Document Type

Report

Publication Date

8-20-2025

Comments

This article is the author’s final published version in American Journal of Ophthalmology Case Reports, Volume 39, 2025, Article number 10240.

The published version is available at https://doi.org/10.1016/j.ajoc.2025.102409. Copyright © 2025 Published by Elsevier Inc.

Abstract

PURPOSE: Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) has recently been distinguished as its own disease entity separate from other demyelinating diseases. This case report highlights the possible association of orbital trauma with the development of MOG antibody (MOG-IgG) optic neuritis.

OBSERVATIONS: A 31-year-old male with no significant ocular history presented with blurry vision in the right eye four weeks after a motorcycle crash. Right eye examination was notable for a significant decrease in visual acuity with a relative afferent pupillary defect and circumferential disc elevation on fundoscopy. An extensive workup, including imaging and serology, revealed optic neuritis with a positive MOG-IgG antibody titer. The patient was treated with intravenous steroids followed by an oral taper, with near-complete resolution of his symptoms.

CONCLUSIONS AND IMPORTANCE: MOG antibody-related optic neuritis should be considered in patients presenting with painful vision loss after trauma, as early recognition and treatment can lead to favorable outcomes.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

PubMed ID

40933085

Language

English

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