Document Type
Article
Publication Date
1-10-2020
Abstract
Tissue-resident and infiltrating immune cells are continuously exposed to molecules derived from the local cells that often come in form of secreted factors, such as cytokines. These factors are known to impact the immune cells' biology. However, very little is known about whether the tissue resident immune cells in return also affect the local environment. In this study, with the help of RNA-sequencing, we show for the first time that long-term absence of epidermal resident Langerhans cells led to significant gene expression changes in the local keratinocytes and resident dendritic epidermal T cells. Thus, immune cells might play an active role in maintaining tissue homeostasis, which should be taken in consideration at data interpretation.
Recommended Citation
Su, Qingtai; Bouteau, Aurélie; Cardenas, Jacob; Uthra, Balaji; Wang, Yuanyaun; Smitherman, Cynthia; Gu, Jinghua; and Igyártó, Botond Z., "Brief communication: Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells." (2020). Department of Microbiology and Immunology Faculty Papers. Paper 114.
https://jdc.jefferson.edu/mifp/114
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
31923202
Language
English
Comments
This article is the author’s final published version in PLoS ONE, Volume 15, Issue 1, January 2020, Article number e0223397.
The published version is available at https://doi.org/10.1371/journal.pone.0223397. Copyright © Su et al.