Document Type
Article
Publication Date
7-13-2024
Abstract
BACKGROUND: Neonatal and early-life gut microbiome changes are associated with altered cardiometabolic and immune development. In this study, we explored Cesarean delivery effects on the gut microbiome in our high-risk, under-resourced Bronx, NY population.
RESULTS: Fecal samples from the Bronx MomBa Health Study (Bronx MomBa Health Study) were categorized by delivery mode (vaginal/Cesarean) and analyzed via 16 S rRNA gene sequencing at four timepoints over the first two years of life. Bacteroidota organisms, which have been linked to decreased risk for obesity and type 2 diabetes, were relatively reduced by Cesarean delivery, while Firmicutes organisms were increased. Organisms belonging to the Enterococcus genus, which have been tied to aberrant immune cell development, were relatively increased in the Cesarean delivery microbiomes.
CONCLUSION: Due to their far-reaching impact on cardiometabolic and immune functions, Cesarean deliveries in high-risk patient populations should be carefully considered.
Recommended Citation
Reznik, Sandra E; Akinyemi, Ayodele J; Harary, David; Latuga, Mariam S; Fuloria, Mamta; and Charron, Maureen J, "The Effect of Cesarean Delivery on the Neonatal Gut Microbiome in an Under-Resourced Population in the Bronx, NY, USA" (2024). SKMC Student Presentations and Publications. Paper 10.
https://jdc.jefferson.edu/skmcstudentworks/10
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Language
English
Included in
Biological Phenomena, Cell Phenomena, and Immunity Commons, Congenital, Hereditary, and Neonatal Diseases and Abnormalities Commons, Health Services Research Commons
Comments
This article is the author's final published version in BMC Pediatrics, Volume 24, Issue 1, 2024, Article number 450.
The published version is available at https://doi.org/10.1186/s12887-024-04908-7.
Copyright © The Author(s) 2024