The Effect of Ametropia on Glaucomatous Visual Field Loss.

Authors

Eun Young Choi, Schepens Eye Research Institute of Massachusetts Eye and Ear; Harvard Medical School; Duke University Medical Center
Raymond C.S. Wong, Schepens Eye Research Institute of Massachusetts Eye and Ear; Harvard Medical School
Thuzar Thein, Schepens Eye Research Institute of Massachusetts Eye and Ear; Harvard Medical School
Louis R. Pasquale, Icahn School of Medicine at Mount Sinai
Lucy Q. Shen, Massachusetts Eye and Ear, Harvard Medical School
Mengyu Wang, Schepens Eye Research Institute of Massachusetts Eye and Ear; Harvard Medical School
Dian Li, Schepens Eye Research Institute of Massachusetts Eye and Ear; Harvard Medical School
Qingying Jin, Schepens Eye Research Institute of Massachusetts Eye and Ear; Jilin University
Hui Wang, Schepens Eye Research Institute of Massachusetts Eye and Ear; Jilin University of Finance and Economics
Neda Baniasadi, Schepens Eye Research Institute of Massachusetts Eye and Ear
Michael V. Boland, Johns Hopkins University
Siamak Yousefi, University of Tennessee Health Science Center
Sarah R. Wellik, University of Miami
Carlos G. De Moraes, Columbia University
Jonathan S. Myers, Wills Eye Hospital, Thomas Jefferson UniversityFollow
Peter J. Bex, Northeastern University,
Tobias Elze, Schepens Eye Research Institute of Massachusetts Eye and Ear; Harvard Medical School

Document Type

Article

Publication Date

6-25-2021

Comments

This article is the authors’ final published version in Journal of Clinical Medicine, Volume 10, Issue 13, June 2021, Article number 2796.

The published version is available at https://doi.org/10.3390/jcm10132796. Copyright © Choi et al.

Abstract

Myopia has been discussed as a risk factor for glaucoma. In this study, we characterized the relationship between ametropia and patterns of visual field (VF) loss in glaucoma. Reliable automated VFs (SITA Standard 24-2) of 120,019 eyes from 70,495 patients were selected from five academic institutions. The pattern deviation (PD) at each VF location was modeled by linear regression with ametropia (defined as spherical equivalent (SE) starting from extreme high myopia), mean deviation (MD), and their interaction (SE × MD) as regressors. Myopia was associated with decreased PD at the paracentral and temporal VF locations, whereas hyperopia was associated with decreased PD at the Bjerrum and nasal step locations. The severity of VF loss modulated the effect of ametropia: with decreasing MD and SE, paracentral/nasal step regions became more depressed and Bjerrum/temporal regions less depressed. Increasing degree of myopia was positively correlated with VF depression at four central points, and the correlation became stronger with increasing VF loss severity. With worsening VF loss, myopes have increased VF depressions at the paracentral and nasal step regions, while hyperopes have increased depressions at the Bjerrum and temporal locations. Clinicians should be aware of these effects of ametropia when interpreting VF loss.

Recommended Citation

Choi, Eun Young; Wong, Raymond C.S.; Thein, Thuzar; Pasquale, Louis R.; Shen, Lucy Q.; Wang, Mengyu; Li, Dian; Jin, Qingying; Wang, Hui; Baniasadi, Neda; Boland, Michael V.; Yousefi, Siamak; Wellik, Sarah R.; De Moraes, Carlos G.; Myers, Jonathan S.; Bex, Peter J.; and Elze, Tobias, "The Effect of Ametropia on Glaucomatous Visual Field Loss." (2021). Wills Eye Hospital Papers. Paper 139.
https://jdc.jefferson.edu/willsfp/139

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

34202033

Language

English