Document Type
Article
Publication Date
2-28-2024
Abstract
BACKGROUND: Surgeons rarely perform elective total pancreatectomy (TP). Our study seeks to report surgical outcomes in a contemporary series of single-stage (SS) TP patients.
METHODS: Between the years 2013 to 2023 we conducted a retrospective review of 60 consecutive patients who underwent SSTP. Demographics, pathology, treatment-related variables, and survival were recorded and analyzed.
RESULTS: SSTP consisted of 3% (60/1859) of elective pancreas resections conducted. Patient median age was 68 years. Ninety percent of these patients (n = 54) underwent SSTP for pancreatic ductal adenocarcinoma (PDAC). Conversion from a planned partial pancreatectomy to TP occurred intraoperatively in 31 (52%) patients. Fifty-nine patients (98%) underwent an R0 resection. Median length of hospital stay was 6 days. The majority of morbidities were minor, with 27% patients (n = 16) developing severe complications (Clavien-Dindo ≥3). Thirty and ninety-day mortality rates were 1.67% (one patient) and 5% (three patients), respectively. Median survival for the entire cohort was 24.4 months; 22.7 months for PDAC patients, with 1-, 3-, and 5-year survival of 68%, 43%, and 16%, respectively. No mortality occurred in non-PDAC patients (n = 6).
CONCLUSION: Elective single-stage total pancreatectomy can be a safe and appropriate treatment option. SSTP should be in the armamentarium of surgeons performing pancreatic resection.
Recommended Citation
Zohar, Nitzan; Kowal, Luke; Moskal, David; Ponzini, Francesca; Sun, George; Lamm, Ryan J.; Williamson, John; Nevler, Avinoam; Lavu, Harish; Maley, Warren R.; Yeo, Charles J.; and Bowne, Wilbur B., "Contemporary Report of Surgical Outcomes After Single-stage Total Pancreatectomy: A 10-year Experience" (2024). Department of Surgery Faculty Papers. Paper 307.
https://jdc.jefferson.edu/surgeryfp/307
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
38419193
Language
English
Comments
This article is the author’s final published version in the Journal of Surgical Oncology, Volume 129, Issue 7, June 2024, Pages 1235-1244.
The published version is available at https://doi.org/10.1002/jso.27614. Copyright © 2024 The Authors. Journal of Surgical Oncology published by Wiley Periodicals LLC.
Publication made possible in part by support through a transformative agreement between Thomas Jefferson University and the publisher.