Pyk2 Expression and Localization in Cardiac Mitochondria and Its Role in Mitochondrial Calcium Regulation

Authors

Ariele Baggett, Thomas Jefferson UniversityFollow
Celia Fernandez-Sanz, Thomas Jefferson UniversityFollow
Sergio De La Fuente, Thomas Jefferson UniversityFollow
Johannes Hoek, Thomas Jefferson University
Shey-Shing Sheu, Thomas Jefferson UniversityFollow

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Description

TRPM2 is a non-selective cation channel located in the plasma membrane of the cell. Upon activation, the channel opens, allowing calcium to enter into the cytosol of the cell, leading ultimately to the phosphorylation and activation of the enzyme Pyk2 (proline-rich tyrosine kinase 2). Once phosphorylated, Pyk2 translocates from the cytosol to the mitochondria, where it regulates the formation of the pore component of the mitochondrial calcium uniporter (MCU) complex. Consequently, this interaction is a key factor in mitochondrial calcium uptake and therefore mitochondrial bioenergetics.

Publication Date

9-27-2019

Keywords

mitochondria, Pyk2

Disciplines

Medicine and Health Sciences | Translational Medical Research

Comments

Presented at the 2019 National Heart, Lung, and Blood Institute Mitochondrial Biology Symposium

Recommended Citation

Baggett, Ariele; Fernandez-Sanz, Celia; De La Fuente, Sergio; Hoek, Johannes; and Sheu, Shey-Shing, "Pyk2 Expression and Localization in Cardiac Mitochondria and Its Role in Mitochondrial Calcium Regulation" (2019). Center for Translational Medicine Posters. 3.
https://jdc.jefferson.edu/transmedposters/3