Amyloidosis of the urinary bladder is a rare cause of gross hematuria. In patients with systemic amyloidosis, identification is nearly always related to cardiac complaints; urologic presenting symptoms are extremely uncommon. We present a 77-year-old male patient with painless gross hematuria ultimately found to be secondary to systemic wild-type transthyretin amyloidosis. He underwent transurethral resection of the bladder lesion and was initiated on transthyretin stabilizing medication. In the 6 months since starting treatment, the patient has had no further episodes of gross hematuria, but will require cystoscopic surveillance for evidence of recurrence or concomittment urothelial carcinoma.
Recommended CitationVincent, Sage A.; Christensen, Daniel; and Weiner, Perry R., "Gross hematuria: An unusual presenting symptom of systemic wild-type transthyretinamyloidosis." (2021). Department of Urology Faculty Papers. Paper 65.
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