Document Type

Article

Publication Date

6-5-2025

Comments

This article is the author's final published version in Journal of Current Ophthalmology, Volume 36, Issue 3, 2025, 284 - 290.

The published version is available at https://doi.org/10.4103/joco.joco_67_24.

Copyright © 2025 Journal of Current Ophthalmology

Abstract

PURPOSE: To describe the demographic characteristics, etiology, microbiological spectrum, and antibiotic sensitivity patterns in patients with endophthalmitis.

METHODS: This is a retrospective case series spanning from May 2012 to September 2018. All included patients were diagnosed with endophthalmitis and confirmed by laboratory tests. Data were collected on patient demographics, types of endophthalmitis, and microbiologic and medical records.

RESULTS: Nine hundred ninety-two records of patients with endophthalmitis were assessed. Of the total cases, 657 patients (66.2%) were male, whereas 335 (33.8%) were female. The mean age of the patients was 57.2 ± 22.8 years and ranged from 2 to 95 years. The type of endophthalmitis was acute postcataract surgery (44.4%), posttraumatic (26.7%), chronic postcataract surgery (6.6%), endogenous (6.4%), postintravitreal injection (5.0%), keratitis-associated (3.6%), postvitrectomy (2.7%), bleb-associated (2.4%), postkeratoplasty (1.9%), and device-related (0.1%). The most frequently isolated organisms were Staphylococcus epidermidis (11.7%), followed by Streptococcus pneumoniae (5.2%) and Streptococcus viridans (5.1%). Antibiotic susceptibility testing in patients with acute postcataract surgery endophthalmitis showed variable sensitivity of S. epidermidis isolates to vancomycin (81.4%), ciprofloxacin (76.2%), and levofloxacin (75.0%). In patients with posttraumatic endophthalmitis, high rates of zone 1 injury (61.5%), traumatic cataract (67.9%), and intraocular foreign body (IOFB) (29.8%) were observed.

CONCLUSIONS: S. epidermidis is the most common causative pathogen in patients with endophthalmitis, its increasing resistance to vancomycin and fluoroquinolones may pose some challenges to the treatment of endophthalmitis in the future. Regarding the presence of IOFB, zone 1 injury, and traumatic cataracts that might be associated with an increased risk of posttraumatic endophthalmitis, it is better to consider these aspects in penetrating eye injuries.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

PubMed ID

40557410

Language

English

Download

Share

COinS