Atrial fibrillation is one of the leading causes of heart failure and stroke in the US, meaning that optimizing treatment is essential. There are two catheter based PVI techniques used to treat drug-refractory AF patients: radiofrequency and cryo-balloon ablation. The goal of this study is to determine if there is a difference in efficacy between these two procedures.
The study consisted of a retrospective chart review and ECG analysis of approximately 130 patients. The criteria for involvement is patients diagnosed with drug-refractory paroxysmal AF and who have undergone an ablation procedure in the past two years. Baseline characteristics were measured from EPIC and p-wave parameters were measured on ECG’s using MUSE. Statistical analysis was done to determine if there is any significant difference in p wave parameters between the two groups of patients.
At this point in time, there remains data to be collected, but we are able to share preliminary results. The only significant finding was when we looked at p-wave duration, specifically the change in V1 duration, which showed that patients were less likely to have an AF recurrence if their p-wave duration lengthened after the procedure.
These results are important, as the change of lead V1 duration could be used as a predictor of AF recurrence. However, at this point we are unable to find a difference in efficacy between cryo-ablation and RF ablation and so our main objective is incomplete. the hope is upon completing data collection, we will be able to answer our research question.
Khan, Waleed; Pavri, Behzad; and Schanz, John, "Cryo vs RF p-wave Characteristics Comparative Analysis" (2021). Phase 1. Paper 4.