Document Type
Article
Publication Date
9-2021
Abstract
Purpose: To compare the outcomes of iStent vs. iStent inject implantation combined with phacoemulsification.
Methods: This single center retrospective comparative case series included subjects with open angle glaucoma who underwent iStent or iStent inject implantation combined with phacoemulsification with ≥1 year follow-up. The main outcome measures were in-group and between-group changes in intraocular pressure (IOP) and medication number, proportion of eyes that achieved IOP ≤15 mmHg, and surgical success defined as 20% IOP reduction from baseline at 6/12 months. Univariate/multivariate regression analyses were done to identify predictors of surgical failure.
Results: One hundred ninety-seven eyes of 148 patients were included (122 iStent, 75 iStent inject). Both groups achieved significant IOP and medication reduction at months 6/12 (P < 0.05). At month 6, IOP was significantly lower in iStent inject vs. iStent eyes (P = 0.003), but the difference was insignificant by month 12 (P = 0.172). Medication number was comparable in both groups at months 6/12 (P > 0.05). More iStent inject eyes achieved IOP ≤15 mmHg at month 6 (P = 0.003) and 12 (P = 0.047). Surgical success was comparable in both groups at months 6/12 (P > 0.05). Kaplan-Meier survival analysis showed similar cumulative rate of surgical failure at year-1 in both groups (P = 0.644). The multivariate model identified older age (P = 0.017) and lower baseline IOP (P = 0.002) as the strongest predictors of surgical failure.
Conclusion: Compared to iStent, iStent inject achieved lower IOP at month 6 and higher proportion of eyes achieved IOP ≤15 mmHg at month 6/12. However, surgical success was similar in both groups. Predictors of surgical failure were older age and lower baseline IOP rather than the stent type.
Recommended Citation
Shalaby, Wesam Shamseldin; Lam, Sophia S.; Arbabi, Amirmohsen; Myers, Jonathan S.; Moster, Marlene R.; Kolomeyer, Natasha N.; Razeghinejad, Reza; Shukla, Aakriti Garg; Hussein, Tarek R.; Eid, Tarek M.; Shalaby, Said M.; and Lee, Daniel, "iStent versus iStent inject implantation combined with phacoemulsification in open angle glaucoma." (2021). Wills Eye Hospital Papers. Paper 132.
https://jdc.jefferson.edu/willsfp/132
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.
PubMed ID
34427250
Language
English
Comments
This article is the authors’ final published version in Indian Journal of Ophthalmology, Volume 69, Issue 9, September 2021, Pages 2488-2495.
The published version is available at https://doi.org/10.4103/ijo.IJO_308_21. Copyright © Shalaby et al.