Lower Versus Higher Oxygen Targets for Out-Of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis

Authors

Xin Cheng
Yu Zhang
Haidong Deng
Yuning Feng
Weelic Chong, Thomas Jefferson UniversityFollow
Yang Hai, Thomas Jefferson UniversityFollow
Pengfei Hao
Jialing He
Tiangui Li
Liyuan Peng
Peng Wang
Yangchun Xiao
Fang Fang

Document Type

Article

Publication Date

10-19-2023

Comments

This article is the author's final published version in Critical Care, Volume 27, 2023, Article number 401.

The published version is available at https://doi.org/10.1186/s13054-023-04684-3. Copyright © The Author(s) 2023.

Abstract

BACKGROUND: Supplemental oxygen is commonly administered to patients after out-of-hospital cardiac arrest. However, the findings from studies on oxygen targeting for out-of-hospital cardiac arrest are inconclusive. Thus, we conducted a systematic review and meta-analysis to evaluate the impact of lower oxygen target compared with higher oxygen target on patients after out-of-hospital cardiac arrest.

METHODS: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, from inception to February 6, 2023, for randomized controlled trials comparing lower and higher oxygen target in adults (aged ≥ 18 years) after out-of-hospital cardiac arrest. We screened studies and extracted data independently. The primary outcome was mortality at 90 days after cardiac arrest. We assessed quality of evidence using the grading of recommendations assessment, development, and evaluation approach. This study was registered with PROSPERO, number CRD42023409368.

RESULTS: The analysis included 7 randomized controlled trials with a total of 1451 participants. Compared with lower oxygen target, the use of a higher oxygen target was not associated with a higher mortality rate (relative risk 0.97, 95% confidence intervals 0.82 to 1.14; I

CONCLUSION: Lower oxygen target did not reduce the mortality compared with higher oxygen target in patients after out-of-hospital cardiac arrest.

Recommended Citation

Cheng, Xin; Zhang, Yu; Deng, Haidong; Feng, Yuning; Chong, Weelic; Hai, Yang; Hao, Pengfei; He, Jialing; Li, Tiangui; Peng, Liyuan; Wang, Peng; Xiao, Yangchun; and Fang, Fang, "Lower Versus Higher Oxygen Targets for Out-Of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis" (2023). Student Papers, Posters & Projects. Paper 130.
https://jdc.jefferson.edu/student_papers/130

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

Language

English