ETD Collection for Thomas Jefferson University

Dissertations & Theses from 2017

Chand, Saswati (2017) HuR regulates Poly ADP Ribose Glycohydrolase: Implications for PARP inhibitor efficacy in pancreatic ductal adenocarcinoma cells

Gubernick, Ruth S (2017) Evaluating Family-Centered Care in Florida's Pediatric Medical Home Demonstration Project

Khasnis, Mukta Dilip (2017) Dissecting Receptor-Induced Activation of HIV-1 Env

Lytle, Andrew G (2017) Infection and Activation of Immune Cells by Rabies Virus-Based Vaccines

McNair, Christopher M (2017) Androgen Receptor and Cell Cycle Interplay in Cancer: Mechanisms and Implications

Myers, Carey Jeanne (2017) Combining Thoracic Irradiation and An Anti-PD-1 Antibody Decreases Survival Through Increased T Cell Infiltration into Cardiac and Lung Tissue

Noronha Antony, Anil (2017) The contribution of dynamic regulation of mitochondrial calcium uptake to liver pathophysiology

Oran, Amanda R (2017) Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer

Quinn, Michael (2017) Memory CD8+ T Cells Remain Functional throughout an Ongoing Persistent Infection: Implications for Antigen-Specific Immune Reconstitution and Boosting

Singh, Amrita (2017) Exosome-Mediated Transfer of Integrins Promotes Cell-Cell Communication in Prostate Cancer

Vu, Ha Linh (2017) Mutant NRAS and RAC1 signaling in melanoma

You, Jason C (2017) Epigenetic Regulation of Hippocampal Function and Cognition in Alzheimer's Disease

Zemel, Benjamin M (2017) Novel Modulation of a Dorsal Root Ganglion Potassium Channel by Calcineurin and Protein Kinase C

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Dissertations & Theses from 2016

Anderson, Warren D (2016) Multi-scale analyses of molecular network dynamics underlying neuronal excitability, neuroinflammation, and organismal homeostasis

Berger, Tamar R (2016) Structural and Functional Features of the Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy

Blomain, Erik S (2016) Silencing of GUCY2C through loss of guanylin expression is a necessary step in colorectal tumorigenesis and therapeutic target for chemoprevention

Bongiorno, Emily K (2016) Therapeutic modulation of the tumor-promoting immune type 2 microenvironment in malignant glioma by the induction of a type 1 response to attenuated rabies virus

Chen, Dongying (2016) Roles of Fibronectin and Integrin alpha5 in Pharyngeal Arch Artery Morphogenesis

Cunningham, Amy Taylor (2016) Evaluation of the Jefferson Family Medicine Associates' Diabetes Information and Support for Your Health (DISH) Program

DeCicco, Danielle (2016) Dynamic microRNA networks in the brainstem underlie the development of hypertension

Dowling, John P (2016) Necroptotic and apoptotic signaling during development and immune homeostasis

Erkes, Dan A (2016) Exploiting Murine Cytomegalovirus as an Anti-Tumor Therapy and Model for Virus-Specific Tumor Infiltrating Lymphocytes

Fastenau, John Michael (2016) Use of mediation analysis to evaluate the role of adherence on the comparative effects of atypical antipsychotics in schizophrenia

Hoang, David Timothy (2016) Therapeutic Targeting of Stat5a/b in Advanced Prostate Cancer: Inhibition of Stat5a/b Suppresses Growth of Prostate Cancer through Mechanisms Dependent and Independent of Androgen Receptor

Hullmann, Jonathan E (2016) Protein-coupled receptor kinase 5 exacerbates cardiac pathology through activation of the nuclear factor of activated T cells pathway

Jin, Yuan-Yuan (2016) Developing microRNA therapeutics for triple negative breast cancer

Klayman, Lauren M (2016) Non-canonical G protein betagamma signaling at the golgi

Ko, Ying-Hui (2016) Metabolic heterogeneity in breast cancer

Kraft, Crystal L (2016) Guanylyl cyclase C maintains integrity of intestinal stem cells through modulation of endoplasmic reticulum stress

Mogilyansky, Elena (2016) Post-transcriptional regulation of BRCA2 through interactions with miR-19a and mir-19b, two members of the miR-17/92 cluster

Monteith, Jessica A (2016) A rare DNA contact mutation in cancer confers p53 gain-of-function and alters binding specificity

Omerza, Gregory (2016) Regulation of Non-Canonical MAP Kinase Signaling

Quann, Kevin (2016) Cancer, Caveolin-1, and Non-Coding RNAs: Novel Insights into Tumor Biology

Rouleau, Lauren L (2016) The use of pharmacologic ascorbate in the treatment of hepatocellular carcinoma: mechanism of cytotoxicity and synergism with the multikinase inhibitor sorafenib

Schoepflin, Zachary (2016) Investigation of the HIF-PHD System in Nucleus Pulposus Cells of the Intervertebral Disc

Smith, Carmella Romeo (2016) HuR Contributes to the Therapeutic Resistance of Pancreatic Cancer

Tian, Xufan (2016) The functional roles of arrestin domain-containing protein 3 in regulating G protein-coupled receptor trafficking and signaling

Tio, Chong Wai (2016) Spatiotemporal Regulation of Non-Canonical MAPK Signaling

Torres, Annabel (2016) The Role of Paternally Expressed Gene 3 in Regulating Autophagy and Angiogenesis

Wen, Xinmei (2016) Identification of Pathogenic Determinants and Mechanisms of C9ORF72 linked ALS/FTD

Xiang, Bo (2016) Synergistic DNA + Adenovirus Prime-Boost Immunization in Metastatic Colorectal Cancer

Zhou, Honglei (2016) Systematic study of GPRC5A in the context of pancreatic ductal adenocarcinoma

Zhou, Yuhang (2016) MicroRNA-148a-3p and TULA-2 regulate platelet FcgammaRIIA signaling and heparininduced thrombocytopenia

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Dissertations & Theses from 2015

Brennan-Crispi, Donna (2015) DSG2 synergizes with hedgehog signaling to promote skin tumor development

Carr, Richard (2015) Biasing G protein coupled receptor signaling using pepducins

Corbett, Brian F (2015) Network dysfunction and cognitive deficits in a mouse model of Alzheimer's disease

Eaton, Gregory J. (2015) Apoptosis Signal-Regulating Kinase 1 Modulates Endochondral Bone Formation and Osteoarthritis Progression

Fried, Nathan Thomas (2015) Adenosine and Migraine

Gannon, Meghan (2015) The impact of mindfulness on the quality of parenting behaviors and reported parental stress of newly parenting mothers in medication assisted treatment for opioid dependence: Results and policy implications for federal spending

Goodwin, Jonathan F (2015) Androgen receptor and DNA damage response crosstalk: Mechanisms and impact on cancer progression

Helms, Michelle Carll (2015) Mitotic-dependent phosphorylation of leukemia-associated rhogef (LARG) by Cdk1

Jimbo, Masaya (2015) Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells

Kim, Gilbert W (2015) Targeting GUCY2C for anti-obesity pharmacotherapy Uroguanylin Replacement Opposes Obesity by Restoring Anorexigenic GUCY2C Signaling Silenced by Overnutrition-Induced Uroguanylin Deficiency

Kugel, Curtis H. (2015) Adaptive and acquired responses of mutant braf melanomas to RAF/MEK inhibitors

Magee, Michael S (2015) Guanylyl Cyclase C-Targeted CAR-T Cell Therapy for the Treatment of Metastatic Colorectal Cancer

Pumroy, Ruth (2015) Regulation of the classical nuclear import pathway through variation in the structure and function of importin alpha isoforms

Riccio, Amanda A (2015) Poly(ADP-ribose) polymerase 2 (PARP-2) mechanism of DNA damage recognition and allosteric activation

Smith, Corinne J (2015) Hematogenous maintenance of memory inflation and continuous production of mucosal resident T cells during murine cytomegalovirus (MCMV) infection

Talati, Pooja G (2015) Mechanisms of prostate cancer metastasis induced by Stat5a/b signaling

Wesolowski, Jordan (2015) Bacteria use distinct mechanisms to inhibit SNARE-mediated membrane fusion

Wong, Eric B (2015) The role of SLAM family receptors in germinal center-mediated autoimmunity

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Dissertations & Theses from 2014

Augello, Michael A (2014) Function of the Cyclin D1b oncogene in cancer progression: Mechanisms and implications

Barkhouse, Darryll (2014) Expression of interferon gamma by recombinant rabies virus strongly attenuates virus pathogenicity and enhances safety and efficacy of post-exposure treatment vectors

Black, Kathryn L (2014) Epigenetic Inheritance of Chromatin Structure during Replication and Mitosis

Correnti, Jason M (2014) Adiponectin in alcoholic liver disease and liver regeneration

Dastgheyb, Sana (2014) Staphylococcus aureus in the synovial environment: Supporting long-term survival and insensitivity to antibiotics

Goodenough, Elliot (2014) Proteomic insights into mhc class i antigen processing and presentation

Hollingsworth, Kristen (2014) The influence of the risk evaluation mitigation strategy on erythropoieses stiulating agent use in medicare patients with breast and lung cancers with chemotherapy induced anemia

Jablonski, Michael R (2014) Alterations in drug efflux at the blood-spinal cord barrier in amyotrophic lateral sclerosis

Kia, Azadeh Tehrani (2014) Characteristics of FUS-Mediated Toxicity in Amyotrophic Lateral Sclerosis

Neill, Thomas (2014) Decorin induces tumor cell mitophagy via mitostatin as the molecular basis for the suppression of angiogenesis

Retson, Tara A (2014) The interactions of alcohol, sex, and stress

Ronzone, Erik (2014) Insight into the mechanism of IncA, a type III secreted effector protein in Chlamydia trachomatis

Steblyanko, Maria A (2014) Role of integrin receptors in cytotoxic lymphocyte function

Zboray, Lori J (2014) Using cell and animal models to understand pathogenic mechanisms in spinal and bulbar muscular atrophy

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Dissertations & Theses from 2013

Balasubramaniam, Sucharitha (2013) BAF57 Deregulation Orchestrates Novel Oncogenic Signaling and Prostate Cancer Progression

Barber, Annika F (2013) Modulation of voltage-gated potassium and sodium channels by halogenated general anesthetics: Structural and biophysical insights into the mechanisms of action

Basile, Kevin Joseph (2013) Examining mechanisms of RAF inhibitor resistance in mutant BRAF melanoma

Basu, Subhasree (2013) Signaling pathways crucial in differentiation initiation and terminal differentiation during lens development

Bonne-Annee, Sandra (2013) Strongyloides stercoralis - Immunological basis for susceptibility and resistance in mice and humans

Bryant, Kelly (2013) Exploring the Role of Caveolin1 Upregulation in the Prostate

Cullimore, Melissa (2013) Establishing a role for IL-27 in the amelioration of MS and EAE

Fineberg, Jeffrey D (2013) Elucidation of auto-regulatory mechanisms in voltage-gated potassium channels

Foran, Emily (2013) Implication of a sumoylated c-terminal fragment of the astroglial glutamate transporter, EAAT2 in the non-cell autonomous mechanisms of amyotrophic lateral sclerosis pathogenesis

Goodman, Chelain Rae (2013) Induction of a therapy-resistant cytokeratin 5-positive cell population by 3-ketosteroids in luminal breast cancer

Guarino, Nicole (2013) Studies of mitochondrial dysfunction in mutant SOD1-mediated ALS and therapeutic implications

Halkidis, Konstantine (2013) Structural changes in HIV-1 Env that promote viral membrane fusion

Heine, Erin M (2013) The role and timing of aberrant polyglutamine-expanded androgen receptor proteolysis in cell models of spinal and bulbar muscular atrophy

He, Jun (2013) Repression of miR-143/145 Mediates Chromium (VI)-induced Cell Transformation, Tumor growth and Tumor angiogenesis via IGF-IR/IRS1/ERK/IL-8

Huegel, Julianne (2013) Heparan sulfate-dependent mechanisms of normal and pathological skeletogenesis

Jaremko, Kellie Marie (2013) Identifying novel targets in opioid addiction: Pre-clinical and clinical studies

Lawrence, Tessa M (2013) Innate immune recognition of rabies virus: Defining the role of the inflammasome and interferon stimulated genes

Martz, Matthew K (2013) Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in mitosis and required for the proper completion of abscission

Nikbakht, Neda (2013) Influence of BLyS on Peripheral B Lymphocyte Tolerance

Ritter, David M (2013) Kv3.4 channel function and modulation in nociceptors: Novel insights into the pathophysiology of neuropathic pain

Sanders, Jeffrey Michael (2013) Physics-Based Modeling of Engineered Biopolymers for Monitoring Gene Expression in Disease

Sato, Takahiro (2013) Prolactin-Jak-Stat Signaling Pathways in Breast Cancer

Sussman, Robyn T (2013) The epigenetic modifier Usp22 regulates the transition of embryonic stem cells from self-renewal to differentiation via transcriptional repression of SOX2

Tran, Cassie M (2013) Regulation and Function of CCN2 in the Intervertebral Disc: A Critical Anabolic Factor in Nucleus Pulposus Cells

Vagnozzi, Ronald J (2013) Cardiac Troponin I-interacting Kinase (TNNI3K/CARK) Adversely Regulates Injury, Cell Death and Oxidative Stress in the Ischemic Heart

Wanjalla, Celestine N (2013) Rabies virus-based HIV-1 vaccine vector: impact of antigen presenting cells and immunostimulatory molecules

Whinston, Elizabeth Rogers (2013) Non-Canonical MAP Kinase Signaling and Meiotic Development in Saccharomyces cerevisiae

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Dissertations & Theses from 2012

Abel, Ethan Vincent (2012) The role of FOXD3 in melanoma and response to RAF/MEK inhibitors

Conde, Angela (2012) Cyclophilin A, dynein light chain 3, and HIV-1 capsid: Defining elements of host-pathogen interactions and roles in viral replication

Danilo, Christiane (2012) Impact of Cholesterol and Lipoproteins on Breast Cancer

Dickinson, Gregory S (2012) Determining the role of Toll-like receptors in innate and adaptive immune responses to Borrelia hermsii and other antigenic targets of T cell-independent humoral immunity

Dippold, Rachael P (2012) Adaptation to ethanol dysregulates hepatic miRNA expression and alters the dynamic response of miRNAs during liver regeneration

Donaldson, Joshua Michael (2012) Improving the efficacy and side effect profile of therapeutic antibodies

Gold, Jessica I (2012) G Protein-Coupled Receptor Kinase 5 is a Novel Requirement for Maladpative Cardiac Remodeling and Heart Failure

Gomme, Emily A (2012) Harnessing the power of recombinant rabies viruses to make safer vaccines and study viral clearance from the brain

Juliana, Christine A (2012) Characterization of the NLRP3 Inflammasome: Inhibitors, Activators, and Priming

Kidd, Sarah K (2012) Protection of Dopaminergic Cells From 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/ 1-methyl-4-phenylpyridinium Toxicity by Histone Deacetylase Inhibitors

Rivadeneira, Dayana B (2012) Novel roles of the RB-pathway in human cancers: Modifying disease progression and establishing new therapeutic opportunities

Robinson, Tara M (2012) Nonclassical antigen processing and the implications for autoimmunity and infection

Schiewer, Matthew J (2012) AR, cell cycle, and DDR: Mechanisms and impact on cancer progression

Shah, Supriya (2012) Gene-environment Interactions and Novel Therapeutic Interventions in Prostate Cancer

Swope, David (2012) The Role of Plakoglobin and beta-catenin in Mechano-Electrical Coupling of the Heart

Trimmer, Casey (2012) New Insights into the Molecular and Cellular Functions of Caveolin-1 in Skin Cancer

Valentino, Michael A (2012) An Intestinal Prouroguanylin-Hypothalamic GUCY2C Axis Mediates Nutrient-Induced Satiety

Watkins, Aubrey (2012) The role of Akt isoforms in BCR-ABL induced chronic myeloid leukemia

Wixted, Josephine Fox (2012) Understanding the many facets of RET/PTC oncogene activity in thyroid carcinoma: Transformation, inflammation, and antigenicity

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Dissertations & Theses from 2011

Bourgo, Ryan J (2011) The impact of RB deficiency on hepatocyte biology and tumorigenesis

Carpenter, Richard L (2011) Arsenic-Induced Cell Transformation and Angiogenesis Requires NADPH Oxidase Isoform 2-Derived Reactive Oxygen Species

Colombo, Matthew J (2011) Analysis of B1b lymphocyte-mediated protective immunity

Comber, Joseph D (2011) MHC class II restricted processing of endogenous antigens during viral infection

Dean, Jeffry L. (2011) Therapeutic CDK4/6 inhibition in breast cancer and the importance of reestablishing cell cycle control through RB activation

Gibbons, Ahmara Vivian (2011) Epithelial-specific programming of the microenvironment by guanylyl cyclase C regulates intestinal architecture

Jensen, Deborah Anne (2011) The Effects of Expression of Thermolabile R789C and R992C Collagen II Mutants on Cell Behavior and Extracellular Matrix Structure and Function

Joshi, Amita (2011) A Comparative Analysis of Human T Cell Responses To Adenoviral Early And Late Proteins

Ketonis, Constantinos (2011) Antibiotic Modification of Native Grafts: Improving upon nature's scaffolds

Maxwell, Christina R (2011) Characterization of a rat model of chronic headache

Neely, Robert John (2011) Mechanisms of Ret/PTC 3-induced pro-inflammatory signaling

Phani, Sudarshan (2011) Gene expression studies of the VTA in an animal model of Parkinson's disease and the emergence of gremlin as a dopaminergic neuroprotective factor

Remakus, Sanda S (2011) Mechanisms of memory CD8+ T cell protection from an acute lethal viral disease

Roth, Jacquelyn Jinan (2011) Insertional Mutagenesis as a Tool for Identifying and Characterizing Novel Candidate Cancer Genes

Yersak, Jill M (2011) The 11S proteasomal activator REGgamma Impacts polyglutamine-expanded androgen receptor aggregation and toxicity in cell models of spinal and bulbar muscular atrophy

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Dissertations & Theses from 2010

Ahmed, Noreen T (2010) Regulation of middle meiotic gene expression by the Sum1 repressor in Saccharomyces cerevisiae

Brown, Timothy B (2010) In vivo analysis of cell-autonomous versus non-cell-autonomous contributions to neuronal dysfunction in disorders of the basal ganglia

Castellini, Meryl A (2010) DNA mismatch repair in Plasmodium falciparum: A potential mechanism for accelerated drug resistance

Coffey, Francis J (2010) Antigen-Driven B Cell Differentiation and Mechanisms of Peripheral Tolerance During the T Cell-Dependent Immune Response

Faul, Elizabeth J (2010) A comprehensive analysis of interferon-beta's role in shaping the immunogenicity and pathogenicity of rabies virus: Development of a novel vaccine vector

Lin, Jieru Egeria (2010) GUCY2C Opposes Premalignant Transformation in Intestine by Regulating PTEN-PI3K/AKT Signaling

McIlhenny, Stephen Edward (2010) The use of adult adipose-derived stem cells in the creation of a tissue engineered vascular bypass graft

Metzler-Wilson, Kristen (2010) S100A1 competes with calmodulin for calmodulin binding proteins, CaV1.2 and SK2 channels

Michal, Allison M (2010) Novel roles of GRKs and arrestins in cell cycle regulation and breast cancer

Pavlides, Stephanos (2010) Caveolin-1 in Human Disease: The Roles of Caveolin-1 in Cancer and Atherosclerosis

Popov, Vladimir M (2010) The Cell Fate Determination Factor DACH1 In Breast Cancer

Rosenberg, Stephen M (2010) Analysis of the function of FADD in hematopoietic stem cells, lineage development and hematopoietic function

Ryder, Amy (2010) Stat5 transcription factors in human breast cancer: Prognosis, tamoxifen response prediction and gene regulation

Shin, Marcus (2010) Regulation of meiotic development in Saccharomyces cerevisiae by the meiosis-specific Ime2 protein kinase

Siglin, Amanda E (2010) Biophysical and in vivo characterization of the dynein-dynactin interaction; implications for multiple modes of regulation

Silver, Hannah (2010) Multiple Genome Stability Roles for SIZ-dependent Sumoylation in Saccharomyces cerevisiae

Smolock, Amanda R (2010) The roles of calpain and protein kinase C in type 1 diabetic vascular dysfunction

Testa, James S. (2010) Elucidation of MHC class II-restricted antigen processing pathways using influenza virus epitopes

Turner, Kevin R (2010) Type I collagen-integrin interactions in angiogenesis

Waldron, Todd J (2010) A role for Myb in BCR-ABLp190-induced leukemogenesis: Regulation of Arf suppression through transcriptional activation of BMI1

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Dissertations & Theses from 2009

Ambrose-Lanci, Lisa M (2009) Influence of opioid and estrogen systems on cocaine withdrawal in females

Banini, Bubu Ama (2009) Upregulation of fetal hemoglobin in adult-derived erythroid progenitors

Gallagher-Colombo, Shannon (2009) Multifunctional roles of lactate transporters in wound healing and metastasis

Heo, Soyoung (2009) Exploring p53 protein -protein interactions as targets for chemotherapy

Hu, Rong (2009) F -box proteins and co-factors of SCF E3 ubiquitin ligases in melanoma

Kahle, Kristen M (2009) Kinetics of HIV-1 Fusion Inhibition: Implications for Viral Resistance and the Design of Improved Fusion Inhibitors

Kern, Ronald C (2009) Novel insights into arrestin mediated receptor trafficking

Matullo, Christine (2009) Double trouble: How simultaneous immune challenges can result in CNS disease

Moore, Michael (2009) Regulation of the transcriptional repressor Sum1 by the meiosis-specific kinase Ime2 in S. cerevisiae

O'Connell, Amy E (2009) Neutrophils and macrophages in the immune response to parasitic helminths

Shuda, Kristy (2009) Molecular basis of aneuploidy: Functions of the aurora kinases, Rad51c, and CREB binding protein in female meiosis

Woulfe, Kathleen Camille (2009) Deletion of GSK-3beta in vivo: Revealing the role of this signal integrator in cardiomyocyte hypertrophy and proliferation

Zahm, Adam M (2009) Induction of the osteocytic phenotype: The influence of oxygen on bone cell maturation and survival

Zoeller, Jason Joseph (2009) Perlecan coordinates developmental angiogenesis

Zuzga, David S (2009) Guanylyl cyclase C remodels metastatic architecture through vasodilator-stimulated phosphoprotein

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Dissertations & Theses from 2008

Appel, Michael Jay (2008) Approaches toward the investigation of T cell specificities and antigenic determinants in an MHC-matched mouse GVHD model

Beal, Allison M (2008) T cell-mediated cytotoxicity: Understanding the mechanism of effective delivery of a poison pill

Busillo, John M. (2008) Characterizing the Dynamics and Functional Role of Site-Specific Phosphorylation of G Protein-Coupled Receptors

Castorino, John Joseph (2008) Functional dissection of the c-myc mRNA coding region instability determinant

Champagne, Kelly (2008) Structure, folding and engineering of 5-helix, a designed HIV-1 entry inhibitor

Chen, Yingying (2008) Prostaglandin D2 differentially regulates functions of human NK cell subsets through distinct receptors

Crouthamel, Marykate (2008) Role of a polybasic motif in plasma membrane targeting and signaling of G protein alpha subunits

DeGeorge, Brent Robert (2008) Investigating the role of the adenylyl cyclase inhibitory G protein alpha subunit (Galphai2) in dysfunctional myocardium

Dougherty, Kevin Joseph (2008) A novel integral voltage sensor-interacting protein: Shedding light on the gating mechanisms of somatodendritic Kv channels

Johnston, Danika M (2008) A new mechanism for transcriptional regulation by nuclear hormone receptors during Drosophila development

Kerr, Bethany Amber (2008) The roles of the Rho GTPase protein Rac-1 in cell morphology and function during chondrocyte maturation

Lazarus, Michelle Denise (2008) A New Model For Hemoglobin ingestion and transport by the Human Intraerythrocytic Malaria Parasite, Plasmodium falciparum

Leonard, Michelle (2008) N-cadherin junction formation drives lens fiber cell differentiation and morphogenesis

Martini, Jeffrey S (2008) Uncovering G protein-coupled receptor kinase-5 as a novel histone deacetylase kinase

Pulmanausahakul, Rojjanaporn (2008) Pathogenicity determinants of rabies virus and their function in the pathogenesis of rabies

Ratanadilok Na Phuket, Thanawath (2008) Expression of Kv4 channels in dorsal root ganglion neurons: Major determinants of the A-type potassium current

Riley, Kristen Marie (2008) Regulation of apoptosis by p53 and the ecdysone receptor co-activator TRR in Drosophila

Roy, Anirban (2008) Immune evasion by silver-haired bat rabies virus and implications for treatment

Rudoy, Carla Ann (2008) Targeting Adrenergic Receptors in the Treatment of Cocaine Withdrawal-Related Anxiety

Waselus, Maria (2008) Regulation of the dorsal raphe nucleus serotonin system by the stress related peptide corticotropin-releasing factor

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Dissertations & Theses from 2007

Cesarone, Gregory V (2007) Insulin receptor substrate 1, a novel oncogene target in breast cancer

Grabocka, Elda (2007) RGS-RhoGEFs: Interactions with G proteins and identification of novel subcellular locations and function

Pao, Christina S (2007) Mechanism of G protein-coupled receptor kinase binding and activation by G protein-coupled receptors

Phares, Timothy W (2007) Mechanism of immune clearance of virus from the central nervous system in the absence of disease

Pratt, Craig Herbert (2007) Transcriptional regulatory network analysis of retinal pigment epithelial cells during epithelial-mesenchymal transformations

Pufnock, Jeffrey S (2007) The immunological effects of a thyroid oncogene on tumor progression

Schug, Zachary Tiberius (2007) Inter-domain Associations and Gating of the Inositol 1,4,5-trisphosphate Receptor

Tan, Gene S (2007) The Dynein Light Chain 8 Binding Motif of Rabies Virus Phosphoprotein Promotes Efficient Viral Transcription

Terkhorn, Shawn Patrick (2007) Hypoxia inducible factor and prolyl hydroxylase regulation of growth plate function

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Dissertations & Theses from 2006

Boland, Genevieve Marie (2006) Molecular characterization of adult human mesenchymal stem cell differentiation: The role of Wnt signaling

Bucaro, Michael A (2006) Bone cell survival in microgravity: The effects of vector -averaged gravity on the osteoblast

Casta, Louis John (2006) Function of the structure-specific metallonuclease flap endonuclease-1 in the Plasmodium falciparum DNA base excision repair pathway

Charbonneau, Nicole Rene (2006) Expression and interactions of hMLH3 in DNA repair

Elliott, Aaron Matthew (2006) The function of CREB -binding protein in germline development

Evans, Stella R (2006) The CLCA family of calcium-activated chloride channels and roles in the eye

Franke, Aaron S (2006) Myosin crossbridge kinetics and the mechanism of catch: Single turnover of myosin-bound ADP in catch muscle

McKenna, Philip M (2006) Characterization and immunogenicity of recombinant rhabdoviral vaccine vectors expressing HIV-1 and SIV envelope proteins

Milano, Shawn K (2006) Arrestin-2: Structure and function

Palmitessa, Aimee (2006) In vivo characterization of C. elegans arrestin

Planey, Sonia Lobo (2006) Steroid receptors and lymphoma cell apoptosis

Plesa, Gabriela (2006) The effect of antigen dose and viral cytopathicity on CD8 T cell responses

Schindler, Karen (2006) Regulation of the meiosis-specific Ime2 protein kinase in Saccharomyces cerevisiae

Smith, Mary Ellen (2006) Rabies virus as an immunostimulatory carrier molecule for vaccination against anthrax

Steger, H. Kirby (2006) Kinetic restriction of HIV-1 entry inhibition

Weber, Gregory F (2006) Survival and apoptotic-related signaling pathways regulate lens cell differentiation

Wolfe, Henry R (2006) Design, synthesis and analysis of ligands for guanylyl cyclase C

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Dissertations & Theses from 2005

Anderson, David William (2005) The interactions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment and age with ganglioside therapy on the nigrostriatal dopamine system

Bungard, David (2005) Molecular-genetic analysis of the role of the RSC chromatin remodeling complex during sporulation in Saccharomyces cerevisiae

Datto, Jeffrey P (2005) Inhibiting glutamate excitotoxicity in spinal cord injury

Drakas, Robert A (2005) Identification of proteins associated with IRS-1using a newly developed tandem affinity purification technique

Duffy, Kevin T (2005) Perturbation of oncogenic orthologs in zebrafish

Karpinich, Natalie Olena (2005) The functions of the proteins Bax and Bid in apoptosis

Kerepesi, Laura A (2005) Innate and adaptive immune-mediated resistance to larval Strongyloides stercoralis

Lubbe, Wilhelm Johannes (2005) Guanylyl cyclase C activity inhibits colorectal carcinoma cell metastatic seeding of the lung by a matrix metalloproteinase-9-dependent mechanism

O'Brien, Christopher Joseph (2005) Characterization of a mouse model of spinal and bulbar muscular atrophy and biochemical analysis of neuronal intranuclear inclusions

Owens, Nafeesa Hadiyah Hunt (2005) Nuclear and mitochondrial regulation of cellular differentiation: Roles of serum response factor and tumor suppressor p53

Simsek, Ender (2005) The role of alpha-glucosidase mediated N-linked glycan processing in the secretion and degradation of hepatitis B virus envelope proteins

Smith, Sheryl T (2005) Function of the TAC1 histone modification complex, in Drosophila

Takida, Satoshi (2005) Lipid modifications and membrane trafficking of G protein alphabetagamma subunits and beta5RGS7

Zook, Matthew B (2005) Immunological implications of recoding: Significance and utility of the CD8+ T cell response to epitopes produced as a result of ribosomal frameshifting

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Dissertations & Theses from 2004

Abdollahi, Touraj (2004) The effects of TRAIL and interleukin-8 on survival in ovarian cancer

Coleman, Cynthia Marie (2004) Role of growth/differentiation factor 5 in embryonic limb cartilage development

Crumm, Sara E (2004) Energy metabolism in the regenerating rat liver following partial hepatectomy: Rapid changes in adenine nucleotides and AMP -activated protein kinase signaling

Day, Peter William (2004) Characterization of the interaction between Galphaq and GRK2

DiGuglielmo, Matthew DiPasquantonio (2004) Tissue-specific transcriptional regulation of guanylyl cyclase C expression: Relation to intestinal epithelial cell dynamics

Goodrich, Adrienne J (2004) Construction of a novel self-inactivating gene activating vector: Splicing and non-encapsidation of vector RNA

Guo, Yin (2004) Studies on the role of mitochondria in the regulation of cell death

Jones, Stephen Charles (2004) The immunobiology of graft-versus-host disease across a minor histocompatibility antigen barrier

Li, Wan-Ju (2004) A biodegradable, three-dimensional nanofibrous scaffold for cartilage tissue engineering: Fabrication, characterization, and applications

Loza, Matthew J (2004) The common functional maturation pathway of natural killer and T cells

Martin, Eric Santos (2004) Genetic and molecular characterization of the BCSC-1 candidate tumor suppressor gene

Ottey, Michelle A (2004) The FHIT tumor suppressor gene: A functional role in apoptosis and cell cycle response

Razmara, Marjaneh (2004) Ice and card containing proteins: Dancing between life and death

Ruiz-Stewart, Inez (2004) Adenine nucleotide regulation of soluble guanylyl cyclase: Coupling nitric oxide signaling to cell metabolism

Stalker, Timothy J (2004) A novel role for the calcium-dependent protease calpain in the vascular dysfunction of hyperglycemia and diabetes

Sweeney, Shawn M (2004) Mechanisms of collagen I-endothelial cell interactions during the tube-formation phase of angiogenesis

Tewari, Mona K (2004) Processing of exogenous and endogenous influenza virus glycoproteins for MHC class II restricted presentation

Tomkowicz, Brian E (2004) Transformation by the human herpesvirus-8 oncoprotein, Kaposin

Tungaturthi, Parithosh K (2004) HIV-1 Vpr: Implications in AIDS Pathogenesis

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Dissertations & Theses from 2003

Boehning, Darren (2003) Structure-function relationships in inositol 1,4,5-trisphosphate receptor Ca2+ channels

Booth, Gregory M (2003) Acute hyperglycemia stimulates leukocyte-endothelium interactions in vivo: Role of NO and p-selectin

Caterson, Edward J (2003) Human bone marrow-derived progenitor cells for cartilage tissue engineering

Cheung, Mitchell (2003) The identification and characterization of candidate genes for Tourette and bipolar disorders

Cifarelli, Christopher Paul (2003) Characterization and functional analysis of N-cadherin ectodomain shedding during retinal development

Desai, Anup M (2003) Glutamate receptors in the striatum and recovery from experimental Parkinsonism

Emlet, David R (2003) Novel functions of individual epidermal growth factor receptor autophosphorylation sites in receptor regulation and signal transduction

Kim, You-Me (2003) Regulation of Arrestins in G Protein-Coupled Receptor Signal Transduction Pathways

Schiffman, Jonathan S (2003) Expression and function of cadherins in normal and pathological retina

Silverman, Karen A (2003) Identification and analysis of colorectal cancer susceptibility genes in the Apcmin mouse model

Tili, Esmerina (2003) The role of Akt in T cell development and function

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Dissertations & Theses from 2002

Alexander, Peter G (2002) The role of paraxis in somitogenesis and carbon monoxide-induced axial skeletal teratogenesis

Beck, Edward J (2002) Modulation of A-type potassium channel inactivation gating: Structural switches and novel subunits

Foley, Heather Dawn (2002) Rhabdovirus-based vectors as an HIV-1 vaccine

Kazerounian, Shideh (2002) Periplakin, an autoantigen in paraneoplastic pemphigus and pemphigus foliaceus, an intermediate filament-binding protein, and a component of the insoluble structures of epidermal keratinocytes

Kazerounian, Shiva (2002) Integration of cyclic GMP and calcium signaling

Krisak, Lisa Ann (2002) Analysis of the role of cadherins in retinoblastoma tumor cell adhesion and growth

McGettigan, James P. (2002) Cellular immune responses against HIV-1 proteins expressed by a highly attenuated rabies-virus-based vaccine vector

Naso, Michael Francis (2002) Transcriptional regulation and developmental expression of collagen type VII in keratinocytes

Nesti, Leon J (2002) Identification and functional characterization of a novel TGF-beta1 activated calcium signaling pathway in human osteoblasts

Patterson, Anthony Edward (2002) Graft-versus-myeloid leukemia responses in murine bone marrow transplantations

Schaber, Michael (2002) The dynamic expression and activation of Smk1 during sporulation in Saccharomyces cerevisiae requires a Cdc28-independent activity of Cak1

Stubbs, Matthew (2002) The E2F1 Transcription Factor, the ZF87 Transcription Factor, and the Control of Cell Cycle Transit

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Dissertations & Theses from 2001

Cortese, Stacey Christine (2001) The role of the epidermal growth factor receptor in the growth and differentiation of the retinal pigment epithelium

DeLise, Anthony Michael (2001) N-cadherin mediated cell -cell interactions during cellular condensation and chondrogenesis in embryonic chick limb development

Fei, Peiwen (2001) Role of WIP1 in WTP53-induced G2/M arrest

McAleer, Mary Frances (2001) The role of metallothionein in apoptosis of human trophoblastic cells

Park, Jason (2001) Tissue-specific expression of guanylyl cyclase C is regulated by the caudal-related homeodomain protein CDX2

Walker, Janice Lynn (2001) Examination of the regulatory roles of alpha6 integrin in lens cell differentiation

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Dissertations & Theses from 2000

Ansari, Sameer Ahmad (2000) HIV-1 TAT-mediated transcription through TAR RNA: Role of YB-1 and cell cycle regulated NF-kB in glial cells

Halak, Brian Keith (2000) The role of interleukin-10 in immune escape by a murine transitional cell carcinoma

Woodward, Wendy Ann (2000) Regulation of embryonic limb mesenchymal chondrogenesis: Cell adhesion and Wnt signaling

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Dissertations & Theses from 1999

Antonyak, Marc A (1999) Elevated JNK activation contributes to transformation and resistance to apoptosis in an in vitro model of transformation and in primary brain tumors

Carman, Christopher Vincent (1999) Characterization of novel G protein -coupled receptor kinase interactions and functions

Chepenik, Lara Gayle (1999) Mechanisms by which the cellular protein, Pur-alpha, and HIV-1 Tat mediate transcription of viral genes

Choi, Eugene Jinkyu (1999) Adhesion molecules mediate the ability of human polymorphonuclear neutrophils to proteolytically penetrate a basement membrane-like barrier

Edling, Andrea Elizabeth (1999) The effect of small molecular inhibitors of CD4 on experimental allergic encephalomyelitis

Goodman, Oscar Baylin (1999) Clathrin lattice assembly and adaptor recruitment in receptor -mediated endocytosis

Gradia, Scott David (1999) Signaling human mismatch repair by the formation of a hMSH2 -hMSH6 sliding DNA clamp

Haltiwanger, Brett Maher (1999) Characterization of a DNA base excision repair pathway in the malaria parasite Plasmodium falciparum: From RIPs to repair

Jiang, An (1999) The construction and applications of cell -type -specific retroviral gene -transfer vectors derived from spleen necrosis virus: From in vitro to in vivo

Kang, Jason Jongho (1999) Apoptotic caspase activation in the yeast Saccharomyces cerevisiae

Kouba, David Jonathan (1999) Transcriptional regulation of the human alpha2(I) collagen (COL1A2) gene by tumor necrosis factor-alpha and interferon -gamma

Krupnick, Jason Garrett (1999) Molecular mechanisms of regulation of G protein -coupled receptor signaling by arrestins

Kundu, Mondira (1999) Mutual interactions between HIV-1 and the host cell cycle: Implications for the neuropathogenesis of ADC

Neary, Catherine Louise (1999) The role of the cytoskeleton in cell death

Reed, Charles Christopher (1999) Ligand recognition in mutant proteins

Safak, Mahmut (1999) A 23 -base-pair sequence element and its role in JC virus gene transcription

Serio, Dawn Marie (1999) Novel HIV-1 therapeutic agents based on virion -targeted viral proteins

Shah, Asit K (1999) Effects of transforming growth factor beta-1 and bone morphogenetic protein-2 on osteoblasts at the bone-biomaterial interface

Steelman, Scott (1999) Members of the MEIS1 homeoprotein family are involved in binding the laminin B1 enhancer

Ukropec, Jon Alec (1999) Fluid shear stress-induced reorganization of adherens junctions in human endothelial cells

Wherry, Edward John (1999) The role of tripeptidyl peptidase II in MHC class I-restricted antigen processing and the effect of epitope density of CD8+ T cell priming

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Dissertations & Theses from 1998

Bach, Tami Lee (1998) Identification of a novel interaction between the N-terminal domain of fibrin and VE -cadherin: Its role in angiogenesis

Bennett, Ian Moore (1998) Natural killer cell differentiation

Chianese-Bullock, Kimberly A (1998) Two MHC class II-restricted epitopes are processed in distinct endocytic compartments as a result of the acid-induced structural changes in a viral glycoprotein

Garcia, Ramon John (1998) Activation mechanisms of phospholipase D; an ethanol -metabolizing enzyme

Handler, Melissa (1998) Expression of the heparan sulfate proteoglycan perlecan during murine embryogenesis and tumorigenesis

Hershberger, Marcia E (1998) Placental 57 kDa Ca2+ binding protein: Regulation of expression and function in trophoblast differentiation and calcium homeostasis

Howard-Claudio, Candace Michelle (1998) The effects of pRb2/p130 on tumorigenesis

Jerng, Henry Hungtao (1998) Mechanism of inactivation in brain potassium channels: Molecular gates and shutters

Lawe, Deirdre C (1998) The molecular and cellular characterization of Nck, an SH2/SH3 adaptor protein, in signal transduction

Lucas, Kimberly Anne (1998) Pathways of lipopolysaccharide-induced prostaglandin E$\sb2$ production in human microvascular endothelial cells

MacLachlan, Timothy Kenneth (1998) Characterization of the PITALRE /CDK9 and PISSLRE cdc2-related kinases

Mendrola, Jeannine M (1998) Characterization of the receptor protein tyrosine phosphatase gamma gene product

Nossuli, Tareck Omar (1998) Effects of peroxynitrite, a reactive oxygen species, in myocardial reperfusion injury

Phiel, Christopher Jon (1998) Elucidation of the mechanism and pathways promoting intestinal smooth muscle cell differentiation

Rencic, Adrienne (1998) Molecular models for studying CNS associated tumors and dysmyelination

Taddeo, Frank J (1998) A comparative study of the modes of activation of protein kinase C

Trelka, Darin Patrick (1998) The ins and outs of macromolecular transport in malaria-infected erythrocytes

Veneziale, Robert William (1998) Organization of $\beta\sb1$ integrin and N -cadherin mediated adhesion complexes during lens cell differentiation

Wagner, Marisa (1998) Genetic analysis of a mitogen -activated protein kinase required for spore morphogenesis in Saccharomyces cerevisiae

Wubah, Judith Afedua (1998) A model for p53 gene -teratogen interaction in early mouse embryos

Xu, Shi-Qiong (1998) Purification and identification of a growth factor that sustains the growth of fibroblasts null for the IGF-I receptor

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Dissertations & Theses from 1997

Brigandi, Richard A (1997) Antibody- and complement-mediated immunity to infective and autoinfective third stage larvae of {\it Strongyloides stercoralis\/}

Chen, Paul Chih-Hsueh (1997) Structural and functional analysis of the two human tumor necrosis factor receptors

Choksi, Swati (1997) Structure-based designed CD8 peptide analogs inhibit both {\it in vitro\/} and {\it in vivo\/} CD8$\sp{+}$ T cell responses

Denker, Andrew Evan (1997) Chondrogenic activity of transforming growth factor-$\beta$1 and bone morphogenetic protein-2 on multipotential mesenchymal cells

Deshmane, Sujata Praful (1997) Mechanisms underlying receptor-effector coupling of guanylyl cyclase C

Engelhard, Andrew G (1997) The role of the B -myb gene in differentiation

Evanko, Daniel Stephen (1997) Characterization of the human beta$\sb1$-adrenergic receptor gene and its transcriptional regulation

Finnegan, Alysia Argeson (1997) Molecular characterization of the hypervariable yellow($A\sp{hvy}$) allele at the murine agouti locus and investigation of factors influencing phenotypic variability

Gersh, Meryl Hope (1997) The phenotypic mapping of the cat-like cry observed in the cri-du-chat syndrome and molecular characterization of the proposed critical region

Haas, Andrew Robert (1997) Chondrogenic induction by bone morphogenetic protein -2: Involvement of N-cadherin-associated functions

Hall, James Perry (1997) Investigations into mitogen-activated protein (MAP) kinase signal transduction pathways in {\it Saccharomyces cerevisiae\/}

Jena, Nilamani (1997) Structure-function analysis of BCL2$\alpha$ and characterization of BMP-7 null mice

Koblish, Michael (1997) Development of a murine model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) susceptibility for quantitative trait locus mapping

Koch, Ute (1997) Inhibition of bone marrow and skin graft rejection by a synthetic CD4-CDR3 peptide analog in murine transplantation models

Limardo, Maria Isabel (1997) Molecular genetics of the 180-kDa bullous pemphigoid antigen (BPAG2/COL17A1), a transmembrane protein of the basement membrane zone of the stratifying squamous epithelia

Loudon, Robert Peter (1997) Expression and characterization of the G protein-coupled receptor kinase GRK6

MacPhee-Pellini, Melina (1997) Secretory phospholipase A2: A candidate for the {\it Mom1\/} locus, a major modifier of {it Apc\/}$\sp{Min}$-induced intestinal neoplasia

Marini, Joseph C (1997) A CD4-CDER3 peptide analog inhibits both primary and secondary CD4T cell responses in experimental allergic encephalomyelitis

Martinez, Robert Vincent P (1997) Cloning and characterization of the {\it DR -nm23\/} gene and its associated product, a novel member of the {\it nm23\/} gene family

Moskow, John Joseph (1997) Identification and characterization of {\it Meis1}, a common site of viral integration involved in murine myeloid leukemia

Parkinson, Scott James (1997) Adenine nucleotide regulation of receptor guanylyl cyclases: Application to interrupt {\it Escherichia coli\/} heat -stable entertoxin-dependent signalling mediating secretory diarrhea

Raj, Ganesh Venkataram (1997) The molecular pathogenesis of demyelination and CNS tumors induced by the neurotropic papovavirus, JCV

Sang, Nianli (1997) Characterization of the transcriptional regulatory functions of the transforming region of the adenovirus E1A oncoprotein

Sell, Leslie Jean (1997) The molecular characterization of chromosome 18 abnormalities associated with specific phenotypes

Slavinsky, Christopher W (1997) Characterization and analysis of the murine cartilage oligomeric matrix protein (COMP) gene

Strathdee, Gordon Ronald (1997) Molecular and cytogenetic analysis of the 18q -syndrome

Thiyagarajan, Manimekalai Mohanasundari (1997) Characterization of {\it Ustilago maydis\/} topoisomerase I: Purification, cloning, biochemical and kinetic analysis

Victoria, Teresa (1997) Molecular characterization of the canine model for globoid cell leukodystrophy (Krabbe disease) and study of the effects of human polymorphisms on the activity of murine galactocerebrosidase

Yuan, Constance Miao-Leng (1997) The human COL1A1/COL2A1 chimeric gene in transgenic mice: Analysis of the mRNA expression and the apparent inhibition of translation from the construct

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Dissertations & Theses from 1996

Basu, Soumitra (1996) Cellular pharmacology of oligonucleotide analogs

Bullock, Timothy Nicholas James (1996) MHC class I-restricted cryptic epitopes: Their production and immunogenicity

Chen, Nancie Nien-Tsyr (1996) Identification and characterization of cellular proteins regulating transcription of human neurotropic virus, JCV

Connelly, Patrick Raymond (1996) Retinoid signaling and cell cycle regulation during murine palate development

Earley, James Joseph (1996) High-throughput DNA sequence analysis for thr investigation of genetic diseases by the candidate gene approach

Hazel, Betsy Ann (1996) Hydroquinone, a major bone marrow metabolite of benzene, induces granulopoiesis in a mouse model: Possible role in benzene-induced acute myelogenous leukemia

Hill, Jason Eric (1996) Partial analysis of sequences expressed by human osteoblasts {\it in vitro\/} using differential display-PCR (DD-PCR)

Megonigal, Maureen D (1996) Mutant DNA topoisomerase I-induced lethality in {\it Saccharomyces cerevisiae\/}

Mylet, Johanna C (1996) The role of RAD1 in repeat-mediated double strand break repair of variable number tandem repeats (VNTRs) in {\it Saccharomyces cerevisiae\/}

Reardon, Brian James (1996) The molecular and genetic characterization of the {\it DAT1\/} gene product of {\it Saccharomyces cerevisiae\/}

Rock, Matthew James (1996) Molecular genetic analysis of N-cadherin structure and function

Suri, Dorothy E (1996) Modulation of expression of human urokinase-type plasminogen activator by HTLV-1 protein tax, spermine and glipizide

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Dissertations & Theses from 1994

Liddell, Rebecca Ann (1994) Analysis of isoactin gene expression during normal and abnormal gastrointestinal smooth muscle development

Pastorino, John Gaetano (1994) Mitochondrial deenergization and the subsequent formation of the permeability transition are critical to hypoxic cell killing

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Dissertations & Theses from 1992

Dorer, Douglas R (1992) A genetic and molecular analysis of the {\it Triplo-lethal\/} locus of {\it Drosophila melanogaster\/}

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Dissertations & Theses from 1990

Hathaway, Charles Briggs (1990) Sources and control of release of plasma catecholamines in the American eel, {\it Anguilla rostrata\/} (Teleostei)

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Dissertations & Theses from 1984



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Dissertations & Theses from 1983