Real-World Maintenance Therapy and Survival Outcomes for Pembrolizumab Plus Pemetrexed and Platinum for Non-Small-Cell Lung Cancer in USA
Aim: To evaluate treatment patterns and overall survival (OS) in real world metastatic non-squamous non-small-cell lung cancer (NSQ-NSCLC) patients that received pembrolizumab plus pemetrexed-platinum (pembro+pem+plat) aligned with KEYNOTE-189.
Materials & methods: OS was evaluated for the overall cohort and maintenance therapy (MT) subgroups and analyzed using Kaplan-Meier estimates and Cox proportional hazards model.
Results: Of 2488 patients that received first-line treatment, 45.1% received less than four cycles of pembro+pem+plat, 43.9% received four cycles plus MT with pembro and/or pem, and 11.1% received four cycles without continuing on MT. The median OS was 21.0 months and 9.1 months in patients that continued and did not continue MT.
Conclusion: Real world patients that received KEYNOTE-189-aligned treatment had similar OS benefits.
Aggarwal, Himani; Bayo, KayOnda; Han, Yimei; Muehlenbein, Catherine Elizabeth; Zhu, Yajun Emily; and Kim, Jong Seok, "Real-World Maintenance Therapy and Survival Outcomes for Pembrolizumab Plus Pemetrexed and Platinum for Non-Small-Cell Lung Cancer in USA" (2023). Student Papers & Posters. Paper 95.
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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
This article is the author's final published version in Immunotherapy, Volume 15, Issue 4, Volume 4, 2023, Pg. 267 - 281.
The published version is available at https://doi.org/10.2217/imt-2022-0166. For full bibliographic citation, please refer to the version available at www.futuremedicine.com. Copyright © 2023 Eli Lilly and company.