The Role of Non-Coding RNAs in Myelodysplastic Neoplasms

Authors

Vasileios Georgoulis
Epameinondas Koumpis
Eleftheria Hatzimichael, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

9-30-2023

Comments

This article is the author's final published version in Cancers, Volume 15, Issue 19, October 2023, Article number 4810.

The published version is available at https://doi.org/10.3390/cancers15194810. Copyright © 2023 by the authors.Licensee MDPI, Basel, Switzerland.

Abstract

Myelodysplastic syndromes or neoplasms (MDS) are a heterogeneous group of myeloid clonal disorders characterized by peripheral blood cytopenias, blood and marrow cell dysplasia, and increased risk of evolution to acute myeloid leukemia (AML). Non-coding RNAs, especially microRNAs and long non-coding RNAs, serve as regulators of normal and malignant hematopoiesis and have been implicated in carcinogenesis. This review presents a comprehensive summary of the biology and role of non-coding RNAs, including the less studied circRNA, siRNA, piRNA, and snoRNA as potential prognostic and/or predictive biomarkers or therapeutic targets in MDS.

Recommended Citation

Georgoulis, Vasileios; Koumpis, Epameinondas; and Hatzimichael, Eleftheria, "The Role of Non-Coding RNAs in Myelodysplastic Neoplasms" (2023). Computational Medicine Center Faculty Papers. Paper 49.
https://jdc.jefferson.edu/tjucompmedctrfp/49

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

37835504

Language

English