Document Type
Article
Publication Date
12-29-2020
Abstract
Aub guided by piRNAs ensures genome integrity by cleaving retrotransposons, and genome propagation by trapping mRNAs to form the germplasm that instructs germ cell formation. Arginines at the N-terminus of Aub (Aub-NTRs) interact with Tudor and other Tudor domain-containing proteins (TDRDs). Aub-TDRD interactions suppress active retrotransposons via piRNA amplification and form germplasm via generation of Aub-Tudor ribonucleoproteins. Here, we show that Aub-NTRs are dispensable for primary piRNA biogenesis but essential for piRNA amplification and that their symmetric dimethylation is required for germplasm formation and germ cell specification but largely redundant for piRNA amplification.
Recommended Citation
Vrettos, Nicholas; Maragkakis, Manolis; Alexiou, Panagiotis; Sgourdou, Paraskevi; Ibrahim, Fadia; Palmieri, Daniel; Kirino, PhD, Yohei; and Mourelatos, Zissimos, "Modulation of Aub-TDRD interactions elucidates piRNA amplification and germplasm formation." (2020). Computational Medicine Center Faculty Papers. Paper 31.
https://jdc.jefferson.edu/tjucompmedctrfp/31
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
33376130
Language
English
Comments
This article is the author’s final published version in Life Science Alliance, Volume 4, Issue 3, December 2020, Article number e202000912.
The published version is available at https://doi.org/10.26508/LSA.202000912. Copyright © Vrettos et al.