Document Type

Report

Publication Date

2-12-2026

Comments

This article is the author’s final published version in American Journal of Ophthalmology Case Reports, Volume 42, 2026, Article number 102544.

The published version is available at https://doi.org/10.1016/j.ajoc.2026.102544. Copyright © 2026 The Authors.

 

Abstract

PURPOSE: Idiopathic retinitis, vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome is typically diagnosed after characteristic intravenous fluorescein angiography (IVFA) findings develop. This case demonstrates that identifying a green intravascular and perivascular signal on multicolor fundus imaging may be a potential noninvasive imaging sign for ischemic retinal vasculitis in IRVAN.

OBSERVATIONS: A 55-year-old female presented with bilateral optic disc edema and subtle peripapillary retinal vascular changes. Multicolor imaging showed a distinct green intravascular and perivascular signal before undergoing IVFA evaluation. Subsequent IVFA ultimately showed peripheral capillary nonperfusion, microaneurysms, and leakage consistent with IRVAN.

CONCLUSIONS AND IMPORTANCE: This case demonstrates the potential utility of multicolor imaging for detecting subtle vascular abnormalities that are not apparent on clinical examination or on traditional color fundus photography. Recognition of this green vessel signal may serve as an imaging sign of vascular wall changes, prompting consideration of IRVAN and guiding timely further angiographic evaluation in patients presenting with atypical optic disc edema or suspected retinal vasculitis.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

41732750

Language

English

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