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Introduction: The lack of effective treatments for Alzheimer’s Disease (AD) underscores the importance of prevention and early detection of amnestic mild cognitive impairment (aMCI), its prodromal state. While studies have proposed a number of potential mechanisms underlying the pathogenesis of AD, such as hypoxia and neuropsychiatric symptoms, little research has been done to evaluate predictive risk factors.

Objective: The objective of this pilot study is to assess the prevalence and risk factors for aMCI.

Methods: This cross-sectional study was performed using data from patients screened for Memories 2, a clinical trial evaluating the effect of CPAP usage in patients with both obstructive sleep apnea and aMCI. The study included patients recruited from the Jefferson Sleep Center between the ages of 55 and 85. Subjects were divided into two groups based on their score in the Modified Telephone Interview for Cognitive Status (m-TICS): (a) positive screen (+) for aMCI (m-TICS score = 28-35), and (b) negative screen (-) for aMCI (m-TICS score < 28). Risk factors were assessed using multivariate analysis.

Results: The prevalence of + aMCI among patients in a primary care setting was X% (n=total). + aMCI was more likely to be associated with increased age (p = ) and multiple comorbidities (p= ). Specifically, patients with aMCI were more likely to have cardiovascular disease and current depressive symptoms.

Discussion: The preliminary results of this pilot study suggest a potential role for aMCI risk factor profiling in patients with OSA. A larger study is needed to adequately compare the predictive value of specific risk factors for aMCI.