH6 sliding DNA clamp, Scott David Gradia

Characterization of a DNA base excision repair pathway in the malaria parasite Plasmodium falciparum: from RIPs to repair, Brett Maher Haltiwanger

The construction and applications of cell-type-specific retroviral gene-transfer vectors derived from spleen necrosis virus: from IN VITRO to IN VIVO, An Jiang

Apoptotic caspase activation in the yeast Saccharomyces cerevisiae, Jason J. Kang

Molecular mechanisms of regulation of G protein-coupled receptor signaling by arrestins, Jason G. Krupnick

Mutual interactions between HIV-1 and the host cell cycle: implications for the neuropathogenesis of ADC, Mondira Kundu

Ligand recognition in mutant proteins, Charles C. Reed