Elevated tRNA Halves in Olfactory Epithelial Cells of Patients With Schizophrenia

Authors

Justin T. Gumas, Thomas Jefferson UniversityFollow
Megumi Shigematsu, Thomas Jefferson UniversityFollow
Karin E. Borgmann-Winter, Thomas Jefferson UniversityFollow
C. G. Hahn, Thomas Jefferson UniversityFollow
Yohei Kirino, Thomas Jefferson UniversityFollow

Document Type

Letter to the Editor

Publication Date

1-16-2026

Comments

This article is the author’s final published version in The Journal of clinical investigation, Volume 136, Issue 2, 2026.

The published version is available at https://doi.org/10.1172/JCI195148. Copyright © 2026, Gumas et al.

Abstract

Schizophrenia patients' olfactory epithelial cells contain abundant immune-activating tRNA fragments, linking small RNA biology to inflammation and suggesting avenues for diagnostics.

Recommended Citation

Gumas, Justin T.; Shigematsu, Megumi; Borgmann-Winter, Karin E.; Hahn, C. G.; and Kirino, Yohei, "Elevated tRNA Halves in Olfactory Epithelial Cells of Patients With Schizophrenia" (2026). Computational Medicine Center Faculty Papers. Paper 65.
https://jdc.jefferson.edu/tjucompmedctrfp/65

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

41542771

Language

English