Document Type
Article
Publication Date
8-1-2015
Abstract
Human cells respond to DNA damage with an acute and transient burst in production of poly(ADP-ribose), a posttranslational modification that expedites damage repair and plays a pivotal role in cell fate decisions. Poly(ADP-ribose) polymerases (PARPs) and glycohydrolase (PARG) are the key set of enzymes that orchestrate the rise and fall in cellular levels of poly(ADP-ribose). In this perspective, we focus on recent structural and mechanistic insights into the enzymes involved in poly(ADP-ribose) production and turnover, and we highlight important questions that remain to be answered.
Recommended Citation
Pascal, John M. and Ellenberger, Tom, "The rise and fall of poly(ADP-ribose): An enzymatic perspective." (2015). Department of Biochemistry and Molecular Biology Faculty Papers. Paper 105.
https://jdc.jefferson.edu/bmpfp/105
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
PubMed ID
25963443
Comments
This article has been peer reviewed. It is the authors' final version prior to publication in DNA Repair
Volume 32, August 2015, Pages 10-16.
The published version is available at DOI: 10.1016/j.dnarep.2015.04.008. Copyright © Elsevier