Advancements in Dendritic Cell Vaccination: Enhancing Efficacy and Optimizing Combinatorial Strategies for the Treatment of Glioblastoma

Authors

Robert Subtirelu
Eric Teichner, Thomas Jefferson UniversityFollow
Arjun Ashok, Thomas Jefferson UniversityFollow
Chitra Parikh, Thomas Jefferson UniversityFollow
Sahithi Talasila, Thomas Jefferson UniversityFollow
Irina-Mihaela Matache
Ahab Alnemri
Victoria Anderson, Thomas Jefferson UniversityFollow
Osmaan Shahid
Sricharvi Mannam
Andrew Lee
Thomas Werner
Mona-Elisabeth Revheim
Abass Alavi

Document Type

Article

Publication Date

10-31-2023

Comments

This article, first published by Frontiers Media, is the author's final published version in Frontiers in Neurology, Volume 14, 2023, Article number 1271822.

The published version is available at https://doi.org/10.3389/fneur.2023.1271822.

Copyright © 2023 Subtirelu, Teichner, Ashok, Parikh, Talasila, Matache, Alnemri, Anderson, Shahid, Mannam, Lee, Werner, Revheim and Alavi.

Abstract

Glioblastomas (GBM) are highly invasive, malignant primary brain tumors. The overall prognosis is poor, and management of GBMs remains a formidable challenge, necessitating novel therapeutic strategies such as dendritic cell vaccinations (DCVs). While many early clinical trials demonstrate an induction of an antitumoral immune response, outcomes are mixed and dependent on numerous factors that vary between trials. Optimization of DCVs is essential; the selection of GBM-specific antigens and the utilization of ¹⁸F-fludeoxyglucose Positron Emission Tomography (FDG-PET) may add significant value and ultimately improve outcomes for patients undergoing treatment for glioblastoma. This review provides an overview of the mechanism of DCV, assesses previous clinical trials, and discusses future strategies for the integration of DCV into glioblastoma treatment protocols. To conclude, the review discusses challenges associated with the use of DCVs and highlights the potential of integrating DCV with standard therapies.

Recommended Citation

Subtirelu, Robert; Teichner, Eric; Ashok, Arjun; Parikh, Chitra; Talasila, Sahithi; Matache, Irina-Mihaela; Alnemri, Ahab; Anderson, Victoria; Shahid, Osmaan; Mannam, Sricharvi; Lee, Andrew; Werner, Thomas; Revheim, Mona-Elisabeth; and Alavi, Abass, "Advancements in Dendritic Cell Vaccination: Enhancing Efficacy and Optimizing Combinatorial Strategies for the Treatment of Glioblastoma" (2023). Student Papers, Posters & Projects. Paper 122.
https://jdc.jefferson.edu/student_papers/122

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

Language

English