Document Type

Abstract

Publication Date

2-11-2026

Academic Year

2025-2026

Comments

Presented at the 2026 Scholarly Inquiry (SI) Research Project Symposium.

Abstract

Introduction: Epilepsy is a major neurological disorder affecting approximately 1% of adults in the United States. Among the nearly one-third of patients with drug-resistant epilepsy, resective surgery guided by prior stereotactic electroencephalography (SEEG) can be curative. However, the optimal interval between the procedures remains poorly defined. Prolonged intervals may allow for evolution of the epileptogenic network, potentially affecting surgical outcomes. This study evaluated seizure outcomes in patients undergoing both SEEG and subsequent resective surgery.

Methods: In this retrospective, single-institution study, electronic medical records of 29 patients who underwent SEEG followed by resective surgery were reviewed. Patients were divided into early versus late intervention groups based on the median interval between SEEG and resection. Seizure outcomes were categorized as complete versus incomplete seizure freedom at follow-up. Outcomes were compared by Chi-square analysis. No perioperative complications were noted.

Results: The median interval from SEEG to resection was 11 weeks. Two patients had intervals greater than one year. Median postoperative follow-up from resection was 17 weeks, and 19 patients achieved complete seizure freedom. Chi-square analysis did not identify a significant association between interval length and seizure outcome (χ² = 0.2764, p = 0.5991).

Conclusions: In this cohort, the interval between SEEG and resection was not significantly associated with postoperative seizure freedom. These findings suggest that modest delays between the procedures may not adversely affect short-term seizure outcomes. However, given the small sample size and limited follow-up, larger studies with long-term follow-up are needed to determine whether surgical timing meaningfully affects postoperative seizure outcomes.

Additional Files
Ratan_Sanyam_poster.pdf (1440 kB)

Language

English

Download

Share

COinS