Document Type

Article

Publication Date

1-10-2020

Comments

This article is the author’s final published version in PLoS ONE, Volume 15, Issue 1, January 2020, Article number e0223397.

The published version is available at https://doi.org/10.1371/journal.pone.0223397. Copyright © Su et al.

Abstract

Tissue-resident and infiltrating immune cells are continuously exposed to molecules derived from the local cells that often come in form of secreted factors, such as cytokines. These factors are known to impact the immune cells' biology. However, very little is known about whether the tissue resident immune cells in return also affect the local environment. In this study, with the help of RNA-sequencing, we show for the first time that long-term absence of epidermal resident Langerhans cells led to significant gene expression changes in the local keratinocytes and resident dendritic epidermal T cells. Thus, immune cells might play an active role in maintaining tissue homeostasis, which should be taken in consideration at data interpretation.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

31923202

Language

English

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