Document Type
Article
Publication Date
March 2006
Abstract
Ribosome recycling, the last step in translation, is now accepted as an essential process for prokaryotes. In 2005, three laboratories showed that ribosome-recycling factor (RRF) and elongation factor G (EF-G) cause dissociation of ribosomes into subunits, solving the long-standing problem of how this essential step of translation occurs. However, there remains ongoing controversy regarding the other actions of RRF and EF-G during ribosome recycling. We propose that the available data are consistent with the notion that RRF and EF-G not only split ribosomes into subunits but also participate directly in the release of deacylated tRNA and mRNA for the next round of translation.
Recommended Citation
Hirokawa, Go; Demeshkina, Natalia; Iwakura, Nobuhiro; Kaji, Hideko; and Kaji, Akira, "The ribosome-recycling step: consensus or controversy?" (2006). Department of Biochemistry and Molecular Biology Faculty Papers. Paper 6.
https://jdc.jefferson.edu/bmpfp/6
Comments
This article has been peer-reviewed. It is the authors' final version prior to publication in Trends in Biochemical Sciences 31(3):143-149, March, 2006. The published version is available at http://dx.doi.org/10.1016/j.tibs.2006.01.007. Copyright is retained by Elsevier, Inc.