Metastatic Castrate-Resistant Prostate Cancer to the Penis Resulting in Malignant Priapism and Urethral Obstruction

Authors

Courtney Stewart, Thomas Jefferson University
Joon Yau Leong, Thomas Jefferson University
William Kevin Kelly, Thomas Jefferson UniversityFollow
Mihir Shah, Thomas Jefferson UniversityFollow

Document Type

Report

Publication Date

2-16-2026

Comments

This article is the author’s final published version in Urology Case Reports, Volume 65, 2026, Article number 103380.

The published version is available at https://doi.org/10.1016/j.eucr.2026.103380. Copyright © 2026 The Authors.

Abstract

A 76-year-old male with metastatic castrate-resistant prostate cancer was found to have metastatic disease to the urethra and penis on PSMA PET scan. This resulted in constant pain due to obstruction of blood flow through the corpora cavernosum resulting in priapism and urethral obstruction. The patient underwent a radical penectomy, partial urethrectomy and perineal urethrostomy creation. Final pathology confirmed metastatic prostatic adenocarcinoma. Although rare, prostate cancer can metastasize to the corpora spongiosum or cavernosa. Treatment options are limited, and surgical excision with urinary diversion is likely to provide the most durable outcomes for one's quality of life.

Recommended Citation

Stewart, Courtney; Leong, Joon Yau; Kelly, William Kevin; and Shah, Mihir, "Metastatic Castrate-Resistant Prostate Cancer to the Penis Resulting in Malignant Priapism and Urethral Obstruction" (2026). Department of Urology Faculty Papers. Paper 100.
https://jdc.jefferson.edu/urologyfp/100

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

PubMed ID

41737673

Language

English