Document Type
Article
Publication Date
6-29-2023
Abstract
Recurrent epithelial erosions develop in the cornea due to prior injury or genetic predisposition. Studies of recurrent erosions in animal models allow us to gain insight into how erosions form and are resolved. While slowing corneal epithelial cell migration and reducing their proliferation following treatment with mitomycin C reduce erosion formation in mice after sterile debridement injury, additional factors have been identified related to cytokine expression and immune cell activation. The relationship between recruitment of immune cells to the region of the cornea where erosions form and their potential roles in erosion formation and/or erosion repair remains unexplored in the C57BL/6 mouse recurrent erosion model. Here, high resolution imaging of mouse corneas was performed at D1, D7, and D28 after dulled-blade debridement injury in C57BL/6 mice. Around 50% of these mice have frank corneal erosions at D28 after wounding. A detailed assessment of corneas revealed the involvement of M2 macrophages in both frank and developing erosions at early stages of their formation.
Recommended Citation
Le, Phuong M.; Pal-Ghosh, Sonali; Menko, A.; and Stepp, Mary Ann, "Immune Cells Localize to Sites of Corneal Erosions in C57BL/6 Mice." (2023). Computational Medicine Center Faculty Papers. Paper 45.
https://jdc.jefferson.edu/tjucompmedctrfp/45
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
37509096
Language
English
Comments
This article is the author's final published version in Biomolecules, Volume 13, Issue 7, 2023, Article number 1059.
The published version is available at https://doi.org/10.3390/biom13071059.
Copyright © 2023 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).