A Single Institution Study of TERT Promoter Mutations Detected Upon Preoperative and Postoperative Testing of Thyroid Nodules: Characterization and Clinicopathologic Significance of TERT Mutations Occurring in Isolation and in Conjunction with Other Mutations or Gene Fusions

Authors

• Reem Khraishi, Thomas Jefferson University HospitalFollow
• Pradip Manna, Thomas Jefferson UniversityFollow
• Ujwala Gosavi, Thomas Jefferson UniversityFollow
• Phillip Palmer, Thomas Jefferson University HospitalFollow
• Andrew Neeson, Thomas Jefferson UniversityFollow
• Violet Quann, Thomas Jefferson University HospitalFollow
• Elizabeth Cottrill, Thomas Jefferson UniversityFollow
• Stacey Gargano, Thomas Jefferson UniversityFollow

Document Type

Poster

Publication Date

11-7-2026

Comments

Presented at the 2026 American Thyroid Association (ATA) Annual Meeting.

Abstract

Introduction

• Telomerase reverse transcriptase (TERT) promoter mutations occur in follicular cell-derived thyroid neoplasms, often coexisting with other mutations and associated with aggressive clinicopathologic features.
• The significance of TERT mutations occurring in isolation (iTERT) is unclear.
• We examined TERT-positive thyroid specimens (preoperative FNA and postoperative FFPE) to evaluate the clinicopathologic significance of this mutation occurring in isolation vs. in conjunction with other genetic alterations.

Recommended Citation

Khraishi, Reem; Manna, Pradip; Gosavi, Ujwala; Palmer, Phillip; Neeson, Andrew; Quann, Violet; Cottrill, Elizabeth; and Gargano, Stacey, "A Single Institution Study of TERT Promoter Mutations Detected Upon Preoperative and Postoperative Testing of Thyroid Nodules: Characterization and Clinicopathologic Significance of TERT Mutations Occurring in Isolation and in Conjunction with Other Mutations or Gene Fusions" (2026). Jefferson Hospital Staff Papers and Presentations. Paper 77.
https://jdc.jefferson.edu/tjuhpapers/77

Language

English