Fundus autofluorescence and optical coherence tomography findings in choroidal melanocytic lesions.
Document Type
Article
Publication Date
7-1-2010
Abstract
PURPOSE: To establish the characteristics of secondary retinal and retinal pigment epithelial (RPE) changes associated with the presence of choroidal melanoma and choroidal nevus as documented by optical coherence tomography (OCT) and fundus autofluorescence (FAF).
MATERIALS AND METHODS: PubMed review of major English publications examining the correlation between clinical characteristics of choroidal melanoma and nevus with OCT and FAF findings.
RESULTS: The intrinsic properties of choroidal melanoma, as well as overlying RPE changes, drusen, and lipofuscin are best characterized by FAF, while OCT is more sensitive for the identification of subretinal and intraretinal fluid as well as atrophy, degeneration, and photoreceptor loss in the neurosensory retina.
CONCLUSIONS: Secondary retinal changes associated with choroidal melanocytic lesions can be documented by OCT and FAF. OCT-evident changes are observed more often with choroidal melanoma than choroidal nevus. OCT is better suited to identify the overlying retinal detachment and edema, even before these findings are clinically apparent. FAF is most useful in documenting the presence of lipofuscin, a finding that represents one of the important criteria in differentiating small choroidal melanoma from benign choroidal nevus.
Recommended Citation
Materin, Miguel A; Raducu, Raluca; Bianciotto, Carlos; and Shields, Carol L, "Fundus autofluorescence and optical coherence tomography findings in choroidal melanocytic lesions." (2010). Wills Eye Hospital Papers. Paper 37.
https://jdc.jefferson.edu/willsfp/37
PubMed ID
20844674
Comments
This article has been peer reviewed. It was published in: Middle East African journal of ophthalmology.
Volume 17, Issue 3, July 2010, Pages 201-6.
The published version is available at DOI: 10.4103/0974-9233.65489. Copyright © MedKnow.