Document Type
Article
Publication Date
2-12-2025
Abstract
Objective
Female sex has been associated with improved survival after lung cancer resection. Our aim is to use a national database to describe sex disparities in early lung cancer treatment and evaluate whether outcomes of ethnic groups who traditionally have poorer outcomes are attenuated by female sex.Methods
This is a retrospective cohort study using the 2020 National Cancer Database. Adult patients diagnosed between 2010 and 2019 with early-stage non–small cell lung cancer (clinical T1 or T2, N0, M0) who received surgical resection with a known vital status were included. Patients who received neoadjuvant systemic or radiation therapy were excluded. Demographic data; clinicopathologic variables; 30-day, 90-day, 5-year mortality; and 5-year overall survival were analyzed.Results
We identified 192,927 patients with surgically resected early-stage non–small cell lung cancer. Mean patient age was 69 years (interquartile range, 62-75). Five-year overall survival among women was 72.8% versus 60.4% in men (P < .001), with the largest difference between Asian Pacific Islander women and men. Among women, White and Black women had the lowest 5-year overall survival. White and Black women had a higher 5-year overall survival than White, Black, Hispanic, and Other men.Conclusions
Female sex was associated with improved overall survival in patients with early-stage lung cancer regardless of ethnicity. However, there is significant variation between ethnic groups in the absolute size of this association. Additional studies are necessary to determine which factors contribute to this disparity, including but not limited to biological, clinical, and health-systems related.Recommended Citation
Rshaidat, Hamza; Madeka, Isheeta; Whitehorn, Gregory L.; Martin, Jonathan; Mack, Shale J.; Alaparthi, Sneha; Grenda, Tyler R.; Evans III, Nathaniel R.; and Okusanya, Olugbenga T., "Describing the Intersection of Ethnicity and Gender in Early-Stage Non-Small Cell Lung Cancer" (2025). Jefferson Hospital Staff Papers and Presentations. Paper 56.
https://jdc.jefferson.edu/tjuhpapers/56
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Language
English
Comments
This article is the author’s final published version in JTCVS Open, Volume 24, April 2025, Pages 438 - 450.
The published version is available at https://doi.org/10.1016/j.xjon.2024.12.015. Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery.