Extrahepatic Cholangiocarcinoma: Genomic Variables Associated with Anatomical Location and Outcome

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Document Type

Presentation

Presentation Date

6-20-2024

Comments

2nd Place Award

Presentation: 11:21

Abstract

Background

- Cholangiocarcinoma: rare & heterogenous group of cancers characterized by poor prognosis

- Genomic underpinnings of intrahepatic cholangiocarcinoma well described

  • No individual alteration accounting for more than ~40% of cases
  • Poor Prognosis: TP53, KRAS, & CDKN2A
  • Therapeutic Targets: FGFR2, IDH1, BRAF, HER2, etc.

- They remain less clear for extrahepatic cholangiocarcinoma (ECA)

  • Difference between subtypes: distal (DCA) & perihilar (PCA)
  • Relationship between DCA & pancreatic cancer (characterized by high rate of KRAS alterations)
  • Prognostic implications

Language

English

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