Document Type
Article
Publication Date
6-22-2024
Abstract
We describe a case of anaphylaxis during administration of intravenous (IV) ferumoxytol as a magnetic resonance imaging (MRI) contrast agent in a 4-year-old patient with complicated past medical history including YARS genetic mutation with resultant liver failure and deceased donor liver transplantation, stage IV chronic kidney disease (CKD), and hypertension. The patient was noted to have labored breathing 4 min after initiation of ferumoxytol infusion and was subsequently rapidly intubated and returned to the intensive care unit (ICU) for monitoring. Anaphylactic reactions to therapeutic doses of ferumoxytol led to issuance of a black box warning by the FDA in 2015. Adverse reactions to lower-dose ferumoxytol used in diagnostic imaging, however, are rare and there has been a paucity of documented anaphylactic reactions in the literature.
Recommended Citation
Ekladious, Fam and Saul, David, "A Case of Severe Anaphylactic Reaction After Administration of Diagnostic-Dose Ferumoxytol in a Pediatric Patient" (2024). Jefferson Hospital Staff Papers and Presentations. Paper 52.
https://jdc.jefferson.edu/tjuhpapers/52
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Language
English
Comments
This article is the author’s final published version in Case Report, Volume 54, June 2024, Pages 1553 – 1555.
The published version is available at https://doi.org/10.1007/s00247-024-05970-0. Copyright © The Author(s) 2024.
Publication made possible in part by support through a transformative agreement between Thomas Jefferson University and the publisher.